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Biomedical subjects

A M Zemskov

Publications and source records attributed to A M Zemskov.

At least 73 records · Page 4Linked to original sources
PubMed1977

[Strengthening the immune response to typhoid vaccine by subcutaneous RNA administration].

The authors demonstrated the adjuvant activity of the RNA preparations injected subcutaneously. In the treatment of mice with the vaccine with a stimulant there was increase of antibody production and of their resistance to infection with typhoid causative agent in comparison with the animals which were only immunized. When the adjuvant was used the vaccine dose could be devreased 2- to 8-fold without any reduction of the immunity formed. RNA injection to the immunized animals on the 25th day after the onset of the experiment produced a revaccinating effect.

Adjuvants, Immunologic↗
PubMed1975

[Further research on an experimental justification for the emergency prophylaxis of typhoid].

Experiments were conducted on mice. A possibility was demonstrated of express prophylaxis of typhoid fever by subcutanoues injection of the vaccine and by oral administration of sodium nucleinate, of lowering the dose by half and replacement of revaccination by sodium nucleinate alone. An increase in the titre of typhoid agglutinins and of preventive activity of the blood serum was revealed on volunteers.

Administration, Oral↗
PubMedDate not supplied

[Impaired immune response associated with ABO antigen system in patients with purulent abscesses and dysentery].

On the basis of a considerable number of facts--the results of the immunological survey of 197 patients with purulent infections of soft tissues and 103 shigellosis patients--the character and manifestation of immunological disturbances were found to depend on the genetic markers of blood (antigens of the AB0 system) which proved to differ in different type of pathology in patients.

ABO Blood-Group System↗
PubMedDate not supplied

[Correction of immunologic reactivity depending on ABO system antigens in patients with purulent infections of soft tissue and shigellosis].

The immunological study of more than 300 patients with purulent infection of soft tissues and shigellosis was carried out. The character and manifestation of the immunocorrecting action of sodium nucleinate were found to depend on the antigens of the AB0 system, which proved to be different in various type of pathology.

ABO Blood-Group System↗
PubMedDate not supplied

[Problem of specific and nonspecific factors in the induction and regulation of immunological reactions].

The functional unity of the specific and nonspecific mechanisms of immunological reactions has been shown on the basis of our own investigations and the published data. As revealed in this study, during the formation of immune response smooth transition from the nonspecific level to the specific one occurs. First, the factors of nonspecific protection are switched on, then intermediate reactions develop, further antibodies are synthesized, etc. At any level of immune response its regulation by nonspecific immunomodulators is possible, their influence controlled by a complex of reactions of the neuroendocrine system, also carrying the elements of nonspecificity and specificity.

Animals↗
PubMedDate not supplied

[Treatment of secretory otitis media].

Blood serum of 38 patients with otitis media (14 men and 24 women), aged 16 to 55 years, was examined immunologically. The patients were subdivided into two groups that received identical traditional therapy. However the Group 2 patients were also given per os 0.5 g sodium nucleinate 3 times a day for 10 days. Before and after treatment all the patients underwent immunological tests which included measurements of T- and B-lymphocytes, T-helpers and T-suppressors as well as immunoglobulins M, A, G and complement. It was demonstrated that sodium nucleinate exerted beneficial clinical and immunological effects.

Adjuvants, Immunologic↗
PubMedDate not supplied

[The effect of sodium nucleinate on allergic reactions].

Experiments on animals and clinical observations over patients with infectious-allergic bronchial asthma and rheumatism showed that sodium nucleinate could abolish or suppress the intensity of immediate and delayed type hypersensitivity and the corresponding skin reactions to specific allergens.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Tachyphylaxis].

Explore the source record for details and available documents.

Animals↗
PubMedDate not supplied

[Correction of immunologic disorders in patients with chronic suppurative otitis media].

The absolute and relative content of T- and B-lymphocytes, T-helpers (CD4), T-suppressors (CD8), phagocytosis, complement and immunoglobulins A, M, G in the blood serum was examined in patients with chronic purulent otitis media. The investigation also involved tests on immunological activity of tymoptin (T), sodium nucleinate (SN), prodigiosan (PR), the combination of SN with PR. 148 patients aged 15-56 years were subdivided into 5 groups. In pretreatment immunological status of all the patients the count of T- and B-lymphocytes, T-helpers, phagocytosis were reduced against increased counts of IgM and T-suppressora. All the patients received similar conventional treatment with adjuvant SN (group 2), PR (group III), SN + PR (group 4), T (group 5). The conventional conservative and especially surgical treatment aggravated immunodeficiency. The adjuvant immunocorrectors potentiated the treatment effects which appeared to be most beneficial in group V followed by by groups IV, II and III in diminishing order.

Adjuvants, Immunologic↗