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A Polliack

Publications and source records attributed to A Polliack.

257 records · Page 15Linked to original sources
PubMedDate not supplied

Diffuse large cell non-Hodgkin's lymphoma: results of M-BACOD combination chemotherapy.

Twenty-seven adult patients with diffuse large cell lymphoma were treated with the M-BACOD regimen during the period 1980-86. Of these, 24 (89%) had advanced Stage III-IV disease by clinical staging and only 3 (11%) had limited disease. CR was achieved in 14 patients (52%), all of whom had advanced disease prior to therapy. The remaining 13 patients (48%) achieved only PR. Of the entire group of 27 patients, 11 (41%) died, 12 (44%) are still in CR, and 4 (15%) have relapsed and are still alive with PR. Of the 14 patients who achieved CR, 1 relapsed, but is currently in PR, showing minimal disease. All of these 14 patients are alive (11 months to 6 years post therapy), and 13 (93%) still remain in CR with a median time of CR of 45 months. Of the 13 patients who only achieved PR, 11 (85%) relapsed and died within a median time of 3.6 months, and 2 patients remain in PR. The above results are similar to those obtained in larger series recorded from other centers. In the light of improved results obtained with new regimens and ABMT, we have now adopted the MACOP-B regimen for treating aggressive lymphoma and have entered an ABMT program for patients with predictable poor prognostic features.

Adolescent↗
PubMedDate not supplied

Effects of retinoic acid and phorbol ester on lymphocytes and monocytes in B-lymphocytic leukemia.

PBMC concentrated from 12 patients with CLL were incubated for up to 6 days with various doses of TPA or RA in an attempt to induce differentiation. The results show a great heterogeneity in the cellular response to both inducers. TPA produced two major changes in B-CLL cells, namely the development of some hairy-cell leukemia features with an increase in Ig secretion and the expression of Leu M5 and TAC receptors. In contrast to TPA, RA induced only modest or no changes in surface, but increased numbers of large macrophages were seen as assessed by latex-bead ingestion, expression of Fc receptors and cytochemistry. These changes were more obvious after exposure to RA than to TPA. Thus, while TPA induces mostly differentiation and hairy-cell features in B-lymphocytes, RA induces activation of the monocyte pool with no obvious changes in the lymphocytic compartment.

Acid Phosphatase↗
PubMedDate not supplied

Bone marrow curettage in myelodysplastic disorders. A stimulus for regeneration in disturbed hematopoiesis.

Bilateral bone marrow curettage of the iliac crest was performed in eight patients with marked anemia resulting from various myelodysplastic syndromes. The procedure was performed with the idea that an element of faulty hematopoietic microenvironment existed and that regeneration of normal marrow might occur in areas distant from the site of curettage. Four of the eight failed to respond to this procedure and no long-term response was obtained. One of the "failed" patients had a delayed response 18 months after the curettage was performed. In four patients, the procedure proved to be successful and adequate hemoglobin levels were achieved (10 to 14 g/dL) with reduction of the blood transfusion requirement. The diseases of two of these patients are still in remission 26 to 96 months after the procedure was performed. The procedure is recommended for patients with anemia refractory to conventional therapy and in whom a faulty hematopoietic microenvironment may be present.

Aged↗