Biomedical subjects

A Soren

Publications and source records attributed to A Soren.

At least 19 recordsLinked to original sources

PubMed1997

Chondropathia patellae.

The articular surface of the patella and the contiguous articular surfaces of the femoral condyles are sometimes affected by disintegrational changes of the articular cartilage, which remain localized there for a longer period of time. In consideration of the pronounced functional impairment arising at marked changes of these articular surfaces, resection of the patellar surface, metallic resurfacing of the patella, periosteal resurfacing of the patella, or patellectomy have been described as treatment by various authors. Most of these modalities were followed by shortcomings of the results, as indicated in pertinent follow-up examinations and reports. Thus, a more physiological modality of treatment, organic resurfacing of the patella with synovial tissue, was applied in 7 patients and led to satisfactory results as ascertained by long-term follow-up examinations.

Adult↗

PubMed1996

Contracture of the shoulder joint.

The movements of the shoulder joint may sometimes be markedley limited due to posttraumatic or inflammatory changes in the shoulder joint or in adjacent organs, a condition designated as contracture of the shoulder joint or frozen shoulder. The routine treatment consists of positioning the arm as often as possible in abduction, and of diligent active and passive mobilization exercises. In those patients who started the treatment after a long delay so that the articular as well as the periarticular tissues were very shrunken, manipulation of the shoulder joint was carried out under general anesthesia this led to the return of full motion of the joint in the great majority of these patients. However, in those patients who did not benefit by manipulation, surgical revision of the joint and of periarticular structures was carried out for excision of all scarified tissues. The result was restoration of the mobility of the joint to an adequate although not total range.

Adult↗

PubMed1994

Patella partita.

Patella partita is a malformation of the knee cap, generally characterized by one or a few vertical lines of discontinuity in sagittal planes, caused by incomplete ossification within a single ossification center. In other cases, disorder of ossification in frontal planes results in frontal subdivision of the patella. While patella partita is sometimes diagnosed as a coincidental radiographic finding, in other cases, especially in elderly individuals, it is a finding associated with symptoms which require treatment.

Humans↗

PubMed1986

The course of inflammation exemplified in the synovial membrane. Personal studies and literature data.

Owing to special reactivity anchored in its structure the connective tissue responds to all kinds of injuries with tissue changes which in their completeness are designated as inflammation. An expressive carrier of mesodermal inflammation is the synovial membrane in which these tissue changes are manifested at first by the vessels and cells of the blood, and subsequently by all other constituents of the synovial membrane.

Collagen↗

PubMed1985

On the etiology of congenital malformation of the meniscus.

In order to explain the occurrence of malformed meniscus in man, dissections were carried out in various vertebrates; they revealed that menisci shaped like a plate, disc, or ring are physiological components of the knee joint in several vertebrates. Microscopic examinations of tissue sections through the knee joint of human embryos revealed that the meniscus develops from an intermediate mesodermal blastema, which has the shape of a thick plate in the early embryonic period. The occurrence of a malformed meniscus in man may be explained by persistence of a very early embryonic stage and also possibly by reversal to a phylogenetic shape.

Amphibians↗

PubMed1985

Spondylolisthesis and related disorders. A correlative study of 105 patients.

A close relation exists among the alterations in the lumbosacral spine designated as spondylolysis, isthmic spondylolisthesis, degenerative spondylolisthesis, and prespondylolisthesis. While the former two conditions are probably caused by faulty development and subsequent minor traumata or repeated stresses, the third condition is caused by degenerative changes associated with anatomic variations; the fourth condition is a static insufficiency leading to faulty alignment. In 105 patients, the initial preferred management of these conditions was conservative. Thirty-four patients who developed persistent symptoms of spinal instability and/or intractable neurologic deficits were treated surgically. The results were generally successful.

Adolescent↗

PubMed1983

The morphologic and pathogenetic bases of heterotopic bone formation in the extremities.

Heterotopic bone formations, involving the insertional portion of a tendon, fascia or ligament, were observed in the extremities. Histopathological examinations suggest that the connective tissue is transformed by direct metaplasia into bone tissue. The development of ossification is favored by the special structure of the connective tissue in these areas. Whereas in a small number of these cases a trauma could be identified as the competent cause, in the majority of the cases excessive or repeated minor stresses probably accounted for the ossification; in other cases with no obvious stresses a constitutional overreaction of the connective tissue had to be assumed as an explanation for the occurrence of ossification.

Connective Tissue↗

PubMed1982

Pathogenesis, clinic, and treatment of ganglion.

In clarification of various theories on the pathogenesis of the ganglion, histopathologic examinations indicate that the ganglion develops from connective tissue by myxoid degeneration and disintegration of collagen fibers. Increasing amounts of mucinous fluid accumulate by the progressive liquefaction of collagen fibers and are surrounded by densifying collagen bundles which form a delimiting capsule. In view of the inadequacy of conservative treatment and the shortcomings of excision, the subcutaneous (s.c.) discission of the ganglion with a tenotome is recommended. Of 184 patients treated this way, 151 displayed full healing, six underwent a successful repetition of the procedure, nine underwent an excision of the recurrent ganglion, and 18 rejected further treatment.

Humans↗

PubMed1982

[Changes in the synovial membrane in psoriatic arthritis].

The structural changes of the synovial membrane in psoriatic arthritis are described. Typical features include focal and diffuse cell infiltrates with predominance of plasmocytes, pronounced response by synoviocytes, fibroblasts and fibrocytes, marked regressive alterations of small and middle-sized blood vessels, and finally dense extensive fibrosis. However, none of these histopathologic features solely occures as a pathognomonic change in psoriatic arthritis to permit the diagnosis of psoriatic arthritis on the basis of microscopic examination alone.

Adult↗

PubMed1981

Diagnostic specificity of synovial lesions.

Sections of synovium from 393 operations on diseased joints were re-examined without knowledge of the clinical findings. Specimens were scored for each of 37 histopathologic features. Independently, patients were assigned to one of 10 diagnostic groups after review of all available clinical data. Computer analysis revealed statistically significant differences in the incidence of one or more histologic parameters between the members of all except three of the possible disease pairs. The possibility of exploiting these differences to increase diagnostic precision was examined.

Adolescent↗

PubMed1981

A statistical approach to the histopathologic diagnosis of synovitis.

Synovial tissue from 393 operations on diseased joints were scored for each of 37 histopathologic variables; the patients fell into 10 clinically defined diagnostic categories. The five most populous of these diagnostic groups provided a data set for calculating diagnoses based on histopathologic findings. For each pair of clinical diagnostic categories we derived a linear discriminant function dependent solely on the histopathologic assessments. The functions gave a numerical score for segregating each case into one of the diagnostic categories. The histopathology based diagnoses agreed with the clinical diagnoses in 54 to 78 per cent of the cases. Illustrations of the application of this technique are presented.

Arthritis↗

PubMed1981

The giant cells in the synovial membrane.

Histopathological examinations of synovial tissues, obtained in 393 operations, disclosed the presence of foreign body giant cells or synovial giant cells or both in 51 cases. The presence of the former could be related to the occurrence of material foreign to the location, whereas for the latter group fo coincidence of precipitated fibrin only was noted in a significant number of cases. The patients operated upon were classified by 10 diagnosed entities of joint disease, and the synovial giant cells, lysing among synoviocytes or in the subsynoviocytic tissue, were observed in 8 of these categories. Thus no diagnostic significance could be attributed to the giant cells.

Humans↗

PubMed1980

The historical evolution of arthrodesis of the foot.

Arthrodesis is the term coined by Albert for the operation whose purpose is to induce ankylosis of a joint by denuding it of cartilage. Whereas arthrodesis of the foot was initially used for paralytic conditions, its use has progressively widened. Numerous modifications of the original procedure have been developed, and with increasing experience the indications for each type of arthrodesis has been more clearly defined. Basic principles have emerged: a) To apply arthrodesis of the foot to stabilise joints, to correct deformity, to eliminate joint disease and pain: b) To limit arthrodesis to the minimum number of joints; c) To denude the articular surfaces congruently in order to enhance ankylosis; d) To add, where indicated, either bone grafting to enhance fusion or tendon transfer to prevent recurrent deformity.

Arthrodesis↗

PubMed1980

Surgical correction of hallux valgus.

Surgical treatment of hallux valgus was carried out by a procedure which comprises lengthening of extensor tendons, interposition of a capsular flap, and attachment of the periosteocapsular cover with distributed tension in addition to the routine excision of a sufficiently large portion of the first phalanx and metatarsal head. Impairment of function and persistent pain were considered more important in the indication for operation of hallux valgus than the cosmetic demands. Of 142 patients operated upon, 117 patients displayed a satisfactory result applying morphologic and functional criteria.

Female↗

PubMed1980

[Safe inlay of bone sgraft in arthrodesis].

Adequate blood supply and complete immobilization are basic requirements for the successful outcome of denudation arthrodesis. These requirements can be ensured by an arrow-shaped bone graft which is impacted in reverse direction into the denuded articular ends. Forthy-three of fifty operated ankle joints and all six operated wrist joints showed satisfactory fusion.

Adolescent↗

PubMed1980

[The pathology of ganglion].

Ganglia are cysts which frequently occur in the proximity of joints. Histopathologic examinations disclose that these formations do not originate from articular tissue, but independently of this develop from degenerating nonspecific connective tissue. By progressive myxoid decomposition of collagen fibers larger amounts of mucinous fluid accumulate, and spread the adjacent collagen fibers apart, thus forming cavities filled with thickening fluid. With further liquefaction of some interstitial septa some cysts coalesce and widen, until eventually other septa and the surrounding capsule become dense by increase of fibrocytes and thickening of the collagen bundles.

Connective Tissue↗

PubMed1978

The synovial changes in post-traumatic synovitis and osteoarthritis.

The histopathologic appearances of post-traumatic synovitis and synovitis of osteoarthritis cover a limited range of changes and have features in common. Electron microscopy yields information complementary to that given by light microscopy. With these techniques, based on sufficient material, histological analysis linked with clinical observation will permit some degree of differentiation between the two conditions.

Adolescent↗

PubMed1978

[Kinetics of salicylates from the blood to the articular fluid].

A study was made of the salicylate concentrations in samples of blood and articular fluid from 30 patients treated with acetylsalicylic acid. The data were divided in groups according to the diagnosis of the articular diseases and showed no significant differences as regards the salicylate kinetics in the blood. A concentration of 0.3 mg/1 was reached in 6 minutes on the average and the "near maximum" concentration was 23.0 mg/1 on the average. In the articular fluid a concentration of 0.3 mg/1 the salicylates was reached in 10 to 31 minutes. The average maximum concentration as 14.8 mg/1. The findings support the hypothesis that diffusion was the dominant factor in the passage of salicylates from the blood to the articular fluid. The transport varied with the characteristics of the articular diseases. Histopathological changes in the various types of synovitis would alter the biophysical properties of the internal part of the articularcapsule and would thus alter the kinetics of salicylates.

Arthritis↗