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Biomedical subjects

A Markiewicz

Publications and source records attributed to A Markiewicz.

At least 55 records · Page 3Linked to original sources
PubMed1979

ADH and thermal sweating.

Sweating responses to heat exposure were compared in healthy subjects pretreated with pitressin or alcohol and in the control group. Between the three groups, there were no consistent differences in the rate of sweating expressed both as a total body weight loss during 2-h heat exposure and in mg of sweat per skin area covered by a paper disc. Likewise, there were no differences in the sweat osmolality or electrolyte concentration. There was also no evidence of inverse correlation between plasma ADH level and rate of sweat secretion or its concentration when pooled data of all subjects were analyzed. It was concluded that ADH did not substantially affect thermal sweating in men.

Adult↗
PubMed1979

Chronopharmacokinetics of dipyridamole.

The experiment carried out in 6 volunteers shows a better availability of a 75 mg single oral dose of dipyridamole administered at 600 than at 2200. The availability of dipyridamole administered at 600. The dependence of kel and t0.5(elim) on the time of drug administration is less distinct.

Adult↗
PubMed1979

Time dependent changes in the pharmacokinetics of aspirin.

In an experiment carried out on six volunteers, measurement of total serum salicylate concentration was used to describe aspirin kinetics after a single 1500 mg oral dose. The availability of the drug was significantly better when it was administered at 6(00) than at 18(00) or 22(00). Also a significant time-dependence was found between the morning and evening values of both the serum half-life time of salicylate and kel. The possible relation between these results and the appearance of undesirable side effects in patients should be examined.

Adult↗