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Biomedical subjects

A Leclerc

Publications and source records attributed to A Leclerc.

104 records · Page 6Linked to original sources
PubMed1981

[Differentiation factors concerning the declaration of symptoms (author's transl)].

A survey has been carried out (in suburbs of Paris) on the cultural factors of differentiation concerning the opinions and the attitudes of people towards health and disease; it was an opportunity to ask questions about present and old symptoms felt by the person who had answered. The main points which result from a multivariate analysis, carried out in order to study the relation between the symptoms' declaration and the selected and sampling variables, are the following: --There is a privileged relation between the female sex and everything affecting diseases and health, through the trend of declaring symptoms. --Besides, the trend of declaring symptoms is generally on a par with the steady existence of psychological symptoms. --For the same number of symptoms declared, these are the youngest and the most educated and, especially, those who accept the idea that a "mental disorder" can happen to them, who declare the highest number of psychological symptoms and, therefore, less organic symptoms. Four main factors are arising: the sex, the social class which some one belongs, individual psychological factors and the personal health status. An analysis is proposed, concerning the main relations which become obvious.

Adult↗
PubMed1981

[Mortality: comparison of mortality between a specific industry and the French population (author's transl)].

Mortality statistics are underutilized in France. Authors show that it is possible to use them for small population (125 000). Classical statistical methods are utilized. The interpretation of the results is difficult with regard to the quality of National data. Comparison data conclude that mortality rates are lower within the industry for lung and gastrointestinal disease, suicide, injuries and that three health problems are more prevalent: alcholism, injuries for young men and cancer.

Accidents, Occupational↗
PubMed1980

Separation of epoxy-embedded cell cultures from plastic flasks for electron microscopy.

Monolayers of cells grown in ordinary plastic flasks are fixed and embedded "in situ" into Epon. When polymerized at 40 C for 4 days instead of the usual 60 C, the Epon sheet containing the cells is easily detached from the bottom of the plastic container. The Epon sheet is observed by light microscopy as a histological preparation. Ultrathin sectioning of preselected areas can then be carried out in a horizontal plane.

Animals↗
PubMed1979

[Morbidity, mortality and social class. Bibliographical review covering differents aspects of pathology, and discussion (author's transl)].

A bibliographical review of social differences in morbidity and mortality is presented. The data concerns France, Great Britain and U.S.A., only for recent years, and come from large surveys, health examinations, or morbidity or mortality registers. The social class variable may be the educational level, or a professional classification. Different aspects of mortality and morbidity are examined: cancer, cardio-vascular diseases, respiratory diseases, musculo-skeletal diseases, digestive diseases, obesity and diabetes, accidents, mental illnesses; acute and minor illnesses, and unusual illnesses, are no studied. For almost all the diseases in this review, the risk is greater in the lowest socioeconomic class.

Accidents↗
PubMedDate not supplied

Risk factors for simultaneous carcinoma of the head and neck.

The upper aerodigestive tract is a preferential site for multiple primary cancer. The purpose of this study was to determine the characteristics of patients presenting with at least two simultaneous cancers of the upper aerodigestive tract compared with patients with a single location. Men patients (2,738) with squamous cell carcinoma were enrolled in the study. Of these, 120 (4.4%) presented with at least 2 simultaneous cancers (cancers detected within a 6-month period). The group of patients with simultaneous cancers was compared with a group presenting with a single location. Two factors (the mean daily alcohol consumption and employment as a "blue-collar" worker at any time during the working life) seem to be related to the occurrence of simultaneous cancers.

Aged↗
PubMedDate not supplied

Geographical distribution of respiratory cancer in New Caledonia.

All cases of primary respiratory cancers diagnosed between 1/1/78 and 12/31/81 in the French territory of New Caledonia, where nickel has been mined and smelted for more than one hundred years, were recorded. The successive addresses of each case were noted. The distribution of stays between mining zones and others was compared to an expected distribution based on censuses. A significant excess was observed in mining zones, both for the number of stays and for the number of person-years. The excess was observed for primary lung cancer only. The data seem to indicate that people with lung cancer have spent a larger part of their life in a mining zone. The reason for that phenomenon cannot, however, be assessed clearly. This could be due to the geographical environment, i.e., the presence of nickel and asbestos in the soil of some parts of the territory; the observed relationship could also be due, in part, to the effects of urbanization leading to increased tobacco consumption.

Epidemiologic Methods↗
PubMedDate not supplied

Cost and cost effectiveness of the mechanical and pharmacologic bridge to transplantation.

A prospective study has been carried out to evaluate the cost and cost effectiveness of the mechanical bridge (MB) or pharmacologic bridge (PB) to transplantation (HTx) in patients referred in cardiogenic shock (CS), who are candidates for Htx unresponsive to sympathomimetics. Selection between MB and PB was based on immediate efficacy of i.v. enoximone (2 mg/kg/BW) therapy. From 1986 to 1989, 37 patients who should have been immediately treated by MB entered the protocol. Six were unresponsive and rapidly received a Jarvik heart or left ventricular bypass (MB). Thirty-one improved (PB), with the need for HTx reconfirmed in 22 and performed in 14. Survival of the entire group was 70% and 51% at 1 and 3 months, respectively. Cost per patient was $45,843 ranging from 38,326 in PB patients to $84,683 in MB patients. Cost per patient transplanted after PB was $50,745. Cost per survivor at 1 year was $210,000 for all, ranging from $254,000 in MB to $192,455 in PB. Cost per added day of survival was higher in MB (+ 228%) at 1 month compared to PB. The difference was reduced at 1 year.

Adult↗
PubMedDate not supplied

A simple photometric microassay for the quantitative evaluation of macrophage-mediated cytotoxicity on adherent cancer cells.

A new in vitro microassay was devised for the quantitation of macrophage-mediated cytotoxicity on cancer cells. After 72 h of culture with macrophages, the residual adherent target cells were stained with methylene blue. The cell-bound dye was then eluted and measured in a photometer. This assay is simple, quickly performed and gives reproducible results in good correlation with direct counting of the residual cells. It allows a quantitative evaluation of the whole toxic effect (cytostasis and cytolysis) of activated macrophages on adherent tumour cells.

Animals↗