[Choice of plasma substitute in massive hemapheresis].
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Biomedical subjects
Publications and source records attributed to A L Kostiuchenko.
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Main stages of artificial nutritional support (ANS) in the surgical clinic are considered as a scientific system of diagnostic and curative measures. Principle aspects of trophological screening of the surgical patient are elucidated. The algorithm of choice of the principle of ANS is presented: parenteral and enteral. Grounds are given to confirm the priority of the enteral method of ANS at the main stages of managing the surgical patient: before operation, during it, at the early and late postoperative periods.
Based on 210 cases of putting polyurethane catheters through the subclavian vein the authors substantiate the significance of the catheter material for the development of the most frequent complications. In addition to the absence of clinically diagnosed thrombotic complications, the advantages of this material were confirmed in US investigation of tributaries of the vena cava superior in 27 patients with polyurethane cava catheters staying in the same position during 3 weeks. In all the patients there were no signs of a reaction of a central veins to the catheter.
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Analysis of different aspects of application of extracorporeal hemocorrection (EH) in psychiatric practice allows to make a conclusion about the necessity of a differential approach to the use of isolated and combined procedures. The latter were assessed by the results of combined treatment of 226 patients. Indications and contra-indications for EH use in psychiatric practice are outlined.
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Based on the literature data the author analyzes the potentials, indications and principles of the parenteral alimentation of surgical patients. Possible complications and measures for their prevention are discussed.
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The key problems are pointed out depending in their solution on the understanding by clinicians of different aspects of enteral artificial nutrition (EAN) as a variant of nutritional maintenance in practical surgery. These problems are: maintenance of performing EAN with the creation of the optimum nutrition tract; choice of the nutrition substrate sources for EAN; medicines accompanying EAN. The tasks of its maintenance are to provide the access to digestive tract, supply and equipment for EAN. The basic, actual and subsidiary variants of the nutritional maintenance are considered from the viewpoints of choosing means for EAN. Six classes of nutritional mixtures are described as means for the basic nutritional maintenance. Main directions for medicamentous support are presented: optimization of properties of the nutritional mixture and overcoming possible functional complications of EAN.
The data of clinical current of sepsis in 239 wounded with syndrome of system inflammatory reaction (SIR) are investigated. Frequency of sepsis in complications of gun-shot wounds has made 5.4%. At the same time syndrome SIR is diagnosed in 23.4% of cases, that was the indication to realization of the whole complex of antiseptic treatment. Therapy of sepsis included some components: drainage and removal of the septic center; the system antibacterial therapy; the controlled hypocoagulation; immunotherapy; active detoxication; power and trophic support on the basis of balanced feed. The used principles of early diagnostics and multicomponent therapy of surgery of sepsis have allowed to lower lethality up to 29.3% and in sepsis of wound--up to 9.1%.
544 patients resistant to pharmacotherapy were treated by different methods of extracorporal hemocorrection (EH). Positive changes in mental state were achieved in more than half of the patients by means of EH without any psychopharmacologic drugs. These changes were caused by antipsychotic and antidepressive effects of EH as well as by its ability to normalize biochemical, immunological and rheological blood indices
35 procedures of plasmofiltration were conducted on the test series of domestic membrane plasmofilter in 25 patients suffering from atopic diseases, systemic affections of connective tissue, advanced atherosclerosis, etc. The filter proved promising in therapeutic patients. The procedure is easier to perform compared to centrifuge plasmapheresis, it can work under thin blood flow. However, centrifuge plasmapheresis has advantages over the above filtration in patients with hyperhydration, hemorrhagic syndrome, contraindications to large-dose anticoagulants.
Application of antihypoxant drugs in postoperative period has been investigated. Lithium oxybutyrate was administered to 30 lung cancer patients before and shortly after operation. The results were compared with the data on 26 patients in control. Major characteristics, and, primarily, its antihypoxic protective effect have been evaluated. Lithium oxybutyrate administration is recommended in lung cancer patients during and shortly after surgery.
An estimation of changes of main hemodynamic, biochemical and laboratory indicators and the function of external ventilation was fulfilled when performing temporary endobronchial occlusion at the level of lobular and main bronchi in 37 patients with pneumothorax. Favorable changes were established in the systems of blood circulation and external ventilation in occlusion of lobular bronchi. Grounds are given for the necessity of intensive anti-inflammatory treatment, oxygenation and maintenance of cardiodynamics in occlusion of the main bronchus.
The effect of various types of operative interventions on the course of the early postoperative period was studied in 419 patients with duodenal ulcer. The blood biochemical values and hemodynamic parameters were studied. The indications for operation were absolute in 128 and relative in 291 patients. It was established that under conditions of a specialized medical institution the negative aspects of surgical treatment of duodenal ulcer may be brought to minimum both in patients with absolute and in those with relative indications for operation.
The authors show that application of anticipated postoperative intensive care gives the possibility ot obtain more complete effect of compensation. The basic components of this therapy are the following: removal of hypovolemia and anemia, combined (central and regional) anesthesia, prevention of pneumonia, normalization of salt and water exchange, removal of excessive catabolism, adequate ensuring of organism with energy and plastic material for long-time compensation, prophylaxis and treatment of paresis of digestive tract, chemoprophylaxis of wound infection. The proposed program of intensive therapy gives the possibility to minimize the lethality among wounded with penetrating abdominal gunshot injuries and can be used as a basic one for the development of various schemes of intensive therapy for other categories of wounds.