[Etiology and therapy of primary bacterial pneumonia in our practice].
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Biomedical subjects
Publications and source records attributed to A Misiewicz.
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Studies involved 69 men occupationally exposed--on average for 9-4 years--to manganese dusts and vapours at 0.00013 mg/l-0.00449 mg/l concentrations and trace amounts of ferrum and titanium. The control group consisted of 41 men unexposed to toxic substances. Those chronically exposed to manganese exhibited changes in serum albumins immunoelectrophoretic picture in form of much weaker saturation of IgA and IgM arches, transferrin and ceruloplasmin, and markedly increased saturation of IgG arches. Those changes may result from toxic effects of manganese upon liver cells.
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In those chronically exposed to air pollutants--i.e. a mixture of naphtha, tungsten, vanadium, titanium and cobalt--the following indices were calculated: number of erythrocytes and leukocytes, haemoglobin (Hb) level, colour index, hematocrit number, mean volume of erythrocyte (S.O.K.C.), mean weight (S.M.H.), and average haemoglobin concentration (S.S.H.) in erythrocyte, percentage composition of leukocytes. The results were compared with those of the control group. The test population exhibited: slightly decreased Hb level, decreased S.M.H. and S.S.H. in average erythrocyte. It is supposed that the decreased Hb concentration may result from the effect of naphtha on the haematopoietic system, disturbances in hemopoiesis under the effect of vanadium, as well as decreased siderofilin level.
Workers exposed to naphtha, tungsten, vanadium, cobalt and titanium exhibited decreased activity of asparagine and alanine aminotransferase, cholinesterase and ceruloplasmin in blood serum, as compared to controls. Activity of lactic acid dehydrogenase was not changed significantly. It might be surmised that absorption of metals and naphtha exhibits inhibitory properties in relation to the enzymes determined.
In those chronically exposed to manganese the activity of alanine aminotransferase (ALAT), asparagine aminotransferase (AspAT), lactate dehydrogenase (LDH), cholinesterase (ChE) and ceruloplasmin (CPL) was determined. As compared with the control group, only enzymatic activity was statistically decreased. Thus, determination of the mentioned enzymes in blood serum is of little value for evaluation of an early stage of manganese toxic effects.
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