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Biomedical subjects

A Rodríguez

Publications and source records attributed to A Rodríguez.

At least 289 records · Page 16Linked to original sources
PubMed1984

[Zinc and copper levels in Chilean infants].

Zinc and copper levels were determined by atomic absorption spectrophotometry, in the hair and plasma of 81 Chilean infants of both sexes, comprised within an age range of two to 36 months, after routine clinical examination at a Peripheral Health Service. The children were eutrophic, free from chronic pathologies, and their birth weights were over 2,500 grams. The infants were distributed within seven age groups and the mineral levels found were correlated mainly with age and sex.

Age Factors↗
PubMed1983

Crystals of polyglycine in the beta form.

Well-defined lamellar crystals of polyglycine I (the beta modification of polyglycine) have been grown from a solution of a sample of 5000 molecular weight. The crystals are elongated and have an average thickness of 40 to 50 A. The unit cell is monoclinic and the crystals have a twined structure. Electron diffraction reveals that the polypeptide chains are normal to the basal plane of the crystals and that the hydrogen bonds are parallel to their long sides. From these data we conclude that crystals of polyglycine I have a folded beta structure.

Crystallization↗
PubMed1983

Family studies of the HLA system in acute post-streptococcal glomerulonephritis.

Eighteen families (67 siblings) of index cases with acute post-streptococcal glomerulonephritis (APSGN) were typed for HLA-A,B,C,DR antigens. Twenty cases of clinical nephritis and 10 cases of asymptomatic disease with detected among the sibships. In eight families with more than one affected individual comprising 18 sib pairs random segregation of paternal and maternal HLA haplotypes was found (0.5 less than p less than 0.06), but some antigens (CW1, DR3) showed deviation from the expected 1:1 ratio in affected and nonaffected siblings in backcross families. We had previously noticed the existence of Mendelian recessive ratios in APSGN but in the absence of clear evidence for a dominant or recessive mode of inheritance for a putative APSGN susceptibility gene(s), pedigree data were analyzed twice for linkage with HLA using the two genetic models. The data obtained, although not sufficient to reject the hypothesis of linkage, provide no support for it. Comparison of the frequency of 61 HLA antigens among 42 unrelated APSGN patients and 109 controls, showed that HLA-DRW4 is more frequent among the former (pc = 0.0500).

Acute Disease↗
PubMed1983

[Subcutaneous fat necrosis of the newborn infant. Apropos of 2 cases].

Two cases of subcutaneous fat necrosis of the newborn are reported, an infrequent disease characterized by nodules or cutaneous endurated plaques that appears a few days after birth, which histopathologic studies shows fat necrosis with formation of giant cells granulomas strange body type and the presence of needle shaped clefts corresponding to fat crystals. This is a benign disease that has to be to differentiated from sclerema neonatorum, a serious entity which coexists with another disease so we also think it could be more a symptom than an authentic thickness. The two entities are vinculated physiopathologically by the injury of the fat tissue with a minor quantity of oleic acid and a major relative proportion of palmitic and stearic acid; than that of the adult, which conditions its easy solidification.

Fat Necrosis↗
PubMed1982

Some variables of the craniofacial complex in a Venezuelan population of Negroid ancestry.

A total of 226 individuals (101 males and 125 females), from La Sabana, a Venezuelan Negroid isolate, with ages between 8 and 60 years, were studied in order to characterize the population for its craniofacial variables and to study the behavior of these variables in relation to age and sex. The variables studied were grouped in three categories: direct cephalometric variables, which included 6 measurements taken directly on the individuals; indirect cephalometric variables, which included 18 measurements (9 angular and 9 linear), taken on lateral head films; and dental variables, which included 9 measurements taken from dental models. In general the direct variables showed the lowest coefficients of variation (CV), suggesting homogeneity within this sample. They were followed by the dental and the indirect variables, which had the highest CV values. In order to detect age and sex effects on the variables, sex and age group comparisons were performed with Student t tests. A greater proportion of significant differences were found among the direct variables, indicating that age and sex have more influence on this group of variables than upon the other two. Comparisons of our sample from La Sabana, with samples from African Negroid, Caucasoid, and Amerindian population show that La Sabana individuals have a craniofacial pattern basically Negroid, as we expected, although some contribution from Caucasoides and especially Amerindians is also suggested in our data.

Adolescent↗
PubMed1982

[Rapid visualization and separation of serum lipoproteins of the rat by ultracentrifugation in saline density gradients].

A method is presented for the visualization and location of lipoprotein bands in density gradient ultracentrifugation. A 3 hour spin results in a good separation of the major rat serum lipoprotein classes: very low, low and high density lipoproteins, by using small centrifuge tubes and highspeed rotors. In addition, the concentration of cholesterol, triglyceride, phospholipid and protein in the lipoprotein fractions obtained by this technique was also determined.

Animals↗
PubMed1982

Evaluation of short stature in children.

Within a year 429 children referred for short stature have been evaluated. The age at consultation ranged from 5 months to 17 1/2 years. Healthy but small children came at 5 to 7 and 10 to 13 years, while those with different pathologies attended the clinic at all ages. The stature of 43% of the investigated children ranged within normal limits (till -2 SDS), while 57% had a small stature. 68% of the children could be considered healthy, 32% had different endocrine and nonendocrine diseases responsible for their growth retardation. Retarded bone age (greater than 2 SD below the mean) was observed in 65% of the significantly short but otherwise healthy children and in only 28% of the healthy children with heights above -2 SD. Extreme short stature was mainly associated with a recognized disease of chronic and genetic origin, low birthweight and malnutrition. The high incidence of hypopituitarism (15 patients) is due to the fact that this study was performed in an endocrine clinic.

Adolescent↗
PubMed1981

Experimental endocarditis caused by Streptococcus sanguis: single and combined antibiotic therapy.

The effectiveness of penicillin G, fosfomycin, and cefoxitin alone and in combination was studied in vitro and in the treatment of left-sided Streptococcus sanguis endocarditis in rabbits. In vitro, the combinations penicillin G plus fosfomycin, penicillin G plus cefoxitin, and fosfomycin plus cefoxitin were synergistic or partially synergistic for S sanguis. Therapy with the combinations was more effective in eradicating the species from cardiac vegetations that was that with each antibiotic used alone.

Animals↗
PubMed1981

Fosfomycin penetration into the cerebrospinal fluid of patients with bacterial meningitis.

A comparative study was made of the penetration of fosfomycin, penicillin G, ampicillin and chloramphenicol into the cerebrospinal fluid of patients with meningitis treated with combinations of fosfomycin and one of the other three antibiotics. Minimal inhibitory concentrations and in vitro interaction of these antibiotics against Streptococcus pneumoniae and Neisseria meningitidis strains were determined. 90-96.5% of these strains were sensitive to penicillin G, 95-96.5% to ampicillin, 85-100% to chloramphenicol and 90-100% to fosfomycin. Fosfomycin shows a more marked synergism with penicillin G or ampicillin than with chloramphenicol against both bacterial species. The percentages of penetration into the cerebrospinal fluid were: chloramphenicol, 32%; fosfomycin, 25.7%; ampicillin, 15.9%, and penicillin G, 7.9%. The clinical results show that the combination of fosfomycin + penicillin G or fosfomycin + ampicillin can be an alternative in the treatment of meningitis produced by moderately susceptible strains of S. pneumoniae and N. meningitidis to penicillin G and ampicillin.

Aged↗