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PubMed · 6283794

Dose response experiments using the mouse tail model.

J Kirk·A M Perry·B R Cater
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Abstract

Radiation induced tail necrosis in BALB/c mice was used to investigate the effects of tissue temperature and local oxygenation on the radiation response. Single doses of 250 kV roentgen-rays were given over the temperature range 32.5 to 37 degrees C and dose response curves obtained. The temperature dependence of the response was shown to be consistent with changing hypoxic status by the derivation of a simple model; this has practical implications for the treatment of patients using simultaneously combined radiation therapy and hyperthermia.

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AnimalsBody TemperatureDisease Models, AnimalDose-Response Relationship, RadiationHot TemperatureMiceMice, Inbred BALB CNecrosisOxygenProbabilityRadiotherapyTailJournal Article

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J Kirk, A M Perry, B R Cater. 1982. Dose response experiments using the mouse tail model.. https://doi.org/10.3109/02841868209133980

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