Proceedings: 243. Effects on Ca2+-binding of isolated synaptosomes of Mg2+ and La3+.
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Animals↗
Biomedical subjects
A Inoue
Publications and source records attributed to A Inoue.
[Proceedings: 296. Patterns of regional differentiation of sympathetic efferents induced by various stimulation (author's transl)].
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Animals↗
[A new pathophysiological explanation of ciguaterra (author's transl)].
After pointing out clinical, biochemical and biological similarities between paralytic shellfish poisoning and ciguaterra fish poisoning, the authors describe their recent discoveries in regard to ciguaterra origin. The causal agent searched without results since many years, might be a dinoflagellate, of the genus Diplopsalis.
Ciguatera Poisoning↗
Vasoformative tumor of the brain--immunohistology and ultrastructure.
A congenital vasoformative tumor in the brain of a 2-week-old boy manifested a variety of vascular spaces ranging from varices to solid cellular areas. The location of rod-shaped forms of reactivity to the immunoperoxidase stain for Factor VIII-related antigen corresponded with that of numerous Weibel-Palade bodies in the endothelial cell component of the tumor.
Antigens↗
Aggressive bone tumorous lesion in infancy: osteofibrous dysplasia of the tibia and fibula.
The clinical experiences of 10 patients with osteofibrous dysplasia were reviewed. Mean age of the patients was 7.3 years; all had an intracortical, eccentric lesion in the anterior aspect of the shaft of the tibia. Seven of the patients underwent either an excision or an en bloc resection; the lesion recurred in four of the seven, and one showed pseudarthrosis. Surgical outcomes were unsatisfactory, especially in the younger patients. In contrast, the remaining three patients who did not undergo surgery showed satisfactory results. Nonsurgical treatment is generally recommended except in cases in which impending deformities seem certain. Osteofibrous dysplasia was characterized histologically by osteoid rimmed by osteoblasts, sinusoid surrounding osteoid, many osteoclasts in the sinusoid, and fibrous stroma. Ultrastructurally, stroma cells revealed the characteristics of preosteoblasts. Osteogenic potentiality was well-documented. This tumorous condition is likely attributed to dysremodelling, in which osteoclastosis is dominant to osteogenesis. Abnormal blood circulation in the periosteum is the likely pathogenesis of osteofibrous dysplasia.
Adolescent↗
Chylopericardium following right thoracotomy for lung cancer.
A 69-year-old woman underwent the right upper lobectomy, a partial resection of right segment 6 (rt S6) and removal of mediastinal lymph nodes (LN) for adenocarcinoma of the lung (rt S2), stage IIIA (T2N2M0). A chest computerized tomography (CT) taken one month after the operation revealed a pericardial effusion which was milky in color, and contained high levels of triglycerides (TG) of 615 mg/dl (serum, 217 mg/dl). Cytology of effusion for malignant cells was negative. The pericardial effusion gradually decreased in one month by restriction of her fat intake. Chylopericardium following right thoracotomy for lung cancer is extremely rare.
Adenocarcinoma↗
Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptor subtypes.
We analyzed the displacement activity of sarpogrelate and its active metabolite (M-1) in the radiolabeled ligand binding to various 5-hydroxytryptamine (5-HT) receptor subtypes using rat brain cortical membranes. Sarpogrelate was shown to have the same affinity as ritanserin for 5-HT2A receptors, with a Ki value of 8.39 nM. The active metabolite of sarpogrelate, M-1, was more active than sarpogrelate itself and of ritanserin, with a Ki value of 1.70 nM. Both sarpogrelate and M-1 had no affinity for 5-HT1A receptors, but these substances, at a concentration of 10 microM, displaced the specific binding to the 5-HT1B receptors of [125I]iodocyanopindolol, resulting in Ki values of 0.881 and 0.859 microM, respectively. The Ki values of sarpogrelate and M-1 are almost the same as that of ritanserin, a specific 5-HT2 receptor antagonist. Sarpogrelate and M-1, as well as ritanserin, are shown to have very low affinity for 5-HT1B receptors. Both sarpogrelate and M-1 had no affinity for 5-HT3 receptor subtypes. In the 5-HT4 receptor binding experiments, sarpogrelate exhibited almost no affinity, while M-1, at the concentration of 10 microM, displaced the binding activity, resulting in a Ki value of 0.838 microM. Both drugs had a weak antagonistic effect on a 5-HT4 receptor-mediated function, i.e., the 5-HT-induced relaxation of rat isolated esophageal tunica muscularis mucosae. In conclusion, sarpogrelate and M-1 have high affinity for 5-HT2A receptors with a relatively high selectivity.
8-Hydroxy-2-(di-n-propylamino)tetralin↗