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Biomedical subjects

A Nathanson

Publications and source records attributed to A Nathanson.

23 records · Page 2Linked to original sources
PubMedDate not supplied

Destruction and regeneration of jawbone after cryogenic application. An experimental study.

On 13 rabbits part of the lateral aspect of the jawbone was frozen with liquid nitrogen in two sessions. The animals were sacrificed 2, 4, 12 and 24 weeks after the cryosurgery. The specimens were analyzed with microangiography according to the Spalteholz technique and with light microscopy. The whole width of the lateral cortex, measuring around 3 mm, was subject to bone destruction two weeks after cryosurgery. New bone formation, on the other hand, was evident in the frozen area and on the undamaged periosteum some distance from the lesion. The same area, 12 weeks after the injury, was completely restored. Bone destruction and regeneration are discussed with special reference to the vascular response to the injury.

Animals↗
PubMedDate not supplied

Squamous cell carcinoma of the gingiva. Histological classification and grading of malignancy.

A histological classification and grading of malignancy has been performed on the initial biopsies from 124 patients with squamous-cell carcinoma of the gingiva treated during the period 1958-69 at the Karolinska hospital. Six different morphological parameters were evaluated with respect to the tumour cell population and the tumour-host relationship estimated in terms of a four-point scale. This permitted grading with total points ranging from 6-24. A strong correlation was found between the degree of histological malignancy and the fatal outcome of the disease. Thus a tumour with a point value of 16 almost always led to the death of the patient while the best results were achieved with surgery alone in the group of small cancers (T1 + T2) with low total malignancy points.

Adult↗
PubMedDate not supplied

The early vascularization of an autogenous bone inlay into an artificial defect in the rabbit mandibula.

The revascularization of two different autogenous bone grafts to an artificial defect in the rabbit mandibula was studied by means of microangiography, using Indian ink infusion into the carotid artery. The revascularization was compared between a longitudinally split autogenous humeral full thickness bone graft in 19 rabbits and autogenous full bone grafts from the iliac crest in 14 rabbits. The vascular pattern and ingrowth was followed at weekly intervals right to the end of the first month postoperatively. A progressive revascularization was found in both grafts investigated. The periosteum of the humeral graft was earlier and more completely revascularized than when an iliac graft was used. The penetration and downgrowth of capillaries were on the other hand more complete within the iliac graft. The vascular pattern is discussed with special reference to the osteogenesis in the bone grafts.

Angiography↗
PubMedDate not supplied

Effects of cryosurgery on the healing pattern of rabbit mandibular bone. A triple fluorochrome labelling study.

The reparative process of rabbit mandibular bone injured by cryosurgery was studied by a triple fluorochromic method. The regeneration started late, when compared with fracture healing, and reached its maximum some 4-8 weeks after cryosurgery. A normal distribution of fluorochromes was registered after l2 weeks. The regeneration occurred mainly through growth from the marrow cavity region where the cryogenic impact may have stimulated osteogenesis from surviving endosteum and bone marrow. The destroyed periosteum at the site of the probe-tip attachment did not regenerate, although new bone formation of periosteal origin was noticed at the border of the injured cortex. The general distribution of fluorochromes seemed to follow closely the autoradiographic image obtained using 99TcmMDP in a similar experiment, suggesting comparable ways of accumulation in bone tissue.

Animals↗