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Biomedical subjects

A Soren

Publications and source records attributed to A Soren.

At least 37 records · Page 2Linked to original sources
PubMed1978

Reduction and immobilization for Colles fracture.

Maintenance of reduction in Colles fracture can be difficult to achieve. Some of the positions of the wrist in plaster designed to prevent redisplacement produce subsequent difficulty in the recovery of function of the wrist and hand. The author has practised a technique, in a large number of cases, using plaster with radial and dorsal indentations, which has proved capable of maintaining reduction with the wrist in a "physiological" or neutral position. The details of the technique are described and the end results in 162 patients are analysed.

Casts, Surgical↗
PubMed1977

[Transport of salicylates from blood to joint fluid (author's transl)].

Samples of blood and joint fluid from thirty patients who had taken acetyl-salicylic acid were examined for occurrence of salicylates. The data were arranged in groups according to the diagnosis of the joint disease and did not show significant differences in the kinetics of salicylates into blood; the time of the first appearance averaged 6.4 minutes, and levels "close to maximum concentration" averaged 23 mg/l. In joint fluid, the time of first appearance of salicylates ranged from 10 to 31 minutes, and levels of maximum concentration of salicylates averaged 14.8 mg/l. Transport of salicylates from blood to joint fluid showed a pattern consistent with the type of joint disease. Support was found for the assumption that diffusion was the major factor in the movement of salicylates from blood to joint fluid.

Arthritis, Rheumatoid↗
PubMed1977

Dissociation of acetylsalicylic acid in blood and joint fluid.

Assay method in blood of 30 patients, who had ingested 0.6 g buffered aspirin, showed earlier appearance of acetylsalicylate (ASA) than of de-acetylated salicylate (SA); the values for ASA averaged 7.7 min, and for SA, 10.9 min. Similarly in joint fluid, ASA appeared earlier than SA; the values of ASA averaged 19.4 min, and those for SA, 21.9 min. Transport times did not differ significantly between ASA and SA in most types of synovitis. Close to maximum concentrations in blood averaged 18.9 mg/l for total salicylates (TSA), 3.3 mg/l for ASA, and 23.3 mg/l for SA, whereas maximum concentrations in joint fluid averaged 15.7 mg/l for TSA, 2.5 mg/l for ASA, and 14.5 mg/l for SA. ASA in blood initially consituted 65% of TSA and decreased to less than measurable amounts 75 min after intake. Joint fluid initially contained a somewhat smaller maximal proportion of ASA, but de-acetylation progressed more slowly than in blood; ASA decreased to undetectable levels within 140-145 min after intake.

Adult↗
PubMed1975

[Morphometric investigations' on synovial membranes of human knee joints. Statistical analysis (author's transl)].

Sixty knee joints of 49 autopsies and 10 amputated legs were examined histologically by specimens removed from eight locations. The criteria considered were: configuration of the surface, number of rows of synovial cells, sizes of bodies and nuclei of the synovial cells, position of the blood vessels to the synovial surface, degree of sclerosis both of the subsynovial connective tissue and blood vessels, and infiltrates of inflammatory cells. These parameters were recorded in tables, and 3,600 individual data were statistically evaluated by the aid of a PDP-12-computer. Survey of all findings shows that the age changes of the synovial membrane are relatively slight. With increasing body weight sclerosis of the synovial blood vessels progresses, but these vessels are sometimes spared in generalized arteriosclerosis. The greatest number of individual tissue changes is noted in the fat pad, medial and lateral capsular parts. Thus the synovial membrane of these parts may be regarded prominently reactive and of special value for the diagnosis of synovial changes. Since these parts are easily accessible at routine arthrotomies, they are recommended as the sites for diagnostic biopsies.

Adolescent↗