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A Prier

Publications and source records attributed to A Prier.

77 records · Page 5Linked to original sources

[Various agents influencing lymphocyte chromosome aberrations observed in inflammatory diseases of connective tissue].

From chromosome breaks observed in lymphocyte culture of patients with auto-immune diseases, the authors study the factors favouring the onset of these breaks, (clastogenic factor and superoxide radicle) and those which appear able to reduce them (D-penicillamine and dismutase superoxide). The therapeutic implications of these findings will be the object of later publications.

Animals↗

[Superoxide dismutase and rheumatoid arthritis. Study of a series of 6 cases].

The authors present a short series (6 cases) of serum positive rheumatoid arthritis, treated by I.M. injections (5 cases) or intra-articular injections (one case) of dismutase superoxide of bovine origin. The treatment was stopped in one case for local intolerance. Four cases treated for four months by the intramuscular route, were uninfluenced by the treatment, nor was the patient treated by the intra-articular route. The laboratory parameters (E.S.E., Rose Waaler reaction) were not modified. On the other hand, the lymphocyte fragility in culture was improved. The good tolerance of this compound in the laboratory will permit further trials in higher dosage.

Adult↗

Multidisciplinary day hospital treatment of rheumatoid arthritis patients. Evaluation after two years.

The availability of multidisciplinary care for rheumatoid arthritis is still limited. The Raoul Dufy Program offered by the Saint-Antoine Teaching Hospital in Paris provides one-on-one personalized care in a day hospital setting as an adjunct to conventional medical follow-up. Listening and providing information and education are major objectives of the nurse, rheumatologist and physical therapist participating in the program. The team also includes a social worker, a surgeon, a dietician, a podiatrist and a psychologist, who intervene as needed. Seventy patients attended the program between December 1993 and September 1995 and were asked to complete a baseline and a three-month questionnaire designed to evaluate the effects of the program in terms of new therapeutic interventions, patient knowledge and quality of life. The patient knowledge score increased significantly (P < 0.0001). Many therapeutic interventions were initiated after program attendance, especially in the fields of podiatry, psychology and physical therapy. However, the quality of life score failed to improve. These results and the substantial patient demand for appointments are encouraging. Further work is needed on the methodology of multidisciplinary care evaluation. Coping strategy evaluation tools may allow to identify some of the specific benefits provided by the multidisciplinary approach.

Adult↗

Multiple stress fractures in a scleroderma patient on methotrexate therapy.

A patient on methotrexate therapy for scleroderma developed four stress fractures within a period of 13 months. She was not on steroid therapy and had no risk factors for osteoporosis. A review of the literature found 13 cases of stress fractures under methotrexate therapy. Whether methotrexate can induce bone changes remains controversial.

Female↗