Identification of a frameshift mutation (557 del T) in exon 4 of the CFTR gene.
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Base Sequence↗
Biomedical subjects
A J Hill
Publications and source records attributed to A J Hill.
Across-the-day monitoring of mood and energy intake before, during, and after a very-low-calorie diet.
Mood, hunger, and energy intake were monitored in eight obese women before, during, and after 2 wk on a very-low-calorie diet (VLCD). Energy intake was significantly lower by approximately 30% in the week after the VLCD compared with the prediet week, both from food diaries and at a controlled ad libitum test meal. There was a gradual reduction in hunger, irritability, and urge to eat after 1 wk on the VLCD, which persisted through the postdiet week. Hunger and discontent were greatest in the evening during the first few days of the VLCD but diminished as the duration of the VLCD increased.
Affect↗
Eating in the adult world: the rise of dieting in childhood and adolescence.
Dieting is a common practice among adolescent girls. Recent research suggests that adolescent dieting may not be benign and that it is becoming more frequent in younger age groups. The present study investigated dieting motivation and the underlying attitudes to body weight and shape in two age groups. Eighty-four nine-year-old and 86 14-year-old girls from the same school completed assessments of dietary restraint, body esteem, body satisfaction and body figure preferences. The girls' body weight and height were also measured. The distribution of restraint scores revealed individuals from both age groups in every category of dieting motivation. Subjects in the upper and lower quartiles of the restraint distribution were identified and compared on the other measures. The highly restrained girls expressed low body esteem and discontent with their body build, weight and certain regions of their bodies. Furthermore, their 'ideal' body shape was significantly slimmer than their perceived current body shape, and slimmer even than that of the non-dieters. This pattern held for both the nine- and 14-year-olds, of whom half of each age group were of average or below average weight index for their age. The appearance of these dispositions and behaviours by the age of nine, or possibly earlier, may result in a marked increase in future clinical eating problems and disorders.
Adolescent↗
Dexfenfluramine and appetite in humans.
Dexfenfluramine has been demonstrated to produce decreases in daily energy intake varying between 13 and 25% depending on the time for which the drug has been administered. This reduction in energy intake is achieved by a decrease in the size of meals (11-40% depending on the dose) and by a decrease in the frequency of snacks consumed between meals. These objective adjustments are accompanied by a decrease in the level of perceived hunger, particularly apparent in the postprandial period. Taken together these changes can be interpreted as an action of dexfenfluramine to intensify the satiating power of food. This effect is consistent with the proposed role of serotonin systems in the mediation of satiety. The effect of dexfenfluramine on eating parameters leads to an overall modulation of the pattern of eating and the profile of motivation to eat. The reduction in energy intake achieved by this modulation is consistent with the weight losses recorded following several months of treatment. This restraint over the expression of appetite exerted by dexfenfluramine appears to be present even after 12 months of continuous treatment. These demonstrated actions should help overweight people to achieve a better management of their appetite in order to assist weight loss and to prevent weight regain.
Appetite↗
Overview of the effects of intravenous milrinone in acute heart failure following surgery.
We have reviewed the current data evaluating the effects of intravenous milrinone in patients following cardiac surgery. Milrinone has been shown to be effective in the treatment of acute low output syndrome, and a loading bolus infusion of 50 micrograms kg-1 over 10 min causes an increase in cardiac index and a fall in pulmonary capillary wedge pressure. These effects are easily maintained by a continuous infusion regimen. Other haemodynamic effects are seen, including systemic and pulmonary vasodilatation and an increase in heart rate. These effects are not confined to one patient group, but the increase in cardiac index does appear to be more pronounced in those patients with poor haemodynamics prior to treatment. There is a low incidence of adverse events including arrhythmias and hypotension. Thus milrinone appears to be well tolerated in a broad group of adult patients recovering from cardiac surgery.
Cardiac Output↗
Food craving, dietary restraint and mood.
A common assumption is that dieting causes food cravings, probably as a result of food energy deprivation. This issue was investigated in a two-phase study. In phase one, 206 women completed the Dutch Eating Behaviour Questionnaire, the Three-Factor Eating Questionnaire and a food craving scale. A correlational analysis showed food craving to be only weakly related to dietary restraint, but highly and significantly correlated with external eating, emotional eating and susceptibility to hunger. In phase two, ten women who regularly experienced food cravings and ten who rarely craved food kept prospective records of their food intake, daily mood and food craving episodes. There were few differences in eating behaviour, although the cravers tended to consume slightly more daily energy than the non-cravers. The cravers had higher ratings of boredom and anxiety during the day, and dysphoric mood was prominent prior to the cravings themselves. Food deprivation does not appear to be a necessary condition for food cravings to occur. Rather, food cravings are closely associated with mood, in particular as an antecedent to craving and also as a consequence of craving.
Adult↗
The haemodynamic effects of bronchoscopy. Comparison of propofol and thiopentone with and without alfentanil pretreatment.
The haemodynamic response to bronchoscopy under general anaesthesia was investigated. Forty patients were allocated at random to receive either thiopentone or propofol; half the patients in each group received in addition 18 micrograms/kg of alfentanil one minute before induction of anaesthesia. The heart rate, noninvasive blood pressure and Holter ECG was monitored in all patients. Significant increases in heart rate (p less than 0.05), systolic and diastolic arterial pressures (p less than 0.01) occurred in the thiopentone only group, following bronchoscopy. Systolic and diastolic arterial pressure decreased in patients receiving thiopentone plus alfentanil, following induction of anaesthesia and laryngoscopy (p less than 0.05). No significant haemodynamic changes were seen in either of the groups which received propofol. ST segment changes on subsequent Holter analysis were seen in four patients, but there were no significant differences between the groups. Anaesthesia with propofol alone provides adequate haemodynamic stability for bronchoscopy and the addition is superfluous.
Aged↗
Dieting concerns have a functional effect on the behaviour of nine-year-old girls.
The eating patterns of restrained and unrestrained nine-year-old girls were compared. Prospective seven-day food diary records showed the restrained girls to eat significantly less energy and dietary fibre than the unrestrained. Their ratings of hunger were also significantly higher. Most nutritional indicators, however, showed their diet to be of adequate quality. The translation of dieting concerns into dieting behaviour by nine-year-olds may increase their susceptibility to future clinical eating problems.
Child↗
A surgical technique for the treatment of advanced derangement of the temporomandibular joint.
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Humans↗
Oral administration of proteinase inhibitor II from potatoes reduces energy intake in man.
The effect of a proteinase inhibitor extracted from potatoes (POT II) which increases CCK release, on food intake was examined in 11 lean subjects. They received 1.5 g POT II in a high-protein soup vehicle (70 kcal), the soup vehicle alone, or a no-soup control five minutes before being presented with a lunchtime test meal, according to a double-blind, within-subjects design. Consuming the soup alone led to a nonsignificant 3% reduction in energy intake. The addition of 1.5 g POT II to the soup significantly reduced energy intake by a further 17.5%. Premeal ratings of motivation to eat and food preferences did not predict the reduction in energy intake by the proteinase inhibitor. These findings suggest that endogenous CCK may be important in the control of food intake and that proteinase inhibition may have therapeutic potential for reducing food intake.
Adult↗
Developing concerns with dietary restraint: a supplement to Tuschl.
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Adolescent↗
Carboxyhaemoglobin concentrations, pulse oximetry and arterial blood-gas tensions during jet ventilation for Nd-YAG laser bronchoscopy.
Oxygen saturation measured with pulse oximetry (SpO2) is overestimated in the presence of carboxyhaemoglobin (COHb). Smoke produced during laser resection of tracheobronchial malignancies may increase concentrations of COHb. We have measured COHb concentrations in 14 patients undergoing laser resection and compared SpO2 with functional oxygen saturation (SaO2) to ascertain if pulse oximetry is an accurate monitor of oxygen saturation. During the procedure frequent changes occur in ventilatory mechanics. Arterial blood-gas tensions were measured to see if gas exchange was satisfactory. Mean preoperative COHb was 1.4%. There was no significant change in COHb in any patient at any stage during treatment. The highest value was 2.05%. The mean difference between SaO2 and SpO2 was 1.13% (95% confidence interval 0.70-1.56%). Oxygen saturation may therefore safely be monitored by pulse oximetry in patients managed by our technique. Empirical setting of a jet ventilator provided acceptable blood-gas tensions, although sometimes it was necessary to increase the FlO2 to greater than 0.3 to maintain oxygenation.
Adult↗
Dieting concerns of 10-year-old girls and their mothers.
The responses of a group of 10-year-old girls on a dietary restraint questionnaire described a wide range of dieting concerns. Subgroups of highly restrained and low-restrained girls were identified and their mothers interviewed. A strong relationship (r = .68) was found between the degree of dietary restraint expressed by the girls and their mothers. The highly restrained girls had a significantly higher EAT score than the low-restrained girls, and shared with their mothers a susceptibility to the disinhibitory effects of negative mood states on their eating behaviour.
Anorexia Nervosa↗
Carrier estimations in Duchenne muscular dystrophy families in Northern Ireland using RFLP analysis.
Intragenic RFLP analysis was used to provide carrier risk estimations on 100 possible female carriers from 22 Duchenne muscular dystrophy families. This enabled 78% of possible carriers to be assigned high or low risks (greater than 90% or less than 10%) as opposed to 26% assigned low risk on pedigree data alone. When a single polymorphism is not informative the use of haplotype analysis for carrier estimations is illustrated for one family.
Computers↗
Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges.
The sensitivity of the appetite system of a group of obese individuals was assessed in response to two challenges known to reduce hunger and enhance satiety in lean people. The challenges were the presentation of a caloric (high protein) load and the activation of serotonin systems. Eight obese female adults (BMI = 38) received 2 X 15 mg d-fenfluramine or placebo daily for 3 days, the study conforming to a 2 X 2 factor (drug X lunch type), double blind, repeated measures design. Three hours after dosing on day 3 they ate either a high carbohydrate (63 percent of total energy) or high protein (54 percent) lunchtime meal (the caloric load). These fixed meal challenges were equal in energy (475 kcal), weight and fat content. Ratings of hunger motivation and food preferences were tracked over the course of lunch and for a further 3 hours, at which point subjects returned for a self-selection test meal. Intakes from this second open meal revealed significant main effects of both caloric load and drug on energy intake, with the high protein d-fenfluramine combination being the most potent anorectic pairing. These findings were supported by the profiles of hunger motivation. This study has confirmed that the appetite system of these subjects was responsive to these biologically relevant challenges. The results suggest that the combination of an appetite modulating drug with specific dietary intervention may represent an effective strategy for the management of hunger arising from caloric restriction.
Adult↗
Obstructive sleep apnea syndrome.
The diagnosis and treatment of obstructive sleep apnea syndrome (OSAS) is a field of emerging interest to a wide variety of professionals, including dentists. OSAS is now widely recognized as a common clinical disorder with potentially life-threatening consequences. The syndrome is characterized by repeated episodes of upper airway obstruction during sleep. The most prominent clinical manifestations are loud snoring during sleep and daytime hypersomnelence. Bypassing the area of obstruction with a tracheostomy results in an improvement in clinical symptoms. The dentist's role may be to fit a simple mechanical device for anterior repositioning of the mandible, which recently has been introduced as a less invasive mode of treatment, when the cause is functional rather than anatomical.
Cephalometry↗
Impact of microclimate cooling in rotary-wing aircraft.
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Air Conditioning↗
Rapid analysis of a peptide by fast-atom bombardment mass spectrometry after polyacrylamide gel electrophoresis.
Gel electrophoresis has been a powerful technique for the separation of peptides and proteins for many years. After electrophoresis separation on a polyacrylamide gel, the peptide bradykinin was localized using Coomassie Blue as a staining dye. Excess dye was removed by washing the gel with water. For mass spectrometric analysis, bands containing the peptide were crushed, extracted with acetic acid and the eluent applied to the fast-atom bombardment probe. Under these conditions the protonated molecule of bradykinin was clearly observed. Also apparent were sequence ions at about the same intensity observed from authentic bradykinin.
Bradykinin↗