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Biomedical subjects

A Penttilä

Publications and source records attributed to A Penttilä.

At least 145 records · Page 8Linked to original sources
PubMed1975

Arteriosclerotic and other degenerative heart diseases in Finland. I. A death certificate study of the frequency of degenerative heart diseases among males and females.

All available information recorded on the death certificates of 12973 Finnish persons who, according to the official Finnish mortality statistics, died in 1968 from arteriosclerotic and other degenerative heart diseases (ADHD, rubrics 420-422 in ICD) comprised the material of the present study. The mortality of males from ADHD analysed by age and place of residence was very high when compared with various national rates of international WHO statistics. The degree of urbanization of the domicile did not have any statistically significant effect on the mortality from ADHD. Significant differences between various provinces were found in the mortality of males from ADHD. The male population living in the eastern provinces of Finland showed a highly significantly higher mortality from degenerative heart diseases than the male population living on the west coast. A highly significant difference was found in mortality between various subgroups of the Finnish male and female populations analysed by age, place of residence, and type of community. The uniform difference between the mortality of various male and female subgroups of the Finnish population, which was obtained using the present statistical survey of death certificates, and the fairly uniform distribution of high rate of mortality of males from degenerative heart diseases in most regions of the country lend further support to the reliability of cause-of-death statistics, since certification of deaths can then be regarded to occur uniformly and with about the same accuracy in different parts of the country.

Adult↗
PubMed1975

Arteriosclerotic and other degenerative heart diseases in Finland. II. A death certificate study of the examination of the cause of death from degenerative heart diseases.

A statistical survey of death certificates was made to analyse the ante-mortem and post-mortem medical and medico-legal examinations used in the determination of the cause of death of 12973 decedents who were recorded officially to have died of arteriosclerotic and other degenerative heart diseases in Finland in 1968. The relationship between the regional autopsy rate and the rate of mortality from degenerative heart diseases was studied in particular. The survey indicated that there was no systematic relationship between the type of ante-mortem and post-mortem cause-of-death examinations, including medical and medico-legal autopsies, and the rate of mortality from arteriosclerotic and other degenerative heart diseases in various groups of the Finnish population analysed by age, sex and domicile. This was concluded to be an indication of the reliability of Finnish cause-of-death statistics of degenerative heart diseases which show a generally high rate of mortality and prominent regional differences in the rate of deaths from those diseases among the Finnish male population.

Adult↗
PubMed1975

Effects of 400 R whole-body x-irradiation on 5-hydroxytryptamine content of the rat gastrointestinal tract.

The effects of a single 400 R whole-body dose of X-irradiation on the regional 5HT content of the gastrointestinal (G. I.) tract were studied from four hours to 40 days after irradiation. The total 5HT content of various G.I. tissues was determined and 5HT was also determined per unit of body weight, wet weight of tissue and tissue protein. Irradiation caused an immediate decrease of the amine content of various G.I. regions in adult rats. This was followed by recovery, the degree of which varied in different regions. Some minor morphological changes were seen in enterochromaffin cells one and two days after irradiation but not later. The effects of irradiation on the G.I. tissues were stronger in young rats, in whom no complete recovery of 5HT occurred within 45 days. The present results support the view that irradiation exerts a direct damaging effect on the gastrointestinal 5HT storage, which is associated with liberation of 5HT from amine-containing cells. The duration of the effect varies with age and intestinal segment concerned.

Age Factors↗