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Biomedical subjects

A Mohnike

Publications and source records attributed to A Mohnike.

18 recordsLinked to original sources
PubMed1989

[THe effect of pregnancy on the long-term course of chronic glomerulonephritis].

During a long-term study in 34 out of 154 women with bioptically ascertained glomerulonephritis 38 pregnancies were observed. The clinical manifestation took place three times during and thirteen times immediately after the end of the pregnancy. Apart from membranoproliferative glomerulonephritides all morphological forms of glomerulonephritis were present. A nephrotic syndrome was existing in 14 women (41.2%). The patients with pregnancy after on an average 11.3 years observation time showed a stabile renal function in 85.3% in contrast to 71.9% of the other female patients (not significant). The pregnancy, including a nephrotic syndrome, does not deteriorate the long-term prognosis of the glomerulonephritis.

Biopsy↗
PubMed1988

Teratogenetic maternofoetal transmission and prevention of diabetes susceptibility.

Gestational diabetes and impaired glucose tolerance in pregnancy were found to be important teratogenetic risk factors for the development of diabetes in the offspring. Mechanisms of action and prevention of maternofetal transmission of teratogenetic susceptibility to diabetes are presented. Gestational diabetes induced in the F0 generation produced the following effects in the F1 and/or F2 generation: Early postnatal hyperinsulinaemia, decreased noradrenaline and serotonin and increased endorphin concentrations in specific brain regions, permanent hypoplasia of the hypothalamic ventromedial nuclei, decreased insulin responsiveness to glucose, impaired glucose tolerance and increased diabetes susceptibility.

Animals↗
PubMed1985

[Rational kidney diagnosis with special reference to noninvasive and invasive procedures].

The permanently growing demands on clinic and laboratory constrain to considerations concerning a rational diagnostics. The spectrum of clinical interrogations which needs a clarification by laboratory diagnostics increases continuously. For the nephrologic diagnostics is again oriented to a step programme, which is adapted to the centrally published references to the development of a comprehensive system of the renal dispensary. It takes into consideration the possibilities of the diagnostics of the specialist for general medicine up to the subspecialist in a county hospital. As to the invasive diagnostics, particularly the renal biopsy, one must be reversed. This is indicated then, when from the result consequences would arise concerning the therapy to be performed or the choice calling etc.

Biopsy↗
PubMed1985

High food supply in perinatal life appears to favour the development of insulin-treated diabetes mellitus (ITDM) in later life.

Men who were born in war and post-war periods with shortage of food supply (1943-47) showed a markedly low prevalence of insulin-treated diabetes mellitus (ITDM), but not of non-insulin-treated diabetes mellitus (NITDM) in later life. A significant increase (+54%) of ITDM prevalence was observed between 1976 and 1982 for subjects at 26-31 years of age, who were born in a post-war period (1945-50) with shortage and a peace period (1951-56) without shortage of food supply, respectively. By contrast, there was not found an increase--but even a slight decrease (-14%)--of ITDM prevalence between 1976 and 1982 for subjects at 38-43 years of age, who were born in a peace period (1933-38) without shortage and a war period (1939-44) with shortage of food supply, respectively. A similar clear dependence of diabetes prevalence on food supply in perinatal life could not be observed for NITDM. On the other hand, the prevalence of NITDM appeared to be significantly dependent--in contrast to ITDM--on food supply in adulthood.

Adult↗
PubMed1984

Further evidence for the dependence of diabetes prevalence on nutrition in perinatal life.

In order to investigate the possible influence of pre- and/or early postnatal nutrition on the development of diabetes mellitus in later life, diabetes prevalences were ascertained in subjects of similar ages who were born in different periods with or without shortage of food supply. Between 1974 and 1982 the total prevalence of diabetes mellitus increased in Berlin/GDR by 26%. A significantly higher increase of diabetes prevalence (approximately 90%) was found between 1974 and 1982 for subjects at 26-33 years of age, whose years of birth changed from a "hypocaloric war and post-war period (1941-1948)" to a "relatively hypercaloric peace period (1949-1956)". By contrast, there was not found any significant increase of diabetes prevalence between 1974 and 1982 for subjects at 34-41 years of age, whose years of birth changed from a "relatively hypercaloric period (1933-1940)" to a "hypocaloric period (1941-1948)". These findings give further evidence for the dependence of diabetes prevalence in later life on nutrition in perinatal life.

Adult↗
PubMed1980

[Haptoglobin types and chronic glomerulonephritis].

In 88 patients a chronic glomerulonephritis was diagnosed by histology and immunohistology. The haptoglobin type was also analyzed. The distribution of the haptoglobin types in the sample did not differ from the haptoglobin distribution in the population of Berlin. The distributions of histologic and immunohistologic forms of glomerulonephritis were related to the haptoglobin distribution in our patients. The distribution of histological subgroups does not depend on the distribution of the haptoglobins. In evaluation of the immunohistological subgroups we found that immunocomplexnephritis is less frequent in the group Hp 1--1 than in the groups 2--1 and 2--2. We suppose that persons with Hp 2--1 and Hp 2--2 are prone to increased antibody formation. Hp 1--1 is presumably a blocking antibody.

Antibody Formation↗
PubMed1975

On possible genetic and epigenetic modes of diabetes transmission.

1 In 4058 diabetics, an inverse relation (negative semilogarithmic correlation) was found between the age of onset and the familial aggregation of diabetes mellitus (P less than 0.01). Hence, juvenile (especially infantile) diabetes appears to be predominantly caused by genetic defects (mutations), whereas adult onset diabetes appears to be essentially based on epigenetic factors. 2. In 3890 diabetics with an onset age of more than 10 years, a highly significant predominance of familial diabetes aggregation was observed on the maternal side as compared to the paternal side (P less than 0.001). This finding suggests the possibility of an epigenetic ("teratogenetic") mode of diabetes transmission mediated by the mother.

Adolescent↗