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Biomedical subjects

A Prier

Publications and source records attributed to A Prier.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Plasma exchange in rheumatology. Technical problems, tolerance, indications].

Plasma exchange, used since 1979 in the treatment of severe rheumatoid arthritis, has been the subject of numerous publications in the recent years. According to data from a review of the literature and from our personal experience, this therapy cannot be advocated in the usual forms of rheumatoid arthritis. Because of the side-effects, the complicated technical equipment required and the short duration of therapeutic results, plasma exchange should, for the time being, be restricted to malignant forms of rheumatoid arthritis, polyvisceral exacerbations in lupus and scleroderma, and hyperviscosity syndromes in globulinopathies.

Arthritis, Rheumatoid↗
PubMed1983

[Cauda equina syndrome and ankylosing spondylitis. Association with acromegaly. A myelographic and tomodensitometric study of the lumbar canal].

Cauda equina syndrome is a rare neurological complication of ankylosing spondylitis. The specific myelographic and tomodensitometric anomalies are exemplified by the reported observation. This case is unusual by the moderation of the neurological manifestations, and especially by the absence of sphincteral disorders. The characteristic roentgenologic signs of ankylosing spondylitis are associated with a scalloped appearance of the lumbar spinal column and antecedent quiescent acromegaly.

Acromegaly↗
PubMed1983

[Non-tuberculous abscesses of the psoas. A case of apparently primary abscess of the psoas due to Staphylococcus aureus].

Abscess of the psoas, which is a well recognized complication in tuberculous osteoarticular infections, can also occur in certain regional diseases of the bones or viscera: common germ osteitis, diverticulosis, colic cancer, appendicitis and, above all, Crohn disease. Abscess of the psoas can also present as an apparently primary pyogenic muscular infection. A case is reported of an abscess of the psoas due to Staphylococcus aureus, which occurred spontaneously in an apparently healthy 50-year-old woman, was cured by surgical drainage, and whose course confirmed its primary nature.

Abscess↗
PubMed1982

[Treatment of rheumatoid arthritis with pirprofen. Comparison of 2 dosage regimens].

One hundred ninety-five patients suffering from active rheumatoid arthritis were included in a two-week double blind multicentric study, whose purpose was to compare the efficacy and tolerance of a daily dose of 600 mg of pirprofen to that of 1200 mg and the placebo. The results show that there is a dose-effect relationship of definite clinical interest. Thus, the investigators judged the clinical results satisfactory in 60% of the patients in the 1200 mg group (400 mg t.i.d.) 44% of those in the 600 mg group and 36% of those on placebo. The difference is statistically significant (p less than 0.05). Side effects, primarily digestive, were noted in 34% of patients receiving 1200 mg/day, 15% of 600 mg/day and 32% placebo. 2 patients in the 1200 mg group interrupted their treatment for gastralgia and 1 patient on placebo for palpitations.

Adolescent↗
PubMed1982

[Hypophosphoremic osteomalacia of connective tissue tumors].

The authors undertake a general review of the association between hypophosphoraemia and connective tissue tumour, based upon three personal cases and 27 cases of benign connective tissue tumours, as well as cases of hypophosphoraemia related to malignant tumours or to diffuse dysplasia of connective tissue origin, collected from the literature. This syndrome is distinguished from hypophosphoraemia induced by other tumours (myeloma, carcinoma of the prostate) which are based upon different mechanisms. Hypophosphoraemia, associated with a fall in plasma levels of 1-25 (OH)2 D3 by inhibition of renal 1 alpha hydroxylase, suggests the existence of a complex tubular deficit. Removal of the tumour, most often vascular and intra- or para-osseous, results in rapid normalisation of laboratory then radiological and clinical abnormalities. The physiopathology of the syndrome remains very mysterious. It may be likened to certain tubulotoxic syndromes due to cadmium and in particular to maleic acid. However no precise data yet exists regarding any possible abnormal tumour secretion. In practice, any case of hypophosphoraemic osteomalacia requires investigation to locate a possible tumour of connective tissue, and this all the more so when it is accompanied by very low plasma levels of 1-25(OH)2 D2.

Adolescent↗
PubMed1982

[Absorption and metabolism of labelled vitamin D3 in elderly subjects].

This study involved three adult men and six elderly individuals (3 men and 3 women). Adult subjects served as the control group. All subjects were given one dose of 10 microCi of tritiated vitamin D3 (approximately 15 IU) per os. Blood samples were taken 5 min., 1 h, 2 h, 3 h, 4 h, 6 h, 8 h, 24 h, 48 h, 72 h, 96 h, 120 h, 144 h, 168 h and 192 h after administration of vitamin D3. The concentrations of tritiated vitamin D3 and 25-hydroxyvitamin D3, its principal metabolite, were measured in each sample after extraction and purification by high performance liquid chromatography (HPLC). In addition, two adult subjects and three elderly women subjects were given an identical dose of tritiated vitamin D3 approximately 10 days following the end of the initial experience. Blood samples were collected at the times indicated above and analyzed in identical fashion. The percentage of intestinal absorption of vitamin D3 and the amount of vitamin D3 metabolized to 25-hydroxyvitamin D3 were calculated as were the time constants for vitamin D3 and 25-hydroxyvitamin D3 disappearance curves. Review of these parameters confirmed that significant individual variations exist for intestinal absorption of vitamin D3. Study results did not furnish any evidence of a decrease in 25-hydroxylation of vitamin D3, nor any increase in the rate of disappearance of vitamin D3 or 25-hydroxyvitamin D3 which might explain the very low levels of 25-hydroxyvitamin D3, often found in aged persons.

Administration, Oral↗
PubMed1982

[Treatment of severe or vasculitis associated forms of rheumatoid arthritis by plasma exchanges (author's transl)].

Five patients with typical seropositive rheumatoid arthritis were treated by plasma exchange. All patients had severe affections resistant to conventional treatment, while in four cases the disease involved extra-articular localizations: rheumatoid nodules (3 cases), polyneuritis (1 case), skin necrosis (1 case). Each patient received between 5 and 10 plasma exchanges over a period of 3 to 4 weeks. No major complications were observed. Immediate results were very good in all cases, as shown by absence of clinical expression of the arthritis, marked regression in extra-articular symptoms, and reduction in erythrocyte sedimentation rate without parallel alterations in rheumatoid factor levels. Improvement lasted for only a few weeks in 3 patients, in one case preceded by an acutely painful episode. In the remaining 2 cases, with associated vasculitis, improvement has been sustained for a period that now exceeds one year. Results are compared with those reported in the published literature, and the mode of action and indications for plasma exchange in rheumatoid arthritis discussed.

Adult↗
PubMed1981

[Systemic mastocytosis with myo-pericardial localization and atrioventricular block].

The case of a 46 year old man with systemic mastocytosis with myocardial and pericardial involvement confirmed histologically after open biopsy is reported. The patient presented with skin, bone and medullary lesions and, in addition, with atrioventricular block and pericardial effusion. The possible mechanisms of the atrioventricular conduction defect are examined in the light of the physiological role of the mastocyte and research into the action of histamine on the myocardium. In particular, the negative dromotropic effect of histamine and fibrosis formation related to the mastocyte's function of connective tissue regeneration are discussed. This case, though rare, should alert the clinician to the possibility of myocardial and pericardial involvement in patients with mastocytosis. Further study into the effects of histamine on myocardium under physiological and pathological conditions is required.

Cardiomyopathies↗
PubMed1980

[Occupational systemic lupus due to cosmetics (author's transl)].

A hairdresser with lupus erythematosus noted that acute attacks of his illness always coincided with periods of intense occupational activity. The lupus presented all the biological characteristics of an induced affection, but the patient was not taking medication. The disorder disappeared completely after a period of 4 years, following a change of occupation. The role of aromatic coloring agents is discussed.

Aniline Compounds↗
PubMed1980

[Hypophosphoremic osteomalacia secondary to benign connective tissue tumors: a report on three unusual cases with vitamin D metabolites measurements (author's transl)].

Three cases of benign connective tissue tumors (intracranial frontal hemangiopericytoma, rectosigmoid hemangioma, intraspinal neurinoma) associated with hypophosphoremic osteomalacia and reduction in plasma 1-25 (OH)2D levels are described. Rapid reversal of biological anomalies and subsequent recovery from clinical manifestations were observed after tumor ablation. Twenty-two identical cases have been reported in the published literature. The sharp- fall in 1-25 (OH)2D levels without secondary hypocalcemia or hyperparathyroidism suggests that intestinal absorption of calcium is not entirely dependent on this metabolite. Increased phosphoremia without a parallel rise in 1-25 (OH)2D levels was noted in one case. The possibility of an existing connective tissue tumor should be explored in all cases of hypophosphoremic osteomalacia.

Adult↗
PubMed1979

[Physiopathology of osteoporosis (author's transl)].

Osteoporosis is the result of the progressive loss of bone substance which occurs during a lifetime. Its histomorphological characteristics have been well-defined and it appears to be a single entity more particularly related to the general problem of cellular senescence. The rate at which bone is lost can be influenced by many events or general factors, known or unknown, which are capable of accelerating or slowing down its progression. The period when the fracture threshold is passed appears to depend on a bone mass which is weak at the end of the growth period, followed by genetic, mechanical--related more specifically to insufficient muscular activity--, hormonal-hypo-oestrogenemia-factors, and pathological episodes of more rapid demineralization (immobilization, corticotherapy) which become more irreversible with advancing age.

Adrenal Cortex Hormones↗
PubMed1979

[Mastocyte osteoporosis].

We present five cases of severe osteoporosis accompanied by a skin and/or bone mastocytosis. The rarity of mastocytosis demonstrates that these cases are not the result of simple coincidence, especially since none of them involves other general of phospho-calcium anomalies that could explain the demineralization. The latter is accompanied by a high level of histaminemia or histaminuria, a non-specific anomaly. Mastocyte osteoporosis involves a great many unknown factors on the physiopathological level, but in practice it is necessary to look for a mastocytosis when confronted with a severe osteoporosis that appears to be primary. Cytostatic treatment (chlorambucil, cyclophosphamide) seems capable of improving the evolution of the bone disease.

Adult↗
PubMed1979

[Radiocompetitive dosage of 25 hydroxyvitamin D and 24, 25-dihydroxyvitamin D in geriatrics. Study of seasonal variations].

Dosages of 25 (OH) D and of 24, 25 (OH) 2 D in the plasma were done in March and October in 26 women more than 70 years old, hospitalized in a semi-chronic disease hospital of the Paris area. Eleven young adults, studied in June, served as control. There was a significant decrease of 25 (OH) D and 24,25 (OH) 2 D in older individuals (pL 0,001). In march, the levels of 25 (OH) D and 24,25 (OH) 2 D were respectively 2,7 +/- 1,6 mg/ml and 0,88 +/- 0,53 mg/ml. In October the level of 25 (OH) D (5,8 +/- 2,6 mg/ml) were significantly higher (p L 0,01) whereas the level of 24,25 (OH) 2 D did not vary (0,84 +/- 0,58 mg/ml). These results are in agreement with those obtained in England. The underline the relative deficit vitamin D in older individuals. The constant decrease of 24, 25 (OH) 2 D remained unexplained.

Aged↗