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Biomedical subjects

A Rossolini

Publications and source records attributed to A Rossolini.

70 records · Page 4Linked to original sources
PubMedDate not supplied

[Changes in some blood lipid fractions in experimental poisoning with alpha staphylococcal toxin].

The AA. have studied the effects provoques by alpha staphylococcal toxin in the lipidemic panel of the rabbit. Of 15 rabbits, five were injected with 0.25 emolitic units (U.E.) five with 1 U.E. and five ad control. The blood from heart was frequently with drawed and examined. In the animals traited with lowest dosis of toxin, the two fractions of cholesterol have increased with the maximum at the last control (96 hours). With a quadruple dosis of toxin increased also the total lipids and triglyceridis with the maximum at 48 hours. Remarked after all the different behaviour of the two fractions of cholesterol at the various dosis. The AA. conclude that the staphylococcal toxin provoque at low dosis only the modification on the cholesterol but at greater dosis also of the triglycerids and phospholipidis.

Animals↗
PubMedDate not supplied

[Changes in the blood lipid pattern in experimental poisoning with lipopolysaccharides of E. coli O 127].

After a short notice on the relations between the endotoxine and lipydic metabolism the AA. refer on the inquiry on 60 animals divided in three groups according to the dosis of the injected endotoxin. The dosis were 0.010-1-5 mg of the lypopolisaccaride from E. coli O-127; seven animals were appointed as controls. In the all animals were examined proofs of blood after 4, 12, 24, 36, 48, 60 and 72 hours from the start of experience. The total lipids, the triglycerides, the phospholypids, the NEFA, the free and esterified cholesterol were doses. The data of lethality and the value of determinations of the single fractions obtained were registered. In the all experienced animals, independently from the injected dosis, an independently from the injected dosis, an increase of the lypidic fractions was remarked: the free fatty acids were the first to rise, suived by triglycerides and phospholypids and denn by the two fractions of cholesterol. The highest dosis of endotoxine have comported a blok in the esterification of cholesterol. This early and persistent hiperlypemie can be caused initially by increased incretion of catecolamine.

Animals↗
PubMedDate not supplied

[Rubella vaccines (author's transl)].

After a short report about clinical features of teratogenic effect of rubella virus, the pecularities of several vaccines are reported. Vaccine efficacy and reactions, and rubella vaccine programmes are examined. The immune responses induced by rubella vaccines are described and particularly about the duration of humoral and cellular factors. The AA. discuss about the possibility to use a killed vaccine or a vaccine without teratogenic effect or the experience to give vaccine intranasally.

Antibodies, Viral↗
PubMedDate not supplied

[Vaccination against poliomyelitis].

The authors, after a review of some data about the actual poliomyelitis epidemiology in the world, point out the necessity of periodical checks for poliomyelitis vaccination. To this purpose, preliminary data of a research, undertaken in the province of Siena, into the effectiveness and innocuity of oral poliovirus vaccine, are reported. This evaluation has been made through isolation and identification of vaccinal polioviruses from stool after the first, second and then third dose of vaccine, and through titration of serum neutralizing antibodies. Results confirm the high effectiveness and innocuity of oral poliovirus vaccine, but suggest the opportuneness of some changes in the way of giving the oral vaccine.

Antibodies, Viral↗
PubMedDate not supplied

[Effects of streptococcal toxin on hepatic regeneration in the rat].

The liver regeneration percentage, mytotic activity and protein content were used to demonstrate the effects of streptococcal toxin on regenerating rat liver. No statistically significant difference was showed between controls and toxin treated animals. Serum level of C, resulted on the contrary, considerably reduced in the animals treated with streptococcal toxin.

Animals↗
PubMedDate not supplied

[Vaccination against rubella].

The infection caused by the rubella virus is a mild disease usually with no or rare complications in children and adults. On the contrary, intrauterine fetal infection may result in defects of the child, which may either be present at birth or become apparent later in life. Such a risk led to the preparation and use of active immunoprophylaxis against rubella in females of child-bearing age, in order to prevent congenital rubella. Three rubella viruses are employed to prepare the vaccine, all derived from the same viral strain. Doubts however, exist about vaccination, in particular about (1) its teratogenic potential in pregnancy; (2) the duration of protection. As a matter of fact, congenital malformations in the fetus exposed to vaccine virus through the mother have been reported in 3% of cases. As to the second point, the data on the protective immunity in time of the vaccine are very controversial. It is clear, anyhow, that protection against infection is associated not only with persistence of adequate serum levels of antibody, but also with other immunological parameters which are still unknown. These considerations, together with the observation that a relative high percentage of vaccine recipients do not respond, lead us to suggest modifications in the present scheduling of immunization against rubella.

Antibodies, Viral↗
PubMedDate not supplied

[Neonatal meningitis (personal contribution)].

The authors, after a review of the literature about etiology, pathogenesis, epidemiology, pathological anatomy and clinic of newborn meningitis, report a personal experience of 15 cases. The more frequent etiological agents were Gram-positive bacteria (60%) and in particular Listeria monocytogenes type 4 and Streptococcus agalactiae. Gram-negative bacteria were isolated in 40% of cases and E. coli presented the highest ratio. All patients were treated with ampicillin-CAF association intravenous for the first 3-5 days and then i.m. or oral. The survival ratio was 77% in case of Gram-positive meningitis and 83% in case of Gram-negative meningitis. Sequeles were observed only among patients with Gram-negative meningitis; it's important to remark that in these cases the etiological agent was CAF-resistant.

Chloramphenicol↗
PubMedDate not supplied

[Study on 190 strains of "staphylococcus aureus" isolated in a department of ophthalmology (author's transl)].

Biochemical features and sensitivity to chemotherapeutic agents of 190 strains of Staphylococcus isolated from pharinx and conjunctiva of ophtalmological patients and staff were studied. Each strain was investigated for: pigment, coagulase, hemolysis (alpha-toxin), phosphatase and penicillinase production and mannite fermentation. Twentyfour chemotherapeutic angents were used for sensitivity tests. The Authors emphasize that a positive coagulase test is the best laboratory evidence for pathogenicity of a given strain of Staphylococcus, and that the site of isolation of the examined strains is not related with their biochemical features and sensitivity to chemotherapeutic agents.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Nucleic acids in the liver of rat treated with "E. coli" O 127 lipopolysaccharide (author's transl)].

The Authors have studied the variations of nucleic acids, proteins and histological aspect in the liver of rats, treated with 1 mg of E. coli ) 127 lipopolysaccharide and killed at 24th, 48th, 72th, 96th hour after the inoculation. The endotoxin determines an increase of nucleic acids and a reduction of hepatic proteic contents. The histological observation shows throw-back phenomenons of the hepatocyte with hyperplasy and hypertrophy of Kupffer cells at 24th hour, while at following intervals the phenomenous of hepatic rigeneration emphasize.

Animals↗