PubMed Health⌕ Search

Biomedical subjects

A M Soliman

Publications and source records attributed to A M Soliman.

At least 19 recordsLinked to original sources
PubMed2001

Changing trends in angioedema.

Angioedema can be a life-threatening event presenting to otolaryngologists, emergency medicine physicians, and other physicians. Recent reports suggest an increasing role of angiotensin-converting enzyme inhibitors (ACEIs) in the causation of angioedema. Sixty-four cases occurring between 1994 and 1998 were identified and examined retrospectively. Fifty-eight percent of patients presenting with angioedema were using ACEIs. Ninety-four percent of patients overall, and 92% of patients with ACEI-associated angioedema, were African-American. Tongue, lip, facial, and supraglottic edema were most common. Treatment included intubation in 13% and intensive care unit monitoring in 20%. Nearly all patients were treated with corticosteroids and antihistamines. There were no deaths. Angioedema associated with ACEI use appears to be much more common than previously reported. African-American patients may be at higher risk for angioedema with ACEI use. Successful management was achieved with observation, expectant airway management, corticosteroids, and discontinuation of ACEIs. Patients without airway obstruction or pharyngeal or laryngeal edema who improved with treatment and observation were successfully treated as outpatients.

Adult↗
PubMed2000

A new flavonoid from Limonium axillare.

A new flavonol glycoside identified as myricetin 3-O-beta-D-sorboside (1) has been isolated from the leaves of L. axillare. The new compound showed a moderate inhibition of Ehrlich ascites carcinoma cells.

Animals↗
PubMed1999

Cell adhesion molecules in normal laryngeal development.

Larynges taken from normally developing rats ranging from embryos starting at embryonic day 10 to adults were harvested. Sections of the larynges were prepared with the use of immunohistochemical techniques with primary antibodies directed to the neural cell adhesion molecule; selected sections were exposed to antibodies directed against the embryonic polysialated form of the neural cell adhesion molecule and against L1. Cell adhesion molecules were present throughout embryonic development associated with the recurrent laryngeal nerve. Downregulation of expression was observed after postnatal day 14. We conclude that cell adhesion molecules may play a role in the normal neural development of the larynx in rats.

Animals↗
PubMed1997

Autoantibodies in inner ear disease.

The etiopathogenesis of many inner ear disorders still remains idiopathic. Immunological mechanisms are attracting attention in relation to a number of these diseases. Some cases are believed to be autoimmune in origin. The present study was conducted to determine whether patients with inner ear disorders produce antibodies that may be pathologic to the inner car or result from its damage. Sera from 100 patients with various inner ear disorders were tested for autoantibodies using the indirect immunofluorescence test. Inner ear tissue preparations from healthy guinea pigs were used as antigen substrates. Adequate tissue and serological controls were applied. Two groups of antibodies were detected; antibodies directed against the inner ear tissues (18%) and antibodies directed against different tissue/cellular elements (41%). A wide variety of inner ear antibodies were found, though no common type manifested itself. Meniere's disease was the most common clinical diagnosis in the antibody-positive group.

Antibody Formation↗
PubMed1997

Traumatic auricular hematoma: a case report.

Traumatic recurrent auricular hematoma can be a challenging medical problem, with complications resulting in cauliflower ear. Proper management often depends on an understanding of the pathophysiology and pathogenesis of fibroneocartilage--an abnormal fibrous cartilage formation in response to injury. Traditional treatment by incision and drainage, and compression dressing technique may be inadequate in the setting of recurrent or chronic hematoma. Instead, excision of the fibroneocartilage is essential in promoting hematoma resolution and wound healing. Appropriate treatment of auricular hematoma can reduce needless cosmetic deformity and can avoid difficult secondary reconstruction. The authors present a case of recurrent auricular hematoma and review its pathophysiology and current therapy.

Bandages↗
PubMed1996

A subpopulation of Menière's patients produce antibodies that bind to endolymphatic sac antigens.

The endolymphatic sac (ES) has been suggested to serve an important immunological role within the inner ear. Meanwhile, immunological mechanisms have been studied in connection with Meniere's disease. The aim of this study is to look for and recognize antibodies against the ES in the sera of patients with Meniere's disease, using the technique of indirect immunofluorescence. Sera from 50 patients with Meniere's disease, from an animal model of autoimmune inner ear disease, and from healthy controls were tested against ES tissue substrates obtained from guinea pigs. Immunoglobulin deposition in the ES was found in 20 patients (40%) compared with one control (10%). The difference was statistically significant when computing the odds ratios at 95% confidence level. Fluorescein labeling was demonstrated in the ES epithelium in 16% and in the surrounding perisaccular stroma in 24%. Identical immunoreactivity against the ES tissue was depicted in the sera of the experimental animal model. These findings support the possibility of humoral immunological involvement in the Meniere's disease process. Immunological derangement of the ES function could be the first step in a cascade of reactions leading to endolymphatic hydrops and presenting as Meniere's disease.

Antibody Formation↗
PubMed1992

Studies on carbohydrates extracted from native and chemically treated Biomphalaria alexandrina snails.

1. Carbohydrates were extracted from total tissue extracts of Biomphalaria alexandrina snails and were analyzed to their monosaccharides using GLC. 2. The snails were chemically treated with thioxanthone derivatives (compounds I, II, III) and the change in the monosaccharide constituents of their carbohydrates was investigated. 3. The isolated monosaccharides from native and chemically pretreated snails were injected into mice and their protective effects were examined after infection of mice with cercariae of Schistosoma mansoni. 4. The results showed that the main monosaccharides in carbohydrates of snails were galactose, glucose, fucose and mannose and that chemical treatment caused a drop in the galactose content. 5. Moreover, monosaccharide fractions from snails treated with compound III were the most effective in inducing protection against Schistosoma infection in mice.

Animals↗
PubMed1992

Immune-mediated inner ear disease.

Recent clinical studies, experimental research, and various testing techniques in otoimmunology have resulted in presentation of the synonymous terms autoimmune sensorineural hearing loss, autoimmune inner ear disease, immune-mediated sensorineural hearing loss, and immune-mediated inner ear disease or disorder. The development of this terminology and the clinical presentation of this disease as well as whether it is really a distinct clinical entity are discussed. Laboratory tests for immune-mediated inner ear disease are presented along with a discussion of progress being made in the growing field of otoimmunology.

Antigen-Antibody Complex↗
PubMed1990

Type II collagen-induced inner ear disease: critical evaluation of the guinea pig model.

Guinea pigs systematically challenged with type II collagen were examined electrophysiologically, histologically, and immunologically for inner ear lesions. Some functional, morphologic, and immunologic changes could be demonstrated. Evidence of possible immunoglobulin deposition in the basilar membrane, the perivascular region, as well as in other inner ear tissue were present. Immunologic and histopathologic simulations to inner ear diseases in humans and to the inner ear antigen-induced animal model were found. The results are discussed in light of the original model introduced by Yoo et al and the reexamination findings reported by Harris et al. The discrepancies in the results are argued, and the impact of this experimental model on human autoimmune inner ear disease is analysed.

Animals↗
PubMed1989

Experimental autoimmune inner ear disease.

A guinea pig animal model of autoimmune inner ear disease is presented. The functional, anatomical, and immunological inner ear changes were tested electrophysiologically, histologically and by the immunofluorescence test. Using a homologous crude inner ear antigen (CIEAg) we were able to induce endolymphatic hydrops, vasculitis, mild cellular infiltration of the endolymphatic sac, and occasional spiral ganglion degeneration. Threshold shift was seen in 20% of the tested ears. Specific fluorescence was revealed around the modiolar vessels and in the basilar membrane. The endolymphatic sac and duct showed occasional fluorescence in the epithelial and/or subepithelial layers. The findings were discussed in light of the other models immunized with various forms of inner ear antigens. Similarities between the detected specific fluorescence and the fluorescence revealed by sera of patients with cochleovestibular disorders were discussed.

Action Potentials↗
PubMed1989

Autoimmune hearing loss.

Tissue nonspecific antibodies may give an idea about the etiopathogenesis of the inner ear disease. They are of some prognostic and therapeutic value. They are routinely tested in most inner ear patients. On the other hand, inner ear specific autoantibodies do exist. Their diagnostic, prognostic and therapeutic significance are still unclear. Cellular immunity is tested only in selected cases based upon the clinical picture and the results of humoral immunity testing. It needs whole fresh blood as well as facilities not available in all laboratories. Their main role seems to be in providing solid basis for cortisone therapy justification. Our therapeutic concept proved to be promising in some cases. Immune-mediated inner ear disorders do not form a separate clinical entity. We would rather add immune mediation to the different causes postulated for the various inner ear disorders, as a plausible explanation for a certain percentage of the group categorized as idiopathic of unknown etiology.

Adult↗