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Biomedical subjects

A Rossolini

Publications and source records attributed to A Rossolini.

At least 55 records · Page 3Linked to original sources
PubMed1976

[The effects of staphylococcal alpha toxin on regenerating liver (author's transl)].

The effects of staphylococcal alpha toxin on regenerating liver of partially hepatectomized rats are studied. Sixty six rats are used. They are divided into three groups of twenty two animals each one. The first group included untreated animals, the rats of second and third group are injected with 0,1 UE of staphylococcal alpha toxin, respectively soon after hepatectomy (second group) and after twenty two hours (third group). As parameters we used: mitotic activity, percentage of hepatic regeneration, the contents of liver water and proteins. The results are: a low letality in all the animals, a lower mitotic activity in all treated animals than in the intact ones, the percentage of restoration, the contents of water and proteins are the same in all the animals of the three groups. The AA. conclude that staphylococcal alpha toxin has a little negative mitotic effect on partially hepatectomized rats liver.

Animals↗
PubMed1975

Effects of E. coli O 127 endotoxin on regenerating rat liver.

The Authors investigated the effect produced by endotoxin upon regenerating rat liver. The animals were divided into three groups after hepatectomy. The first group of animals received physiological solution, the second group received 0.5 mg of E. coli endotoxin soon after hepatectomy and the last group received the same quantity of endotoxin 22 hours after hepatectomy. To estimate hepatic regeneration we used: percentage of liver regeneration and mitotic activity. It was noted that the percentage of hepatic regeneration and mitotic activity were higher in the two groups of treated animals than in the control group. Mitotic activity and hepatic regeneration were higher in the animals treated 22 hours after hepatectomy than in the animls of second group. These results lead us to conclude that E. coli O 127 endotoxin is mitogenic also in vivo.

Animals↗
PubMed1974

[Production of penicillinase as a parameter of the pathogenicity of staphylococci].

The research was conducted on 211 strains of Staphylococcus isolated in the three-year period 1972-1974- The coagulase, the hemolytic quality, mannite fermentation, pigment and penicillinase production were studied. The 211 strains of Staphylococcus were divided into 2 groups according to their origin: the 1st group included germs isolated from material which was certainly pathological, the 2nd group included strains isolated from various sources (throat, nasal, rectal, swabs, urine). The results, summarized in the Tables, led to the conclusion that even if the coagulase is the most significant characteristic in establishing pathogenicity of the Staphylococcus, the production of pigment and penicillinase also prove to be valid parameters of pathogenicity.

Coagulase↗
PubMedDate not supplied

Two-dimensional electrophoresis analysis of human serum proteins during the acute-phase response.

The serum of patients with meningitis, due to infection by Haemophilus influenzae type b, was analyzed. Several known acute-phase proteins were separated by two-dimensional electrophoresis and estimated quantitatively. In addition, hitherto undescribed reactants were recognized. Gels were calibrated and relevant spots related to master spot numbers in the human serum protein database.

Acute-Phase Proteins↗
PubMedDate not supplied

[Changes of various lipid fractions in experimental intoxication with diphtheric and tetanic toxins].

In the present study , the Authors have examined the effects of diphtheria and tetanus toxins on the lipid metabolism in the rabbit. Ten animals were treated with diphtheria toxin (five with 1 DL50 and five with 5 DL50 guinea pig). Ten animals were treated with tetanus toxin (five with 1 DL50 and 5 with 5 DL50 guinea pig). Finally, five animals were used as controls. The total lipids, the two cholesterol fractions, the total cholesterol, the triglycerides and the NEFA were measured 4, 24, 48, 72 and 96 hours after the beginning of the experiment. The animals treated with diphtheria toxin all died within 48 hours, and only those given the higher dose of toxin showed an increase in NEFA, found immediately before they died. The animals treated with tetanus toxin all survived and only those injected with the higher dose of toxin showed an increase in the esterificated fraction of cholesterol. The Authors conclude by affirming that the two toxins tested do not have significant influence on the lipid picture in the rabbit.

Animals↗
PubMedDate not supplied

[Effects of cholera toxin on the regenerating rat liver (author's transl)].

Two groups of animals were treated with cholera toxin respectively with 10,000 B.D. and 20,000 B.D. soon after hepatectomy. The parameters used were: the percentage of liver regeneration, mytotic activity and the liver protein content. The resulting differences between the controls and the two groups of animals treated were not statistically significant. The Authors conclude that cholera toxin does not affect the liver regeneration in the rat.

Animals↗
PubMedDate not supplied

[Evaluation of the specific immune response after anti-rubella vaccination].

A selective rubella immunization program was carried out in the Siena (Italy) area since 1984. 912 schoolgirls aged 10 to 18 were screened for rubella antibodies. Seropositivity rates, increasing with age, appeared quite heterogenous among subjects living in different villages. Seronegative girls were partly voluntarily immunized with RA 27/3 live attenuated rubella vaccine. Serological and clinical controls performed on 238 subjects one month after immunization showed a 99.6% vaccine-induced seroconversion rate and mild post-vaccinal reactions in 26% of vaccinees. Serological control performed, on 172 subjects, at 8-12 days after vaccination revealed that in most cases vaccine induced haemagglutination-inhibiting antibodies are not detectable at the time. The results are discussed in relation to a forthcoming introduction of compulsory rubella vaccination in our Country.

Adolescent↗
PubMedDate not supplied

[Changes in some blood lipid fractions in experimental poisoning with streptococcal toxin].

After an short bibliographic records in the relation between the endotoxine and lipydic metabolism, the AA. expose an inquiry on the rabbit. Ten rabbits (weight 2500-3000 g) were traited with 10 U.E. (haemolitic units) of streptococcal toxine (1/10 of DL50 for the rabbit). A conspicous increase of all the fractions examined, was remarked in all traited animals. The total lipids and the triglycerides reached the biggest value at 24 hours. Even the two fractions of cholesterol have increased, but the biggest concentration was at 48 hours. An hypotesis of interpretation can be that the streptococcal toxine produce the modification of lipidemic outline with the iperincretion of catecolamine, as in first phase of all toxinfections processes.

Animals↗