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Biomedical subjects

A Pacini

Publications and source records attributed to A Pacini.

At least 55 records · Page 3Linked to original sources
PubMed1977

[Proposal for the introduction of a new substance into hospital practice: dipropyl acetate sodium in the prevention and treatment of alcoholic delirium].

Reference is made to two years' work with the sodium salt of N-dipropylacetic acid in the prevention and treatment of alcoholic delirium tremens in 1500 subjects. The drug impeded the onset of the syndrome, or reduced its duration and gravity in cases where it was already present. It appeared suitable for the specific correction of the CNS functional changes responsible for delirium tremens.

Animals↗
PubMed1977

The role of sialic acid in determining the survival of circulating interferon.

Rabbit interferon has been extensively desialytated and its metabolic behaviour has been evaluated in the rabbit. The half-life of asialointerferon is significantly shorter than the native interferon and its urinary excretion becomes negligible. Moreover the rapid uptake of asialointerferon by the isolated and perfused rabbit liver, suggests a hitherto unsuspected catobolic pathway for this glycoprotein.

Animals↗
PubMed1977

Metabolism of interferon: hepatic clearance of native and desialylated interferon.

The effect of removal of sialic acid on the survival of rabbit serum and urinary interferon (IF) has been investigated in isolate, perfused rabbit liver preparations. In contrast with native IF, which may be already partially desialylated. IF freed of 80 to 90% of its sialic acid was rapidly cleared from the perfusate of normal livers, or livers pre-treated with actinomycin D. The results suggest that the mechanism of IF catabolism by the liver is similar to that reported for several other circulating glycoproteins.

Animals↗