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Biomedical subjects

A I Lobakov

Publications and source records attributed to A I Lobakov.

41 records · Page 3Linked to original sources
PubMedDate not supplied

[Choice of a method of extracorporeal detoxication in pyogenic peritonitis].

An experience of using discrete exchange plasmapheresis (DEP), filtration exchange plasmapheresis (FEP), hemofiltration (HF) and plasmafiltration (PF) in combination with ultraviolet (UV) irradiation of autoblood has been reviewed in 92 patients with pyogenic peritonitis. It has been shown that HF (PF) is an effective and pathogenetically grounded method of detoxication in patients with disseminated pyogenic peritonitis at a stage of polyorgan failure. FEP must be a method of choice during complex therapy at terminal phases of disseminated pyogenic peritonitis. The mechanisms of FEP therapeutic effect are based on elimination of a wide range of toxic substances, correction of severe metabolic disturbances, improvement of central and liver hemodynamics and, in combination with UV irradiation of autoblood, on bacteriocide and antihypoxic effect. The use of DEP is restricted to local pyogenic processes in the abdominal cavity.

Adolescent↗
PubMedDate not supplied

[The use of a generalized biochemical parameter for the evaluation of the effectiveness of hemosorption in patients with mechanical jaundice of calculous etiology].

Quantitative methods for evaluation of impairments in the functional state of liver tissue by means of a generalized biochemical index enabled to evaluate efficiency of hemosorption as compared with other methods of preoperative treatment of patients with mechanical jaundice of calculous genesis. Hemosorption was found to contribute most effectively to restoration of the liver tissue functional state decreasing the risk of acute liver tissue insufficiency during the postoperational period.

Bilirubin↗
PubMedDate not supplied

[Slow-flow membrane oxygenation of blood as a method of detoxication in the treatment of patients with abdominal sepsis].

The criteria of efficacy of small-flow membranous oxygenation of the blood were defined and the duration of this measure optimized in the treatment of 30 patients hospitalized at the department for abdominal surgery, Moscow District Research and Clinical Institute, after operations for abdominal diseases and purulent complications thereof performed at hospitals of the Moscow district. Small-flow membranous oxygenation of the blood brought about a trend to normalization of the peripheral blood parameters which were changed as a result of inflammation; it was conducive to normalization of the blood acid-base status and oxygen extraction by tissues, and had an immunostimulating effect in general. The level of medium-weight molecular peptides may be regarded as a criterion of the efficacy of small-flow membranous oxygenation of the blood. With an initial concentration of medium-weight molecules of at least 1 arbitrary unit, the procedure may be as short as just two hours. Under such conditions, small-flow membranous oxygenation of the blood may be considered as a specific detoxifying method.

Abdomen↗
PubMedDate not supplied

[Low-flow membrane oxygenation of blood in patients with diffuse purulent peritonitis].

Small-flow membranous oxygenation of the blood was used in 45 patients with peritonitis in the multiple organ failure phase. In ten cases blood oxygenation was combined with hemofiltration. MOCT 19-03 (Kvant Research and Production Unit) and Gambro FH hemofilters (Sweden) were employed. Combination of small-flow membranous oxygenation of the blood combined with hemofiltration appreciably improved the oxygen-transporting function of the blood in adult patients with the respiratory distress syndrome, which was due to mutual potentiation of the two methods' effects. Small-flow membraneous oxygenation alone improved cellular immunity and decreased the laboratory manifestations of endogenous intoxication due to biotransformation of toxic products.

Adolescent↗