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Biomedical subjects

A Maresta

Publications and source records attributed to A Maresta.

At least 73 records · Page 4Linked to original sources

[Percutaneous transluminal dilation by catheter of coronary - artery stenosis (author's transl)].

Since September 1977 until July 1979, 82 patients with various coronary lesions have undergone percutaneous transluminal coronary angioplasty (PTCA). By this technic, a catheter system is introduced through a systemic artery under local anesthesia to dilate a stenotic artery by controlled inflation. In 60 patients (73%) anatomical and hemodynamic success could be noted, which led to improvement in clinical parameters e.g. reduction of coronary narrowing of the transluminal diameter from a mean of 82 +/- 11% to 34 +/- 16% (p less than 0.001) and reduction of trans-stenotic coronary gradient from 56 +/- 15 to 19 +/- 12 mmHg (p less than 0.001). Nine patients, three of whom had signs of transmural myocardial infarction on the ECG had undergone emergency surgery for a coronary by-pass, this been due to the deterioration of clinical condition after the attempt to carry out coronary angioplasty. 42 out of 60 treated patients had at least one late control. 33 showed an improvement in cardiac efficiency campared with the pre-dilatation period. Patients with uncalcified single-vessel stenosis, less than 1 cm in length and a short history of pain appear to be most suitable for the procedure. More cases and follow-up datas are necessary to evaluate the efficiency of this new technic as compared with current medical and surgical treatments of ischemic heart disease.

Adult

[Comparison of the hemodynamic effects induced by dobutamine, isoproterenol and dopamine in patients with coronary artery disease (author's transl)].

The haemodynamic affects of dobutamine (DB) (5 microgram/kg/min), isoproterenol (I) (0.02 microgram/kg/min), dopamine (DP) (5 microgram/kg/min), were studied in 12 patients with coronary artery disease randomly divided in two groups of 6 patients. In one group each patient received DB and I, in the other group each patient received DB and DP. The following parameters were measured: heart rate, aortic blood pressure, left ventricular pressure, left ventricular dp/dt, pulmonary arterial and wedge pressure, cardiac output, stroke volume, peripheral and pulmonary vascular resistances. In both groups either I and DP increased significantly heart rate whereas DB did not modifie it. DB caused a larger increase of dp/dt max and of stroke volume as compared to I and DP. These data confirm that DB possesses an inotropic effect greater than I and DP without any significant positive chronotropic effect in patients with coronary artery disease.

Adult