[Bronchological study, laparoscopy and laparatomy in the more precise diagnosis of lung cancer].
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Biomedical subjects
Publications and source records attributed to A I Pirogov.
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Transthoracic aspiration needle biopsy is the principal technic of obtaining the material for morphological verification of the diagnosis in apical lung cancer with the Pancoast syndrome in particular. Since transthoracic aspiration biopsy is feasible and readily available, it may be used successfully not only clinically but also in outpatient conditions.
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110 lung cancer patients over 70 were examined. 56 patients mainly with peripheral cancer of stage II-III have been operated upon in satisfactory functioning of the respiratory and cardiovascular systems. The operability was 50.9%, respectability--91%. Partial pneumonectomies were performed in 80.3%, these comprised both lobectomy and segmental or wedge resections. The postoperative complications were noted in 37.5%, mainly as arrhythmia, atelectasis, pneumonia. The postoperative mortality was 7.1%.
Extensive metastatic proliferation is rather characteristic of cancer of the lower esophagus. In persons who died due to progression of the disease metastases are revealed in 3 of 4 cases, lymphogenic metastases prevailing over hematogenic ones in the ratio of 3 : 2. Clinical investigations indicate early metastases in cancer of the lower esophagus, intraoperatively these are detected in a half of all the cases, in radical surgery--in 41.3%, in tentative surgery--in 72.8%. Unresectable metastases as frequently as tumor invasion of the adjacent organs are the cause why the radical operation was refused (1 : 1). Intraoperative diagnosis of metastatic dissemination of cancer of the lower esophagus is far from being perfect, which is evidenced by not infrequent detection at autopsy of unremoved metastases in persons, died within the terms up to 3 months following radical surgery (16.8%). Among persons, died after the resection of distal esophageal segments with the construction of esophagastroanastomosis, metastases in the pleural cavity are detected in every fifth person (21.7%), among those died following the Torek surgery--twice as frequent. Among patients who died during the period of 3 months after radiation therapy for cancer of the lower esophagus metastases in lymph nodes and abdominal organs, i.e. beyond the zone of radiation effect, were found in a half of cases.
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Not infrequently cancer of the middle and lower thirds of the esophagus metastasizes into the subfrenic lymph nodes, which justifies a revisional laparotomy for completing the diagnosis of the tumor process spreading. A peduncular gastrostomy is carried out at the revisional laparotomy. A one-stage operation of extirpation and plasty of the esophagus with a stomach tube, housed in the bed of ablated esophagus, involves a great risk and is followed by a high fatality rate.
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The peculiarities of clinical manifestations of glandular carcinoma of the lung have been studied, an account is taken of histological tumor variants and the degree of tumor proliferation. The results of treatment are analysed in relation to the prognosis of the disease in 305 patients. The peculiar clinical course of lung adenocarcinoma seems to be due to the predominantly peripheral kind of the tumor and relatively prompt lympho-hematogenic metastasization. Marked anaplasia of the tumor revealed morphologically is usually indicative of the dissemination even in insignificant local spread. Satisfactory results of surgical treatment are gained only in early stages (I--II), mainly in patients with high-differentiated adenocarcinoma.
More than 20 years' experience with surgical exploration in cancer of the lung is generalized in this article. The use of prescalene biopsy allowed to find out metastases in 130 out of 308 patients (42.2%), mediastinoscopy helped to refine the degree of the propagation of the process in 36.2%, and parasternal mediastinotomy--in 49.5%. Due to laparoscopy and laparotomy metastases in the abdominal organs (liver, adrenal glands, retroperitoneal nodes) were found in 22 out of 162 patients. The diagnostic thoracotomy carried out upon 109 patients revealed tumors of the lungs in 50 patients, in 47 out of them it was an early stage of primary cancer.
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