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Biomedical subjects

A Rodríguez

Publications and source records attributed to A Rodríguez.

At least 307 records · Page 17Linked to original sources
PubMed1980

Comparing the "family set" approach to estimate heritability with other conventional estimators: a Monte Carlo simulation.

A Monte Carlo simulation is performed to study the distribution of the family set estimators of heritability and to compare their performance with that of some conventional estimators used in human genetics. Comparisons of statistical properties among the two family set estimators (one based on the partial regression coefficients of the index's values on those of sib and cousin, respectively, and one based on the variances of the differences between the phenotypic values of index and cousin and of index and sib) and the three conventional estimators (one based on regression of index value on midparental value, another based on the sib-sib correlation, and the last one based on the index-cousin correlation) are also made under two genetic models.

Analysis of Variance↗
PubMed1979

Bromocriptine in the treatment of hyperolactinemic amenorrhea.

Thirty women with secondary amenorrhea and hyperprolactinemia were studied; galactorrhea was present in 25 of them, and 18 were infertile. Serum prolactin (PRL) levels were high in all cases, between 26 and 120 ng/ml. All women were treated with bromocriptine in increasing doses from 2.5 to 5.0 or 7.5 mg daily, according to the response obtained, for 4 months. In 27 patients a PRL determination was performed during treatment; values returned to normal (up to 20 ng/ml) in 23 women and remained high in 4. Galactorrhea disappeared in 21 of 25 women. Ovulatory menses were re-established in 17 patients (56.6%). Seven women became pregnant (38.8%), one of them after bromocriptine and clomiphene were given simultaneously in the same cycle. According to our results and a literature review the following conclusions may be drawn: (1) bromocriptine is a useful therapeutic tool for re-establishing menstruation and inducing ovulation in patients with the hyperprolactinemic-amenorrhea syndrome; (2) the association of bromocriptine and clomiphene could be the next step in the treatment of patients who fail to ovulate with bromocriptine alone.

Adolescent↗
PubMed1979

Diffusion of beta-lactam antibiotics and fosfomycin to interstitial tissue fluid in rabbits.

The ability of seven antibiotics (carbenicillin, cloxacillin, ampicillin, cephalothin, cephaloridine, cefoxitin and fosfomycin) to enter interstitial tissue fluid was evaluated. Using rabbits with implanted subcutaneous chambers, antibiotics were given intramuscularly as a single dose of 15 mg/kg, and antibiotic levels in serum and interstitial fluid of the chambers were determined at variously scheduled times after injection. The results indicated that antibiotic concentrations in the two compartments did not run parallel. The pharmacokinetic analysis showed that, in general, antibiotic diffusion from blood to interstitial fluid increased with the concentration gradient and the serum half-life, and there was an inverse relationship to pKa, protein binding and molecular weight of the antibiotic.

Animals↗
PubMed1979

Vascular obstructive alterations related to chorio-retinitis.

Different stages of retino-choroiditis, many of toxoplasmic origin, may develop vascular alterations. One of these pictures has been observed in relation to old scars of retino-choroiditis, where focal vasculitis may affect the venous return circulation sometimes leading to intraocular hemorrhages and retinal holes of variable severity. The natural history of this process is described, as well as the clinical characteristics and the results of treatment. Generally, the disease has a favorable course and a good prognosis. 18 cases are reported.

Adult↗
PubMed1978

Dynamics of estrogen binding by uterine cells in vivo.

The dynamics of the in vivo binding and release of tritiated estradiol in different uterine cell types are described. The very early binding of estrogens by the cytosol-nuclear and the eosinophil receptor systems is in accordance with the hypothesis that some estrogenic effects are mediated by these receptor systems.

Animals↗
PubMed1978

[Protracted diarrhea. Etiopathogenia and management (author's transl)].

For the purpose of twelve cases on protracted diarrhea, the etiopathogenia from this illness is reviewed and the tolerance and inconvenients of treatment with intravenous feeding is assessed, being the authors addicted of employing antibiotics, cholestyramine, diets free of disaccharides and fundamental diets; in such a manner that parenteral nutrition for its inconvenients and complications should only be used in case of failing the rest of therapeutic methods.

Diarrhea, Infantile↗
PubMed1977

Effect of propranolol on various parameters of estrogen stimulation in the rat uterus.

Pretreatment with propranolol does not modify the estrogen-induced uterine eosinophilia, the water imbibition effect, nor the increase in uterine RNA and protein content. This confirms the independence of these parameters from the estrogen-induced early increase in uterine cAMP, since, when observed, the latter is suppressed by propranolol pretreatment.

Animals↗
PubMed1977

Fosfomycin: Laboratory studies.

Fosfomycin, a nontoxic broad-spectrum antibiotic, different in structure from all previously described antibiotics, acts selectively by inhibiting cell wall formation. It was overlooked during many years of screening because of antagonism by culture medium ingredients and frequent occurrence of resistant mutants. It is effective in many because the neutralizing substances are not present and resistant mutants of most species are avirulent. Fosfomycin has favorable pharmacologic characteristics. It is not cross resistant, does not show antagonism, and has been used successfully in combinations. An insoluble calcium salt is used in oral formulation and a sodium salt for parenteral administration. Overall success rates of 86% were reported with 1,000 patients in Spain and 79% in Japan.

Animals↗