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Biomedical subjects

A M Perry

Publications and source records attributed to A M Perry.

6 recordsLinked to original sources
PubMed1989

Stereotactic radiosurgery.

Stereotactic radiosurgery is the accurate focusing of ionising radiation onto an intracranial target, and was pioneered in Sweden in the early 1950's. It has proven effective in the treatment of arteriovenous malformations, acoustic tumours and many other small brain lesions. In the last decade the commercial availability of a gamma ray system has led to other centres following the work in Stockholm; more recently, various techniques utilising linear accelerators, (LINACs), have been developed. Both types of system necessitated special dosimetry and treatment planning methods for the small, high dose-gradient circular fields. Localization of the lesions requires angiography, computerised tomography (CT) or magnetic resonance imaging (MRI).

Brain Diseases↗
PubMed1979

Investigation of time-gap formulae on the CRE system using mouse tissue as a biological model.

The cumulative radiation effect (CRE) is one of several empirical scalar descriptions of biological effect which enable corrections to be made for gaps in radiotherapy treatment. Predictions of this theory were tested using mouse crypt regeneration and mouse skin as biological models. These experimental results are discussed in terms of the dependence of tissue regeneration potential during a gap on the biological effect achieved before the gap, and on gap length. A hypothesis is proposed to reconcile the apparent conflict between the two experiments. While the simple exponential gap formulation of the CRE is seen to be inadequate, insufficient data are available at present to modify it.

Animals↗
PubMed1977

An assessment of a non-invasive technique for measuring deep body temperature.

The assessment of a non-invasive technique for measuring deep body temperature is described. An experimental system, in which the insulating effect of subcutaneous fat thickness could be simulated, was designed to test the deep body thermometer (DBT). The assumption that the instrument produced zero temperature gradient was found to be incorrect, and a mathematical model was developed which showed that the cyclically varying output of the device is an inherent property of its design. The accuracy and response time were investigated as a function of tissue thickness to assess the instrument's clinical usefulness.

Adipose Tissue↗