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Biomedical subjects

A S Ginsberg

Publications and source records attributed to A S Ginsberg.

7 recordsLinked to original sources
PubMed2001

Antithrombotic therapy during pregnancy.

Antithrombotic therapy is required during pregnancy for the prevention and treatment of venous and arterial thromboembolism and for the prevention of pregnancy loss in women at risk. The choice of anticoagulant for venous thromboembolism during pregnancy is limited to unfractionated heparin or low molecular weight heparin because the use of warfarin is relatively contraindicated. Much of the information surrounding the pharmacokinetics and dosing of unfractionated heparin and low molecular weight heparin obtained from non-pregnant patients has been applied to pregnant women. Whether this is appropriate in the presence of significant physiological changes in pregnancy is unclear. Specific to pregnancy and unfractionated heparin use, activated partial prothrombin time may be unreliable. In addition, the appropriate dosing of low molecular weight heparin is uncertain. Because venous thromboembolism can cause significant maternal morbidity and mortality, these important issues surrounding appropriate drug dosing of anticoagulants should be addressed.

Female↗
PubMed1987

A defined medium for a fastidious Spiroplasma.

A defined medium (H-1) was developed for cultivation of the suckling mouse cataract agent, Spiroplasma mirum, a fastidious member of the class Mollicutes that causes cataracts and chronic brain infection in inoculated neonate mice. The H-1 medium was used to show the importance of sphingomyelin as a growth factor for the culture of the spiroplasma in vitro. The growth of Spiroplasma mirum and the pathology it induces in sphingomyelin-rich tissues in vivo may be related to this dependency.

Animals↗
PubMed1987

Cell-assisted culture of fastidious spiroplasmas: initial analysis of growth factors.

Half of the spiroplasmas observed microscopically in insects cannot be cultivated and are thus inaccessible to study. Media mixed with cultured insect cells have now been used to isolate two of these spiroplasmas--the sex-ratio organism (SRO) of Drosophila and the Colorado potato beetle spiroplasma (CPBS). Studies described herein indicate that at least one of the cell-supplied factors is involved in redox maintenance. A wide variety of insect cell culture systems were suitable for primary isolation of the CPBS. The SRO and CPBS were found to attach to insect cells in vitro.

Anaerobiosis↗
PubMed1979

The effect of delay rules in controlling unscheduled visits to hospitals.

The increased demand of unscheduled visits to hospital outpatient facilities, and particularly to walk-in clinics, necessitates the consideration of means to control this flow and to reduce in-hospital waiting times. A model is developed in which a percentage of the unscheduled visits are assumed to be delayable, e.g., patients with non-urgent complaints who call may be asked to delay their arrivals for specified lengths of time. A simple rule for determining, dynamically, the length of this delay was examined by computer simulation. The results demonstrate significant reduction of in-facility waiting times while only marginally increasing the time patients wait from their initial contact with the clinic until seen by a practitioner.

Appointments and Schedules↗