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Biomedical subjects

A Prier

Publications and source records attributed to A Prier.

At least 73 records · Page 4Linked to original sources
PubMed1978

[Pyrithioxine a new basic treatment of rheumatoid polyarthritis: initial study of 72 cases with a 6-month follow-up].

Pyrithioxine has certain chemical resemblances to penicillamine and is used as original treatment in a series of 72 cases of rheumatoid arthritis over a period of six months in a dose of 600 mgs daily. Results were favourable in 63% of cases with important lowering of the articular index, return to normal of the sedimentation rate and less frequently a reversal of the Waaler-Rose reaction. Secondary complications were essentially muco-cutaneous, sometimes gastric and necessitated stopping treatment in 15% of cases. No other serious side effect has been observed. When compared with penicillamine pyrithioxine would appear less efficacious but better tolerated. The usefulness of this new medicament in the treatment of rheumatoid arthritis needs to be further explored.

Adult↗
PubMed1977

[Pyrithioxine: a new basic treatment of rheumatoid arthritis. Open study of 60 cases with a follow-up of 6 months].

Pyrithioxine, a chemical compound with several points in common with penicillinamine, was used for six months as the basic treatment in a series of 60 cases of rheumatoid arthritis, in a dose of 600 mg per day. The results were favourable in 60 per cent of cases, with a marked fall in articular index, a return to normal of sedimentation rate and, less commonly, negativisation of the Rose-Waaler reaction. Side effects were essentially cutaneo-mucosal (pruitus, rash) and necessitated the interruption of treatment in 16.5 per cent of cases. No complications were seen. Compared with penicillinamine, pyrithioxine appears to be less effective but better tolerated. The place of this new basic drug in the basic treatment of rheumatoid arthritis remains to be precisely determined.

Adult↗
PubMed1977

[Study of optimal posology of penicillamine in the treatment of common rheumatoid polyarthritis (apropos of a personal series of 200 cases)].

A comparison of two series of patients with rhe,matic polyarthritis, the one (n = 140) treated with dosage equal to or higher than 900 mg, the other (n = 60) with dosage between 600 and 750 mg, did not reveal significant difference in clinical and biological efficacy. The number of side-effects was not significantly reduced by lower dosage, except for digestive tract disorders. A reduction of dosage does, therefore, not permit less strict supervision and monitoring for side-effects of treatment.

Arthritis, Rheumatoid↗
PubMed1976

[Hyperparathyroidism caused by a juxtacardiac adenoma].

The authors present a case of parathyroid adenoma in the sinus of Theile, and in this connection review the deep mediastinal localisations of these "secret" adenomas, inaccessible to the classical pre-operative investigations.

Adenoma↗
PubMed1976

[New cases of familial generalized cortical hyperostosis with dominant transmission (Worth's type) (author's transl)].

A case of two families with a total of 5 cases of generalized cortical hyperostosis of the cortex of the long bones is clinically latent. It is not accompanied by any osseous fragility and is usually discovered by chance. Mandibular hypertrophy can occur but is not constant. It must be differentiated from the recessive form described by Van Buchen, which is more severe and involves extensive and progressive osteocondensation which can lead to paralysis of the cranial nerves. The small number of cases published (23) leads one to suppose that its diagnosis is frequently missed, undoubtedly because it is mixed up with a minor form of osteopetrosis.

Adult↗
PubMedDate not supplied

Pyrithioxine and thiopronine: new penicillamine-like drugs in rheumatoid arthritis.

Two new SH-CH3-containing drugs have been studied as penicillamine-like agents. Pyrithioxine--retrospectively compared to a D-penicillamine series--was associated with fewer side effect-related withdrawals (14 vs 39) but with more non-responses and withdrawals for relapse. A review of the literature shows that thiopronine and D-penicillamine have a similar "score" of side effects and good responses. More extensively-controlled trials are needed for a better assessment of these new drugs.

Adult↗
PubMedDate not supplied

[Study of 70 cases of rheumatoid polyarthritis treated by pyrithioxin with a 1-year follow-up].

The authors present their own series of 70 rheumatoidpolyarthritis cases treated with pyrithioxine during one year or more except in the case of failure or intolerance. The following results were observed after one year: 54 percent showed positive results, 34 percent showed no results or dubious ones, and there was 13 percent of discontinuance because of intolerance. Modifications of the posology and methods of administering are proposed, and the role of pyrithioxine, as a basic treatment for rheumatoid polyarthritis, is discussed.

Adult↗