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Biomedical subjects

A Panà

Publications and source records attributed to A Panà.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Effect of isoflavans and isoflavenes on the infection of Frp/3 cells by hepatitis A virus.

The effect of 6,4'-dichloroflavan and of isoflavan and isoflavene derivatives on hepatitis A virus (HAV) infection in a monkey cell line (Frp/3 cells) was studied. These compounds were not virucidal and had no measurable effect on the adsorption of virus to the cells at 0 degrees C, whereas they exerted an inhibitory effect on viral antigen synthesis when incubated with the infected cells during HAV multiplication. Among the substances tested, 6,4'-dichloroflavan and 6,4'-dichloroisoflavan showed the highest activity. These compounds are postulated to interact with an early stage (penetration and/or uncoating) of HAV infection.

Antiviral Agents↗
PubMedDate not supplied

Prions, prion diseases and decontamination.

Prions are extremely resistant to disinfection and sterilization methods used so far. The pathogenic prion protein core (called prion) consists of 142 amino-acids, is resistant to proteolytic enzymes, has a mass of 15 pikograms and is filtrable. Fixed by desiccation or chemicals may retain infectivity for years. It survives dry heat at 200 degrees C for 1-2 hours. Prions are fixed to stainless steel within minutes and remain infectious for long periods. Their pathogenetic properties depend on tertiary spatial structure (conformation) which is specific and transmissible in experiment. The prion decontamination appears by far the most important area of the prion science because very little, or nothing, has been done in the majority of world hospitals to prevent iatrogenic transmission. The number of potentially infectious patients is not known. Therefore, patients undergoing neurosurgery, laryngeal or ophthalmic operations, orthodental treatments and even anaesthetic or endoscopic applications should be classified into risk groups, even if clinically priondisease inapparent. The use (or misuse) of disposable instruments is certainly not the final answer for all cases and classic decontamination procedures, if possible because of the character of medical devices, appear still of greatest importance. We consider the high pathogen safety (HPS) autoclave from FEDEGARI as the best actual equipment for the effective decontamination of prions in the hospital practice. The investment costs are moderate and the handling is simple but must be careful. It appears practicable even in small specialized units.

Decontamination↗
PubMedDate not supplied

[The health services epidemiology in health agency: the initiatives, the activities, the structures. Introduction to the subject].

The subject which has been developed within the Workshop "the health services Epidemiology in health Agency: the initiatives, the activities, the structures. Direct and indirect evidences", held in Rome, in November 15th, 2001, is introduced and updated. After a historical excursus, the topical interest in the health services epidemiology, which has now assumed the aspect of a real, independent discipline, and the reasons for its development, are analysed. As an independent discipline, its typical methodology and function have to be recognised. The methodology is characterised by the wide use of qualitative methods, by the importance assigned to the secondary epidemiologic research (i.e. systematic reviews and meta-analysis) and by the particular interest devoted to evaluation rather than investigative surveys. The function is aimed at improving people's health by means of health care services and, as a practical consequence, useful to the former one, at improving the quality of health care services themselves.

Delivery of Health Care↗
PubMedDate not supplied

[Enteric viruses and bacteriological parameters in molluscs].

Eighty-seven samples of shellfish were collected considering: type of mollusc, origin, growing area, monitoring or for human purpose. The bacteriological parameters were: Fecal Coliforms, Escherichia coli, and Salmonella; whereas the virological parameters included: Hepatitis A and E virus, Rotavirus, Astrovirus and Enterovirus. In total, 63.2% of samples had normal bacteria values, only one sample was Salmonella positive. The percentage of positive samples for Hepatitis A virus was 5.7%, Rotavirus 29.9%, Astrovirus 27.6%, Enterovirus 10.3%. The recovery of hepatitis E virus was always negative, whereas 13 samples (14.9%) were positive for two viruses.

Animals↗
PubMedDate not supplied

[Presence of cytomegalovirus in maternal milk].

The AA. make in evidence the role of the milk as carrier of Cytomegalovirus. The virus was isolated in the 23.5% of the 17 specimens of milk examinated within the first 48 hours from the delivery. The contemporary observation of the urins of the womans was negative.

Adult↗
PubMedDate not supplied

HAV recovery from tap water: evaluation of different types of membranes.

A cytopathic strain of hepatitis A virus (HAV) has been used to evaluate the absorption-elution of several membranes. Filters were obtained from four different manufactures: Sartorius, Millipore, Gelman and Cuno. Only the electronegative HAWP (Millipore) and the electropositive (Cuno-Div.) filters appear to absorb HAV with a high efficiency.

Adsorption↗