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Biomedical subjects

A Panda

Publications and source records attributed to A Panda.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Role of aprotinin in the management of experimental fungal keratitis.

In an experimentally induced Aspergillus fumigatus fungal keratitis in 20 rabbits, aprotinin, an antiplasmin agent, was studied to find out its role as an adjuvant when given along with other established antifungal agents like natamycin and fluconazole. The 20 rabbits included in this study were randomly divided into four equal treatment groups. Once the ulcer was produced after intrastromal injection of 0.03 ml of A. fumigatus (5.5 x 10(4) spores/ml), different drugs/agents in combination were used in a randomized manner. These were natamycin (5%) + placebo, natamycin + aprotinin (40 IU/ml), fluconazole (0.3%) + placebo and fluconazole + aprotinin. The rabbits were followed up every day to note the signs of healing which included subsidence of corneal infiltration, disappearance of stromal abscess and subsidence of corneal oedema till complete healing. Results showed that the average healing time was 28.2, 28.4, 49.8 and 49.0 days for natamycin + placebo, natamycin + aprotinin, fluconazole + placebo and fluconazole + aprotinin, respectively. It suggests that aprotinin as an adjuvant has no definite role in the management of fungal keratitis. The plasminogen activator-plasmin system which is inhibited by aprotinin may not be the pathway through which filamentous fungi like A. fumigatus cause tissue destruction.

Animals↗
PubMedDate not supplied

Lamellar sclerokeratoplasty of epibulbar tumor in xeroderma pigmentosum.

A 10-year-old boy was followed up from the stage of biopsy-proven dysplastic conjunctival mass to carcinoma in situ. This carcinoma was managed by radical excision and lamellar sclerokeratoplasty. To our knowledge, this case represents the first reported successful management of conjunctival carcinoma in xeroderma pigmentosum.

Biopsy↗
PubMedDate not supplied

Ruptured globe 10 years after radial keratotomy.

PURPOSE: To report 3 cases (3 eyes) of globe rupture following blunt trauma 10 to 13 years after radial keratotomy. METHODS: Cases of traumatic ruptured globe after radial keratotomy were reviewed from a tertiary eye care center. One eye underwent therapeutic penetrating keratoplasty, the second was treated with a bandage contact lens, and the third developed retinal detachment leading to phthisis bulbi. RESULTS: Ruptured globes occurred through the keratotomy incision during activities of daily living (1 eye), assault (1 eye), and sports (1 eye). Two eyes regained a visual acuity of 20/30 or better; 1 eye was lost. CONCLUSION: Traumatic rupture of the cornea can occur more than 10 years after radial keratotomy.

Adult↗
PubMedDate not supplied

Massive corneal and conjunctival squamous cell carcinoma.

A patient with massive, protuberant squamous cell carcinoma of conjunctiva invading the whole cornea, so as to hang from the surface, was referred with a visual acuity of hand motion near to face. A microscopically-controlled, frozen section guided excision, followed by double-freeze-thaw cryoapplication to the sclera and the edges of the conjunctival bed and lamello-lamellar sclerokeratoplasty, was performed. Three years later the patient's visual acuity was 20/60 with no evidence of recurrence of the lesion. Frozen section guided excision with adjuvant cryotherapy and lamellar sclerokeratoplasty is a viable therapy for massive squamous cell carcinoma of cornea and conjunctiva.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Pattern of intraocular pressure changes following manual small incision cataract surgery.

OBJECTIVES: To find out the pattern of changes in intraocular pressure after manual small incision cataract surgery. METHODS: Consecutive patients (291 eyes of 291 patients) undergoing manual small incision cataract surgery were prospectively evaluated for change in IOP. Patients were further divided into two groups based on whether or not sutures were used to close the scleral tunnel. IOP was serially measured at day 1, 1st, 2nd, 4th, 6th, 8th and 12th week. RESULTS: The mean post operative IOP in eyes where sutures were not applied (12.59+/- 3.02 mmHg, 12.59+/-2.34mmHg, 12.54+/-2.19mmHg and 12.40+/-2.99 mm Hg at day1, 2week and 4weeks respectively) was lower than that where sutures were used to close the wound (15.57+/- 3.86mmHg, 14.05+/-2.52mmHg, 14.43+/-3.39mmHg at day1, 2weeks and 4 weeks respectively). There was a drop of IOP from the preoperative IOP in both suture (1.15+/-3.29mm Hg) and non suture (3.29+/-3.07mm Hg) group at 3 months of follow up. CONCLUSION: There is a small drop of IOP following sutureless MSICS during long term follow up. Eyes where sutures are applied are more likely to have higher IOP than those without sutures at the initial post operative period.

Cataract Extraction↗
PubMedDate not supplied

Keratoplasty and cataract extraction.

Fifty eyes were evaluated following penetrating keratoplasty and cataract extraction. Twenty five of them had intracapsular lens extraction while the remaining 25 had intercapsular method of extracapsular lens extraction. Both operative and post operative complications were more in group I. Visual outcome and graft clarity were also better in eyes of group II. Combined keratoplasty and intercapsular method of extracapsular lens extraction was recommended in eyes having both corneal and lenticular pathology.

Adult↗
PubMedDate not supplied

Corneal endothelial changes following pars plana lensectomy.

The corneal endothelial status was studied in 40 eyes of patients with congenital cataract before and 3 months after surgery. Twenty eyes of patients who underwent pars plana lensectomy revealed a mean endothelial cell loss of 8% (SD +/- .76) while the remaining 20 eyes which were operated by needling aspiration had a endothelial cell loss of 10% (SD +/- .89). The difference between the two groups was not statistically significant.

Cataract↗