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Biomedical subjects

A Sh Zaĭchik

Publications and source records attributed to A Sh Zaĭchik.

At least 19 recordsLinked to original sources
PubMed1990

[Pancreatic hormonal function and proteolytic activity in peptic ulcer].

Blood serum insulin, glucagon, pepsinogen, trypsin was studied by radioimmunological methods in 95 patients with ulcer disease. Fasting values and values 1 and 2 hours after a standard breakfast (1212 kcal) were evaluated. It was established that all patients showed a statistically valid increase of the basal level of glucagon while patients with gastric ulcer showed an increase of the basal insulin level. Use of a test breakfast showed reserve and compensatory capacities of the hormonal pancreatic function. Patients with gastric and duodenal ulcer revealed an increase of the pepsinogen level under conditions of basal secretion and after a test breakfast.

Adolescent↗
PubMed1985

[Physiological significance of specific immunoglobulins in regulating steroidogenesis in adrenal cortex cells].

The data obtained suggest the existence of physiological immunoglobulin mechanisms regulating the functions of the cells including hormone--producing ones. Serologically identical antigens were revealed both in the blood and the extracts from adrenocortical cell nuclei of intact rats. Apart from that, autoantibodies to deoxyribonucleoprotein (DNP) of adrenocortical cells were found in the blood sera of normal animals. Immunoglobulins G (ig G) against adrenocortical cell nuclei, DNP and the nuclei partially devoid of DNP, were produced. The specific IgG were shown to stimulate the steroidogenesis in target cells. The penetration of the specific antibodies into the target cell nuclei in vivo was proved. The data obtained support the hypothesis of the nuclear mechanisms of antibody--caused cytostimulation.

Adrenal Cortex↗
PubMed1983

[The endocrine system and immunity].

The studies using antinuclear and antideoxyribonucleoprotein immunoglobulins of the G class from hormone-producing cells against specific structures of the adrenals, thyroid gland, and thymus exerting an selective organ-specific effect and an immunomodulator thymaline (a thymus factor) in the structural-functional analysis revealed previously unknown mechanisms of interaction of the endocrine system and immunogenesis organs. These data may facilitate the elucidation of the mechanisms of levelling of disturbed homeostatis.

Adrenal Glands↗
PubMed1980

[Mechanisms of cellular dedifferentiation in the adrenal cortical substance].

Hypothyreosis or the injection of actinomycin D have been shown to reduce the expression in dedifferentiation changes that take place in the fascicular and reticular zones of the adrenal gland cortex of hypophysectomized rats. The reduced intensity of such a dedifferentiation may occur due to the suppression of m-RNA synthesis, the character of the power resulting in the inhibition of DNA-dependent polymerase (actinomycin D or hypothyreosis) having no real significance.

Adrenal Cortex↗
PubMed1978

[Change in the specific functions of cells under the influence of antibodies].

Antibodies against the nucleic fraction are capable of activating specified functions of hormone-producing cells. Stimulation of hormone production may occur even when protein synthesis is blocked by puromycine. A possible mechanism of the action of antibodies against the nucleic fraction of endocrine gland cells is a derepressing of enzyme system responsible for biosynthesis of specific hormone substances.

Adrenal Cortex↗
PubMedDate not supplied

[Laser therapy in acute nonspecific epididymo-orchitis].

Laboratory experiments were followed by clinical investigations of low-intensity laser radiation (LR) feasibility in therapy of acute epididymo-orchitis. A total of 117 patients aged 15-68 were treated with mild, moderate and severe scrotal inflammation. The response was compared to that in physiotherapy (54 patients) and early surgery (40 patients). It proved higher by 38.5%, the proportion of the treatment failure diminished from 22.2% for conservative and 15% for surgical management to 7.7%. The duration of acute inflammation reduced to 3 days. There was a marked analgetic effect, arrest of intoxication, hyperthermia, autoimmune reactions. Scarring could be avoided. The discussion covers mechanisms of therapeutic action of laser therapy which is proposed for broad-scale application in any run of the inflammation. The test is suggested for the final choice of therapy to be made on day 2-3 of laser irradiation.

Acute Disease↗
PubMedDate not supplied

[Effect of immunostimulants of steroidogenesis on the activity of various oxidative enzymes in the adrenal glands and other organs].

Effect of IgG from rabbits, immunized with deoxyribonucleoprotein and with nuclear matrix of rat adrenal glands, on activities of cytochrome c oxidase, glucose-6-phosphate (G6PD) and lactate (LDH) dehydrogenases was studied in rat adrenal glands, liver and spleen tissues, myocardial and skeletal muscles. After administration of the antibodies and deoxynucleoprotein activation of the oxidative enzymes was tissue-dependent. Activities of cytochrome c oxidase and G6PD were distinctly increased in adrenal glands. In other tissues studied the enzymatic activity was not either increased (spleen, myocardium, skeletal muscle) or mediated through adrenal glands (liver tissue). The tissue-dependent activation of the oxidative enzymes, which accompanied the steroidogenic effect of the immunoglobulins studied, was considered as a result of interaction between the antibodies and tissue-specific antigen determinants in adrenal gland chromatin.

Adrenal Cortex↗