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Biomedical subjects

A Mashberg

Publications and source records attributed to A Mashberg.

At least 37 records · Page 2Linked to original sources
PubMed1980

Reevaluation of toluidine blue application as a diagnostic adjunct in the detection of asymptomatic oral squamous carcinoma: a continuing prospective study of oral cancer III.

This study was initiated to evaluate toluidine blue application as a worthwhile and simple diagnostic adjunct to clinical impressions. In an attempt to decrease false positives, a 10--14 day waiting period was initiated to allow inflammatory lesions to resolve before application of stain. Using toluidine blue applications with 235 prospectively documented persistent lesions (105 carcinomas and 130 nonmalignant lesions) resulted in a false negative rate (underdiagnosis) of 6.7% and false positive rate (overdiagnosis) of 8.5%. Using clinical criteria alone resulted in a false negative rate of 4.8% but with a tendency to overdiagnose--28.5% false positives. Combining both diagnostic modalities reduced the false negative rate to 1.9%, i.e., only two of the 105 cancers were not considered significant by toluidine blue stain or clinical impression. This staining technique appears to offer a feasible diagnostic "control" over the subjective impression of the clilnician. Persistent lesions that stain with toluidine blue should be considered carcinoma unless proven otherwise by biopsy.

Carcinoma, Squamous Cell↗
PubMed1980

Pre-auricular oat cell carcinoma metastases.

The oat cell tumor is a particularly lethal form of bronchogenic carcinoma. Cutaneous metastases occur occasionally in the pre-auricular area. In addition to benign and malignant parotid lesions, the differential diagnosis of a pre-auricular mass must now include metastatic disease, particularly if a history of a thoracic malignancy is elicited. We present two such cases of metastatic oat cell carcinoma in the pre-auricular region.

Aged↗
PubMed1979

Necrotizing sialometaplasia.

Three additional cases of necrotizing sialometaplasia are discussed. Clinical appearance of the lesion is not diagnostic. Microscopy shows pseudoepitheliomatous hyperplasia, squamous metaplasia, and acinar necrosis. No atypia is seen. Mucoepidermoid and squamous cell carcinoma are frequent wrong diagnoses. All reported lesions have healed without recurrence regardless of therapy.

Adult↗
PubMed1978

Erythroplasia: the earliest sign of asymptomatic oral cancer.

This prospective study was conducted to determine the significance of erythroplasia (red) versus leukoplakia (white) in the diagnosis of asymptomatic oral carcinoma and to accurately record the appearance of the erythroplastic lesion. Persistent asymptomatic lesions in any portion of the oral cavity, except the lip, that were considered clinically suspicious with our previous criteria (erythroplasia), or those changes that did not correspond to the visual criteria but were found in high risk sites, were studied and biopsies were performed. Degrees of redness versus whiteness and clinical diagnoses were documented. Of 148 lesions in 113 patients, 66 were malignant (52 invasive and 14 in situ). There was a false negative diagnostic rate of 4.5% (3 of 66) and a false positive rate of 7% (4 of 57). Of the malignant lesions, 86.3% were primarily red compared with 31.9% of the benign lesions. OF the cancers, 10.7% were predominantly white as opposed to 66.7% of benign lesions. This analysis confirms our previous suppositions that persistent erythroplasia rather than leukoplakia, in high-risk sites of the oral cavity, is the earliest and predominant sign of oral carcinoma.

Adult↗
PubMed1978

Malignant melanoma metastatic to the mandible.

Metastatic malignant melanoma to the jaws is uncommon and is usually accompanied by generalized involvement. Hematogenous dissemination with deposition and growth in areas of hematopoietic marrow (that is, the mandibular molar region) is the accepted mechanism for involvement of the jaw. Clinical and radiographic findings are nonspecific. Comprehensive history, physical examination, and tissue microscopy are essential to accurate diagnosis and management of the patient. Radiotherapy for palliation is the accepted mode of therapy for symptomatic metastatic melanoma. Prognosis in cases with secondary jaw involvement is grave. A case of malignant melanoma with metastases to the mandible is presented and the literature is reviewed.

Adult↗
PubMed1976

Anatomical site and size of 222 early asymptomatic oral squamous cell carcinomas: a continuing prospective study of oral cancer. II.

The site and size of 222 asymptomatic, primarily erythroplastic, cancers of the oral mucosa in 161 patients have been prospectively documented. Of 207 intraoral lesions (excluding 15 of the lip), 201 (97.1%) were found in three locations; floor of the mouth (101), ventral or lateral tongue (36), and soft palate complex (64). Of the 101 in the floor of the mouth, 73 occurred in the anterior portion with 33 involving the papilla at exit of Wharton's Duct (submaxillary gland). Of the cancers 84.2% were 2 cm or less and 41.9% were 1 cm or less. Of the lesions 2 cm or less 70.6% were invasive carcinoma. Minimal size does not preclude invasiveness. In view of the apparent predilection of oral carcinoma for particular sites (where there is no obvious agent), rather than random occurrence, the three aforementioned sites are designated as high risk areas which deserve particular scrutiny in an examination of the oral cavity. It is incumbent upon the clinician to biopsy all asymptomatic, persisten (14 days or more) mucosal aberrations in the high risk areas, especially those with erythroplastic components, regardless of size.

Carcinoma, Squamous Cell↗
PubMed1976

Mesenchymoma: a review of literature and report of two cases.

Both benign and malignant varieties of the mesenchymoma have been described. Previously reported cases of mesenchymoma in the head and neck are rare. Two cases of mesenchymoma occuring intraorally are reported here. In each case local excision has affected apparent cure, for periods of 12 yr and 8 mo, respectively. Local excision is advocated as the primary treatment for such lesions occurring in the oral cavity. Although recurrences in areas other than the oral cavity tend to undergo malignant changes, this phenomenon has bot been demonstrated in lesions occurring in oral tissues.

Aged↗