Biomedical subjects

A Leoni

Publications and source records attributed to A Leoni.

75 records · Page 5Linked to original sources

PubMedDate not supplied

Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones.

The Knoevenagel reaction between 2-indolinones and 2-chloroindolaldehydes gave 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones which were tested as potential antitumor agents on cultures of HeLa cells. 2-Chloro derivatives with at least one unsubstituted NH group, are promising candidates for further investigation.

Antineoplastic Agents↗

PubMedDate not supplied

[Current role of dynamic computerized tomography in preoperative staging of gastric carcinoma].

In the preoperative staging of gastric cancer, dynamic CT appears essential for tumors of the cardia and fundus, and, for the other cases, useful in detecting a possible involvement of adjacent organs or lymph nodes.

Humans↗

PubMedDate not supplied

Potential coanthracyclinic activity of pyridylmethylene-2-indolinones.

The paper reports the cytotoxic activity of pyridylmethylene-2-indolinones previously described as cardiotonics and the synthesis of three analogs of the most potent cytotoxic agent. Some of these compounds could be useful, when associated with anthracyclines, to reduce the cardiotoxicity of these potent antitumor drugs.

Antineoplastic Agents↗