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Biomedical subjects

A M Romanenko

Publications and source records attributed to A M Romanenko.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Morphology and histogenesis of yolk sac tumors in the testis].

The differentiation of yolk sac tumor cells was similar to the processes of development of embryonic and extraembryonic endoderm during the first 7 wk after cleavage. Two ways of yolk sac tumor histogenesis are discussed: differentiation of embryonal carcinoma cells, and redifferentiation of the polypotent undifferentiated anaplastic seminoma cells. Histogenesis features described may be responsible for aggressive nature and high malignancy of yolk sac tumors.

Cell Differentiation↗
PubMed1986

[Histogenesis of human embryonal cancer of the testis].

Complex morphological study of 45 germ cell tumors of the testis revealed two types of histological structure of embryonal carcinoma. Tumour histostructure was related to the ultrastructural features of cells (I-IV types) forming them. The data obtained indicate that the process of differentiation of these tumours resembles initial stages of embryogenesis (morula, blastula, egg cylinder). Embryonal carcinoma cells appeared to be tumor stem cells in the development of teratoma, chorionepithelioma, yolk sac tumour.

Embryonal Carcinoma Stem Cells↗
PubMed1986

[Electron microscopy in the diagnosis and prognosis of transitional-cell bladder tumors].

The electron-microscopic analysis of 65 different transitional-cell tumours of the urinary bladder revealed quantitative correlations between the tumour cells belonging to different groups, types and forms of transitional-cell papilloma, transitional-cell carcinoma and undifferentiated carcinoma of the bladder. These correlations are of importance for histogenetic and differential diagnosis of these tumours. The correlation between the changes in cell composition of transitional-cell papilloma or transitional-cell carcinoma and the subsequent clinical course of the disease (prognosis) is determined.

Carcinoma, Transitional Cell↗
PubMed1986

[Clinico-morphological characteristics of bladder leukoplakia].

A clinico-morphologic study was carried out in 63 patients suffering from leukoplakia of the urinary bladder. Certain differential diagnostic characteristics of clinical course and cystoscopic pattern of the disease as well as morphologic features of squamous cell metaplasia were identified. Malignant leukoplakia was registered in 12%. Papilloma and cancer concomitant to leukoplakia were detected in 22 and 27%, respectively.

Adult↗
PubMed1985

[Leukoplakia of the bladder].

The urinary bladder leukoplakia from 42 patients was studied clinico-morphologically, histochemically and electron microscopically. This precancerous condition is observed in 58,3 cases of chronic cystitis, more frequently in females. Three successive stages of the leukoplakia development under the conditions of the inflammatory process can be distinguished: squamous-cell modulation, squamous-cell metaplasia, squamous-cell metaplasia with keratinization. The formation of fissure-like intercellular bridges and the appearance of the long dense bundles of tonofibrils in the cytoplasm are the early ultrastructural signs of squamous-cell metaplasia of the transitional epithelium which are of the differential-diagnostic importance.

Adult↗
PubMed1985

[Morphology of precancerous mucosal changes in the bladder].

A morphological analysis of 346 biopsy specimens from 140 patients with chronic cystitis permits one to evaluate a nonproliferative and proliferative forms of the disease as well as the squamous-cell metaplasia (leukoplakia) of urothelium as the risk diseases in the development of bladder cancer. Among them only the cases with dysplasia foci of urothelium or the squamous-cell metaplasia with acanthosis or dysplasia from the risk group belonging to bladder precancer. The early ultrastructural signs of urothelial dysplasia are determined; among them the proliferation of the undifferentiated cells with an increased nuclear-cytoplasmic ratio, the disappearance of asymmetrical mutual membrane, vesicular apparatus and cytoplasmic polarity of the superficial cells are to be distinguished.

Biopsy↗
PubMed1984

[Clinical course and morphological characteristics of different types of seminoma].

A comparative analysis of morphological peculiarities and clinical course of seminoma makes the case for distinguishing three types of the tumor. Prognosis in cases of typical seminoma depends on the level of differentiation of tumor cell elements and stage of tumor. Alkylating drugs and radiotherapy should be a method of choice in treatment of patients with typical seminoma. High orchofuniculectomy may be sufficient at the initial stages of spermatocytic seminoma due to its favorable clinical course determined by a high level of specific differentiation of tumor cells. Electron microscopic analysis of anaplastic seminoma showed cells with signs of differentiation towards trophoblast (chorionepithelioma elements) and embryonal entoderm (yolk sac tumor) characterized by a relatively higher malignancy. These data account for the tendency of anaplastic seminoma to rapidly disseminate and suggest application of adjuvant chemotherapy and lymphadenectomy.

Adolescent↗
PubMed1983

[Ultrastructure and histogenesis of spermatocytic seminoma].

Electron microscope study of spermatocytic seminoma revealed cells at various stages of differentiation. The generally high level of cell differentiation suggested the advancement of the process in the said neoplasms. A comparative study of normal spermatogenic epithelium and spermatocytic seminoma showed a resemblance of tumor cell differentiation and spermatogenic epithelium development. These common features included filament structure formation, characteristic of primary spermatocyte at leptonema stage of meiosis, formation of ponticuli intercellulares and the increased level of complex lamellosus elements. Spermatocytic seminoma seems to result from malignant transformation of progenitor cells-spermatogonii B. This accounts for the high degree of specific cell differentiation of tumor, as compared with standard seminoma.

Dysgerminoma↗
PubMed1982

[Role of atypical sex cells in the histogenesis of germinative testicular tumors].

Histochemical and electron microscopic study of 23 germinative tumors of the testicle and organ tissue beyond the tumor was carried out. In 78% of the observations, normal seminiferous tubules were found to contain a special kind of cell elements, atypical sex cells (ASC), not observed in health. Ultrastructural and histochemical features of undifferentiated cells comprising seminoma and embryonal cancer were found to be similar to those of ASC and gonocytes of human embryo. The results suggest that ASC are the stem tumor cells for human germinative neoplasia which are characterized by single cytohistogenesis.

Cell Differentiation↗