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Biomedical subjects

A Réffy

Publications and source records attributed to A Réffy.

At least 19 recordsLinked to original sources
PubMed1990

Pathological alterations in human tendons.

The present authors analyzed the pathological alterations of 1966 tendons examined in the National Institute of Traumatology, Budapest, during the past 18 years. The majority of cases proved to be tendinopathies (hypoxic-degenerative tendinopathy or calcific tendinitis, tendolipomatosis and mucoid degeneration) leading to tendon rupture. The incidence of tendon tumors, foreign bodies, infectious tendon diseases, and other pathological conditions was clearly lower. The methods of tissue preparation and of examination of tendon specimens were also evaluated. Light microscopy was sufficient for the diagnosis of pyogenic tendinitis, tumors, xanthoma, gout, and gangrene. In degenerative tendinopathies and alterations due to hereditary disease, electron microscopy was necessary. Polarization microscopy had a key role in examination of collagen structure and architecture, and identification of foreign bodies in the tendons. Enzyme histochemical and immunohistochemical examination were reliable but not absolutely necessary in the diagnosis of tendon pathology.

Academies and Institutes↗
PubMed1990

[Recurrent infantile digital fibromatosis].

In connection with a boy's case, receiving treatment in their institute several times, authors sum up our knowledge on infantile relapsing digital fibromatosis, first time in Hungary. Results of histological and electronmicroscopic examination are reported compared to results of foreign authors' studies of similar subject.

Amputation, Surgical↗
PubMed1989

[Immunohistochemical and immunologic changes in aponeurosis in Dupuytren's disease].

Authors examined the aponeurosis of 23 patients with Dupuytren's contracture and of 5, formerly healthy persons, who died in consequence of accidents. It was found that the IgA and IgM content of the palmar aponeurosis is significantly elevated in Dupuytren's disease. The distribution of the immunglobulin containing cells and the fibronection localisation of the aponeurosis was also examined. On the basis of their examinations they think that the autoimmun mechanism may have a role in the development of Dupuytren's disease.

Dupuytren Contracture↗
PubMed1989

Quantitative alterations of intramuscular connective tissue in calf muscles of the rat during combined hypoxia and hypokinesia.

The investigations were designed to study the long-term effect of hypoxia, hypokinesia and of combined hypokinesia and hypoxia on the skeletal muscle in the rat. In the muscles of the hypoxic and hypokinetic animals serious degenerative changes were found and the fibre-type ratio was altered. In the hypoxic animals moderate fibrosis was revealed. In the hypokinetic, and hypokinetic + hypoxic animals the amount of connective tissue was 5 to 10-fold greater in the calf muscles as compared to the control.

Adenosine Triphosphatases↗
PubMed1989

Glycogen-enzymes containing bodies in type 2 fibres of tenotomized muscles in the rat.

Inclusion bodies containing glycogen-enzymes were found in 30 to 60% of type 2 fibres of tenotomized calf muscles (m. gastrocnemius, m. soleus, m. plantaris) in rats, using histochemical reactions. The bodies appeared within 1 week after the tenotomy and were localized both in the central and the subsarcolemmal regions and rarely extruded into the extracellular space. These aggregates are 3 to 15 microns in length and 2 to 11 microns in diameter. In addition to glycogen, these bodies also contained various enzymes of the glycogen metabolism such as phosphorylase, a branching enzyme, and glucose-6-phosphatase, but showed no NADH-reductase, lactate dehydrogenase, or myofibrillar ATP-ase activity. The results indicate that glycogen-enzymes containing bodies are a degenerative phenomenon, which occurs only in type 2 fibres of the tenotomized muscles.

1,4-alpha-Glucan Branching Enzyme↗
PubMed1988

Cortical and trabecular osteopenia after immobilization. A quantitative histological study of the rat knee.

The aim of this investigation was to examine the effect of short-term immobilization on subchondral cortical and trabecular bone tissue in the rat tibia and to determine whether there was any difference when the knee was immobilized in extension or flexion. Thirty-six male rats were used in this study, and in 18 the knee was fixed in extension and in 18 in flexion. The time of immobilization was for 1, 2 and 3 weeks, with 12 animals in each group and 6 knees in extension and 6 in flexion. The following parameters were measured: (1) the mean thickness of subchondral and both periosteal cortices; (2) cortical porosity; (3) trabecular bone volume; (4) relative osteoid volume, and (5) relative osteoid surface. The mean cortical thickness decreased during the period of immobilization and the cortical porosity significantly increased. The trabecular bone volume was unaltered in the first week, but after 3 weeks it had decreased. The relative osteoid volume decreased significantly during the three weeks, and the relative osteoid surface moderately increased. No relationship was found between the quantitative osteopenic alteration of subchondral bone and the position of immobilization.

Animals↗
PubMed1988

Immunopathological study on palmar aponeurosis in Dupuytren's disease.

The authors examined the immunological and immunohistochemical alterations of palmar aponeurosis in Dupuytren's contracture. In the IgG-content no difference were found between the intact and diseased aponeurosis. The mean of IgA content was 2 fold, the IgM content 3 fold higher in Dupuytren's aponeurosis than in normal ones. The immunoglobulin containing cells localised around the Dupuytren's nodules and in fibrotic, but not nodular parts of aponeurosis. Extracellular immunoglobulin deposits were not found.

Adult↗
PubMed1988

Fine structural alterations of the palmar aponeurosis in Dupuytren's contracture. A combined scanning and transmission electronmicroscopic examination.

The authors examined the fine structural alterations of palmar aponeurosis in Dupuytren's contracture. Two types of the fibroblasts can be identified: classic fibroblasts and myofibroblasts. In the Dupuytren's tissue one fourth of all non-inflammatory cells were regarded as myofibroblasts. In the Dupuytren's aponeurosis the orientation of the thin and thick collagen fibers varied. The Paccini corpuscles were hypertrophised and around them compact collagen tissue was increased.

Adipose Tissue↗
PubMed1987

Fine structural changes in the articular cartilage of the rat's knee following short-term immobilisation in various positions: a scanning electron microscopical study.

The knee joints of 36 rats were immobilised in a padded plaster cast (18 in the flexed and 18 in the extended position) for 1, 2 and 3 weeks. The femoral articular cartilage was then examined under the scanning electron microscope. After 1 week's immobilisation in the flexed position, the surface layer of the cartilage showed disruption and the superficial chondrocytes were necrotic. The sites of the necrotic chondrocytes were seen as pits on the cartilage surface. In the animals whose knees were immobilised in the extended position, the changes were not so great in severity or extent. After 2 weeks, more advanced changes could be detected in both groups, but they were more severe in the flexed group. After 3 weeks the changes in articular cartilage were diffuse in the flexed, but focal in the extended group. Diffuse necrosis of chondrocytes, with pit formation on the surface and disruption and disintegration of the collagen fibres, was seen to some extent in all the animals. In the flexed group the changes extended to the whole weightbearing surface of the articular cartilage of the femur, except the intercondylar sulcus. In the extended group, a superficial fibre network was found without the formation of closely packed collagen fibre bundles, and the changes in the chondrocytes were seen only in localised zones. The authors suggest that during immobilisation, especially in the flexed position, articular hypoxia occurs due to a decreased amount of synovial fluid, the increased compression of the cartilage surfaces and the increased intra-articular pressure. This causes degeneration and necrosis of the superficial chondrocytes and the superficial cartilage layer.

Animals↗
PubMed1987

Regeneration of human tendons after homologous tendon-graft transplantation. A morphological study of 25 cases.

The authors examined the regeneration and incorporation of homologous tendon grafts in 25 patients from 10 days to 20 years after tendon grafting. Newly formed collagen fibers in the place of graft are first observed 3 months after transplantation. The reorganization of tendon grafts begins at the end of the first postoperative year and is accomplished within the second year.

Adolescent↗