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Biomedical subjects

A Markiewicz

Publications and source records attributed to A Markiewicz.

At least 37 records · Page 2Linked to original sources
PubMed1984

Circannual rhythm of exercise metabolic rate in humans.

Exercise metabolic rate was established by indirect calorimetry in 18 healthy subjects. Each subject was tested every month for 1 year. Four variables demonstrated a circannual rhythm and its acrophases occurred in the following months: RQ in October; exercise metabolic rate in April; acceleration of heart rate during exercise in February; percentage of body fat in August.

Adipose Tissue↗
PubMed1984

Circadian bioavailability and some effects of propranolol in healthy subjects and in liver cirrhosis.

The aim of the study was to establish whether and how circadian rhythms alter the bioavailability of, and response of circulatory and ventilatory functions to 80 mg of propranolol given at four different test times. Both Cmax and AUC were lowest at 2:00 pm as compared with other test times in healthy group (N = 6), lower in cirrhosis (N = 6), but none in portacaval shunt (N = 3). Thus, at 2:00 pm, liver extraction seems to be the best in healthy subjects, worse in cirrhotics and negligible in PC shunt. The mean AUC value in PC shunt patients was three times as high as in healthy subjects and cirrhotics. This seems to be due to the reduced first-pass extraction phenomenon in the liver in PC cases. All subjects exhibited a prompt and significant depression of radial pulse and systolic BP; this effect on radial pulse was lasting longer at 2:00 am than at other test times. The initial values of PEF were lowest at 2:00 am and no depressing effect of propranolol was observed in comparison with other test times. From the practical point of view, the changeable bioavailability of propranolol given at different times of the day has no direct consequences in regards to the temporal response to the drug in healthy subjects and cirrhotics, since it is likely that both propranolol and its metabolites (4-OHP) are active as beta-blockers. Twenty-four hour oscillations of the responses to propranolol seem to exist both in healthy and cirrhotic patients.

Adult↗
PubMed1983

Circadian rhythms of four marker enzymes activity of the jejunal villi in man.

Bioptic specimens taken from the lower duodenum were studied in 12 volunteers at different times of the day for the activity of 4 marker enzymes. The activity of alkaline phosphatase in brush border of villi was the strongest at 06h, while the nadir at 22h; acid phosphatase activity in the supranuclear zone and in macrophages was the strongest at 06h and reduced at other test times; the peak activity of 5' nucleotidase was found at 14h with the nadir at 02h; activity of NADPH was the strongest at 18h. It is suggested that circadian rhythmicity of intestinal function exists in man like in animals.

5'-Nucleotidase↗
PubMed1983

The bioavailability of three dipyridamole products.

Following oral administration of 75 mg of three dipyridamole commercial products in a three-way crossover design with six subjects, no statistically significant differences were found for serum concentrations at all sampling times nor for bioavailability parameters. The only exception was the higher serum concentration occurring 0.5 h after administration of Antistenocardin when compared with dipyridamole (p less than 0.05).

Administration, Oral↗