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Biomedical subjects

A K Banerjee

Publications and source records attributed to A K Banerjee.

At least 253 records · Page 14Linked to original sources
PubMed1989

Loss of penicillin resistance in Paracoccus denitrificans induced by mitomycin C and acridine orange.

In an attempt to eliminate the penicillin resistance gene of P. dentrificans by curing agents, such as acridine orange (AO) and mitomycin C, it was observed that AO treatment caused temporary phenotypic curing where development of sensitivity was a function of concentration of both the curing agent and benzylpenicillin. However, curing with mitomycin produced sensitive clones at a frequency of 6 X 10(-3) and two permanently cured clones were isolated. Heavy metal resistance and resistance to other drugs, however, remain unchanged in the mitomycin-cured isolate.

Acridine Orange↗
PubMed1989

Structure and expression of the glycoprotein gene of Chandipura virus.

A cDNA copy of the mRNA for the glycoprotein G of Chandipura virus, a rhabdovirus, has been cloned, sequenced, and expressed in mammalian cells. The deduced amino acid sequence of G shows that the encoded protein is a typical transmembrane glycoprotein of 524 amino acids containing a cleavable amino-terminal signal peptide, two potential N-linked glycosylation sites, a hydrophobic membrane anchor domain near the carboxy terminus, and a cytoplasmic domain at the carboxy terminus. Somewhat unusual is the appearance of two charged amino acid residues, aspartate and arginine, within the putative membrane anchor sequence. Expression of the G gene in COS cells resulted in production of a glycosylated protein of mol wt 71,000 which was recognized by anti-Chandipura antibodies. Like the viral G protein, the expressed G contained covalently linked palmitic acid. However, unlike its vesicular stomatitis virus (Indiana serotype) counterpart, the Chandipura G protein has no potential palmitate-accepting cysteine residue within its cytoplasmic domain. Thus, the covalent attachment of fatty acid to this molecule may occur at one or both of the cysteines within the membrane anchor domain. The G protein was intracellularly transported to the cell surface and could induce cell fusion at low pH, showing that the expressed G protein was biologically active.

Amino Acid Sequence↗
PubMed1989

Ossified epidural haematoma. Report of two cases.

Two patients of ossified epidural haematoma (EDH) following ventriculoperitoneal shunt for hydrocephalus are reported. Pathogenesis of an ossified EDH is discussed with special emphasis on post-shunt chronic EDH.

Adult↗
PubMed1989

Malignant schwannoma of brachial plexus presenting as spinal cord compression.

A 40-year-old male presented clinically with features of C6 radiculomyelopathy. An intradural extramedullary malignant schwannoma was removed at laminectomy. Foraminal extension of the tumour could not be removed in spite of foraminotomy, and no root attachment was found. Frequent intraspinal recurrences were treated with local resection. Delayed appearance of a supraclavicular mass, CT scan and exploration of supraclavicular fossa disclosed its origin from the upper trunk of brachial plexus.

Adult↗
PubMed1989

Effect of insulin induced hypoglycaemia on in vitro uptake of 3-O-methylglucose by rat jejunum.

Acute hypoglycaemia (less than 2.0 mmol/l) selectively increased in vitro 3-O-methylglucose uptake by rat jejunum. In contrast, uptake of 3H-phenylalanine or 59Fe (III) was unchanged in the hypoglycaemic animals. The hypoglycaemia was accompanied by decreased tissue adenosine nucleotide energy charge. The increased uptake was phlorrhidzin-inhibitable and therefore reflected increased Na+ dependent glucose carrier activity. Cycloheximide did not block the increased 3-O-methylglucose uptake, implying that the mechanism is not the result of increased de novo carrier protein synthesis.

3-O-Methylglucose↗
PubMed1989

Cerebrovascular disease in north-west India: a study of necropsy material.

The pattern of cerebrovascular disease in North-West India has been studied in a necropsy series of 362 cases over a 14 year period. One hundred and thirty eight cases of intracranial haemorrhage were found, 89 of cerebral embolism, 101 of cerebral arterial thrombosis and 34 of cerebral venous thrombosis. Nearly 37% of the affected patients were below 40 years of age. Cerebral embolism and cerebrovenous thrombosis were important causes of stroke in the young. Rheumatic heart disease and infective endocarditis formed the major causes of cerebral embolism. Cerebral venous thrombosis associated with pregnancy and puerperium was relatively more common in our series than has been reported in the West.

Adult↗
PubMed1989

Visual hallucinations in the elderly associated with the use of levodopa.

Visual hallucinations are a well recognized unwanted effect of treatment with levodopa. Although many individual cases have been reported, there has only been one review previously published about this finding, and this did not discriminate age groups. We present five cases and briefly review the literature. It is important to enquire specifically about visual hallucinations in patients on levodopa therapy at follow up, as this otherwise potentially reversible side effect may be overlooked.

Aged↗
PubMed1989

Smoking habits of elderly diabetic patients.

The results of a survey of smoking habits in elderly diabetic patients are presented. Our survey suggests that most elderly diabetics are non-smokers and that the latter group are less likely to require insulin than their smoking counterparts. The majority of patients who gave up smoking following the diagnosis of diabetes did so following their doctor's advice and we suggest that all diabetic patients should be discouraged from smoking by their doctors.

Aged↗