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Biomedical subjects

A Pedersen

Publications and source records attributed to A Pedersen.

At least 91 records · Page 5Linked to original sources
PubMed1986

Diagnostic and prognostic implications of transient isolated negative T waves in suspected acute myocardial infarction.

The diagnostic and prognostic implications of transient isolated negative T waves were studied in 127 patients in whom acute myocardial infarction (AMI) was suspected. Eight-four patients with no AMI and no electrocardiographic changes served as the control group. The 2 groups were well matched. Twenty-nine patients (23%) with isolated negative T wave had a significant increase in serum creatine kinase (CK)-MB levels and fulfilled the diagnostic criteria for AMI. The increase in serum CK-MB levels did not predict a higher risk of hospital mortality, but during follow-up (median 31 months), a serum CK-MB level above 30 U/liter identified patients with a significantly increased risk of dying (p less than 0.05). Both the number of affected electrocardiographic leads and the sum of negative T-wave amplitudes were significantly related to the follow-up mortality rate (p less than 0.01). The comparison between control subjects and patients with negative T waves during follow-up showed more events among the patients: AMI (17% vs 8%, p less than 0.02); death (24% vs 12%, p less than 0.01); and AMI or death (31% vs 19%, p less than 0.01). Thus, only 25% of patients with aggravated chest pain and isolated negative T waves have AMI. However, the long-term prognosis for the entire group of patients with isolated negative T waves is poor, and any therapeutic intervention should be initiated immediately.

Adult↗
PubMed1986

In vitro interactions of murine peritoneal macrophages and sarcoma cells. I. Promotion of tumor cells proliferation by macrophages.

An ascites subline (AA) of the murine sarcoma MC1M grows in vivo in the peritoneal cavity but dies in vitro when cultured on glass or collagen. The viability of AA cells in vitro is not influenced in cocultures with fibroblast cell line L929, and is diminished in cocultures supplemented with macrophage culture supernatant or in cocultures with non-adherent peritoneal cells. However, AA cells proliferate in vitro on glass or collagen when cocultured with syngeneic, semisyngeneic, and allogeneic peritoneal macrophages. This was demonstrated by tritiated thymidine incorporation assay, by AA cell number counting, and by measuring AA cell protein content. Proliferation also occurs when AA cells are separated from the macrophage monolayer by millipore filters.

Animals↗
PubMed1985

Volumetric determination of extraoral swelling from stereophotographs. A method study in the buccal area.

A stereophotographic method for volumetric determination of the extraoral swelling after mandibular third molar removal is developed. The method error was 1.0 cm3. Compared to the size of the maximal swelling after removal of impacted wisdom teeth, this error is considerable. The technique can, however, be improved and furthermore applied to measurements of volume changes in other cranio-facial areas, as well as in other parts of the body.

Cheek↗
PubMed1985

Decadronphosphate in the relief of complaints after third molar surgery. A double-blind, controlled trial with bilateral oral surgery.

The purpose of the present double-blind study was to investigate the preventive effect of 4 mg dexamethasone (1 ml Decadronphosphate) on swelling, trismus and pain after removal of impacted mandibular third molars. The population comprised 30 healthy individuals (17 female, 13 male) who needed removal of 2 identical, impacted mandibular third molars. Each patient served as his own control as the teeth were removed in 2 sittings with either steroid or placebo injected into the masseter muscle just before starting the operation. Control visits took place 48 h and 7 days after the operations. The results showed that steroid administration led to about 50% reduction of postoperative swelling and trismus and to about 30% reduction of postoperative pain. No general or local complaints/complications occurred due to the steroid injection. It is concluded that prophylactic steroid treatment is effective in reducing postoperative complaints and that the administration is safe in the absence of contraindications for such administration. Prophylactic steroid treatment is therefore recommended in third molar surgery when pronounced postoperative reaction can be expected.

Adolescent↗
PubMed1985

Interrelation of complaints after removal of impacted mandibular third molars.

Swelling, pain and trismus were evaluated quantitatively after the removal of impacted mandibular third molars on 30 healthy individuals. Evaluation took place 48 h and 7 days after surgery. The mutual correlation between the complaints was determined as well as the correlation between the length of the operation and the degree of postoperative complaints. It is concluded from the study that the longer the operation takes, the more postoperative pain can be expected. However, neither swelling nor trismus is correlated with the length of time of the operation. The size of the swelling was not related to the degree of trismus or postoperative pain. A strong interrelation between postoperative pain and trismus indicates pain as the main reason for reduced mouth opening after removal of impacted mandibular third molars.

Acetaminophen↗
PubMed1984

Myocardial infarct size: correlation with cardiac arrhythmias and sudden death.

The study was made in order to determine the relationship between myocardial infarct size and the incidence of cardiac arrhythmias during acute myocardial infarction (AMI). In 317 consecutively admitted patients infarct size was estimated from serial serum CK-MB measurements. The ECG was continuously monitored during 18 days in hospital, and all electrocardiographic recordings were analysed daily. All patients were followed up one year after discharge. The median infarct size was larger among the 220 patients with arrhythmias than among the 97 patients without (814 Ul-1 vs 419 Ul-1, P less than 0.0001). There was a significant relationship between the estimated infarct size and the following arrhythmias: ventricular ectopic beats, sinus tachycardia, and atrioventricular block, whereas supraventricular ectopic beats showed no such relation. Patients with heart failure, however, had a high incidence of ventricular arrhythmias regardless of the size of their infarcts. The follow-up study demonstrated that the ventricular arrhythmias positively correlated with infarct size were also associated with significantly increased one-year mortality among hospital survivors. Thus, the present study indicates that not only pump failure, but also cardiac arrhythmias are connected with the negative influence of infarct size on prognosis.

Adult↗
PubMed1984

Glucocorticosteroids and oral medicine.

The article deals with the use of glucocorticosteroids in the treatment of the oral manifestations of Systemic Lupus Erythematosus (SLE), Discoid Lupus Erythematosus (DLE), Rheumatoid Arthritis (RA) in the temporomandibular joint, Pemphigus Vulgaris, Pemphigoid, Erythema Multiforme Exudativum (EME), Lichen Planus (LP), and Recurrent Aphthous Ulcerations (RAU). The benefit from steroids is discussed on the basis of current knowledge of etiology and pathogenesis of the various disorders. All of them are characterized by inflammation which appears secondary to a hypersensitivity reaction against autocomponents. Glucocorticoids do not interfere with the primary disease mechanisms. But it is concluded from the literature, that because of anti-inflammatory and immunosuppressive effects of the hormones, it seems reasonable to profit from steroids as palliatives in acute phases of the diseases and/or as long-term suppressors of the general host defense.

Arthritis, Rheumatoid↗
PubMed1983

Skeletal scintigraphy and radiography at onset of acute lymphocytic leukemia in children.

99mTechnetium skeletal scintigraphy performed at the time of diagnosis was compared with pain and radiographs in 24 children with acute lymphocytic leukemia. Localized intense uptake of the labeled compound in one or several metaphyses and increased uptake in diaphyses were typical findings by scintigraphy. The skeleton of each child was subdivided into 18 regions, and investigated for the presence of pain and for possible radiographic and scintigraphic abnormalities. In a total of 432 regions (18 regions in each of 24 children), pain was present in 23 regions, radiographic anomalies in 54 regions, and abnormal technetium uptake in 98 regions. Signs and symptoms were most often found in the lower extremities. Pain and radiographic or scintigraphic abnormalities were not regularly found in the same skeletal regions. The individual number of radiographic abnormalities was negatively correlated with age, whereas the number of regions with abnormal technetium uptake was positively correlated with age. No significant correlation was found between the number of abnormal scintigraphic or radiographic regions and the clinical outcome of the disease.

Adolescent↗
PubMed1983

Influence of acute myocardial infarct size on acute and one-year mortality.

In order to determine the prognostic effect of the size of an acute myocardial infarction (AMI), we prospectively studied a consecutive series of patients below 70 years of age, who had been admitted to the coronary care unit because of clinical suspicion of AMI. In 218 patients the diagnosis AMI was confirmed and the size of their infarcts was estimated from serum CK-MB measurements. In 102 patients the suspicion of fresh AMI was disproven, and they served as a control group. Both groups of patients were similar with regard to distribution of age, sex and coronary risk factors. During one year after discharge, all patients were observed with regard to death. The follow-up was 100% for the one-year observation period. The one-year survival was found to be much better in the patients without AMI on admission than among those with AMI (P less than 0.01). The infarct size was larger among those who died than in those who survived (P less than 0.01); mortality in hospital and within one year was closely associated with the estimated infarct size (P less than 0.01). However, the influence of infarct size on survival decreased with time. After six months there was no difference in the survival rate.

Aged↗
PubMed1983

The length of hospitalization after acute myocardial infarction determined by risk calculation.

The feasibility of the use of a Cox model for risk assessment of individualized hospital discharge after myocardial infarction was evaluated. First, a previously developed prognostic index computed at the fifth day after admission was tested on a new population of 1140 patients. It was confirmed that after 5 days half of the patients (52%) could be discharged with low risk. Second, a new competing risk variant of the Cox model that updates prognosis according to the occurrence of complications was developed that describes the risk of death, cardiac arrest, and cardiogenic shock within 44 days after hospital admission. With a risk of one of these events being below 2% during a 14 day period after proposed discharge, 453 patients of 966 survivors (47%) could be discharged after only 5 days. A longer stay (of up to 30 days) was proposed for 338 patients (35%) to achieve the same level of risk. The savings in hospitalization days would be 15%. These results were confirmed in a new sample of 197 patients from the same institution who were discharged according to the proposed system. Of the 169 day 5 survivors, 67% were discharged on days 6 through 15 and this resulted in only two unexpected deaths and a 20% savings in hospitalization days. We conclude that individually determined discharge time is feasible without increased risk of death of severe complications after early discharge.

Age Factors↗
PubMed1983

Effect of physical training on exercise hemodynamics in patients with stable coronary artery disease. The use of impedance cardiography.

Seventeen consecutive patients with stable coronary artery disease with a previous history of myocardial infarction were studied for evaluation of the effect of physical training on exercise hemodynamics. The patients were divided into two groups: Group A (n = 10), the control group and Group B (n = 7), the rehabilitated group. Patients in Group B had physical training for five months. The mean exercise time in Group B (trained group) was significantly greater than in Group A (17.0 +/- 3.3 vs 11.6 +/- 3.2, p less than 0.01). Cardiac output was measured by impedance cardiography. The resting hemodynamic parameters were not statistically different between the two groups. At sub-maximal levels of exercise, the blood pressure X heart rate product was the same in both groups. At maximal workload, the heart rate X blood pressure product was the same in both groups, while the cardiac output was significantly greater in Group B compared to Group A (16.0 +/- 5.7 vs 12.1 +/- 3.2 1/min, p less than 0.001). These results suggest that physical training may improve cardiac function during exercise.

Blood Pressure↗
PubMed1983

Hemodynamics in acute myocardial infarction the use of impedance cardiography.

Thirty-two consecutive patients with acute myocardial infarction (AMI) were studied during the first seven days following AMI. The stroke volume was measured by impedance cardiography. The patients were divided into two groups: Group A (n = 22), with clinically uncomplicated myocardial infarction and Group B (n = 10) with evidence of congestive failure, but not of pulmonary edema. Patients in Group B had predominantly anterior wall myocardial infarction compared to Group A (p less than 0.05). The heart rate was significantly greater in Group B compared to Group A (p = 0.0002). The systolic blood pressure, the mean blood pressure, stroke volume index, and left ventricular stroke work index were significantly lower (p less than 0.05) in Group B than Group A. Impedance cardiography can be easily applied to follow the course of the patients during the acute phase of myocardial infarction.

Adult↗