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Biomedical subjects

A K Mathur

Publications and source records attributed to A K Mathur.

At least 55 records · Page 3Linked to original sources
PubMed1987

Diuretic effect of metoprolol.

Metoprolol caused a significant (P less than 0.001) increase in urine output in rabbits. There was no change in serum sodium concentration but serum potassium levels increased significantly. The most probable mechanism of action was increase in renal blood flow and glomerular filtration rate.

Animals↗
PubMed1987

Safety evaluation of a barrier cream.

A barrier cream containing propylene glycol, silica, xylene, dioctyl adipate and amyl acetate was applied topically for 3 months in 3 species of animal. Patch tests were carried out in human volunteers up to 72 h. The cream produced slight erythema in rats, guinea pigs and rabbits, but the irritation indices remained within safe limits. Histologically, mild focal thickening and moderate thickening of stratum corneum were observed in rats and guinea pigs, respectively, after 3 months of daily application. Patch testing in human volunteers indicated that the barrier cream is reasonably safe for human use.

Adipates↗
PubMed1986

Drug interaction between metoprolol and chlordiazepoxide.

We studied the effect of concomitant administration of chlordiazepoxide on the negative chronotropic effect of metoprolol in rabbits. Chlordiazepoxide administration for more than two weeks partly reversed the effect of metoprolol in three out of five rabbits, probably through hepatic enzyme induction.

Animals↗
PubMed1985

Genesis of lithium-induced T wave flattening.

We studied the effect of oral potassium supplement alone and with spironolactone on the lithium-induced T wave change in rabbits. T wave flattening produced by lithium was not affected by oral potassium supplementation. Oral spironolactone therapy effectively reverted as well as prevented lithium-induced T wave flattening.

Animals↗
PubMed1984

Effect of metal chelators on excretion and tissue levels of essential trace elements.

The influence of one, three, and six doses of ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), and triethylenetetramine (TETA) on the urinary excretion of Ca, Cu, Fe, and Zn, and on their levels in liver, kidneys, heart, and serum in rats, was investigated to ascertain their suitability in amelioration of metal intoxication. While excretion of all the essential trace metals examined was enhanced significantly, the tissue and serum levels of some of them either increased or decreased after administration of the chelators. The results suggest depletion of some of the endogenous trace metals from the body and their intertissue redistribution following treatment with these chelating agents.

Animals↗
PubMed1984

Protective effect of metoprolol on emetine induced T wave changes in animals.

We studied the protective effect of metoprolol on emetine induced T wave changes in rabbits. None of the rabbits who were beta-blocked before administration of emetine develop the T wave changes observed consistently in the control group. These observations support our clinical impression that emetine-induced T wave changes are produced because of stimulation of peripheral sympathetic nervous system and can be effectively prevented by prior and concomitant beta-blockade.

Animals↗