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Biomedical subjects

A K Reeter

Publications and source records attributed to A K Reeter.

4 recordsLinked to original sources

Rapid fluid replacement for severe hypovolemia--human subject trials.

Successful resuscitation of a hypovolemic patient often requires rapid intravenous administration of massive amounts of fluid. A new fluid system, incorporating a 14 French percutaneous catheter and a fluid reservoir, was recently developed and successfully tested in animals. We report the system's use in five patients with severe hypovolemia following trauma. In two cases, the experimental high-flow system successfully resuscitated the patients, allowing them to be transferred for further care. Problems associated with the use of the system included complications with central line placement and physician acceptance. This system offers an alternative that delivers these fluids in one line at rates above most current commercial systems.

Fluid Therapy

Comparison of flow rates for standard and large-bore blood tubing.

One of the clinically significant rate-limiting components in even the fastest of intravenous (IV) fluid systems is the tubing connecting the IV catheter to the IV solution container. We evaluated the effect large-bore tubing has on reducing this limitation on fluid flow, measuring gravity and pressurized flow in standard and large-bore tubing alone and when each was connected to an 8 French and 12-,14- and two types of 16-gauge catheters. When combined with an 8 French catheter, large-bore tubing produces a 126% increase in flow under gravity and a 90% increase under pressure. The improvement with the large tubing was less significant as the catheter size decreased. Studies in normovolemic adult volunteers achieved similar results. Large-bore blood tubing and large-bore catheters should be used in all situations where the need for rapid fluid replacement is contemplated.

Catheterization

Rapid fluid replacement: a new methodology.

The ability to replace fluids rapidly is frequently the limiting factor in the survivability of trauma patients. We describe a fluid infusion system that provides approximately a fourfold increase in flow rates over currently available percutaneous systems. It incorporates a 14 French (4.5-mm internal diameter) catheter introduced into a central vein by the Seldinger technique, and a manifold that allows fluid from five separate IV bags to flow into the patient through one line. In vitro tests demonstrated a gravity flow rate of more than 850 mL/min normal saline and a flow rate under pressure of more than 2.0 L/min. Packed red blood cells diluted to 42% hematocrit flowed at 1,725 mL/min under pressure. In vivo testing in dogs demonstrated a maximum gravity flow rate of approximately 650 mL/min, and a pressurized flow rate of more than 1,600 mL/min normal saline. No unusual sequelae of large-bore catheterization were detected.

Animals