PubMed Health⌕ Search

Biomedical subjects

A Soren

Publications and source records attributed to A Soren.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Kinetics of salicylates in blood and joint fluid.

Samples of blood and joint fluid from 30 patients who had taken acetylsalicylic acid were examined for concentrations of total salicylates. The data were arranged in groups according to diagnosis of the joint disease. Analysis of the data did not show significant differences in the kinetics of total salicylates into blood. In groups, the time to first appearance of 0.3 mg/liter averaged 6 minutes, and levels "close to maximum" concentration averaged about 23.0 mg/liter. Time to first appearance of 0.3 mg/liter of total salicylates in joint lfuid ranged from 10 to 31 minutes. The average level of maximum concentration of total salicylates in joint fluid was 14.8 mg/liter. Transport of total salicylates from blood to joint fluid showed a pattern consistent with the type of joint disease. Support was found for the hypothesis that diffusion was the major factor in the process of movement of total salicylates from blood to joint fluid. The histopathologic changes in different types of synovitis influenced the biophysical properties of the inner part of the joint capsule.

Adult↗
PubMedDate not supplied

[Spondylolisthesis and related conditions; pathology, clinical aspects and treatment].

Close pathogenetic and morphologic relationships exist between the alterations of the lumbosacral spine designated as spondylolysis, spondylolisthesis and praespondylolisthesis. The initial management of 105 patients with such conditions was conservative. However, of this group 34 patients with persistent instability and/or intractable neurologic symptoms were subsequently treated surgically, and the majority of them obtained lasting benefits.

Adolescent↗
PubMedDate not supplied

Transport time for salicylates from blood to joint fluid-- a test of histopathology of the synovial membrane.

Samples of blood and joint fluid, from sixty patients who had taken Bufferin, were examined for salicylates. The earliest appreance of salicylates occurred in blood between 3 and 13 minutes after intake, and in joint fluid between 11 and 36 minutes. The individual time lapse from the first appearance of salicylates in blood to that in joint fluid, designated the transport time, varied presumably with the changes of the synovial membrane caused by diseases; it was small in synovitis following trauma or focal infection and in osteoarthritis of short duration; it was greater in osteoarthritis, psoriatic arthritis, and rheumatoid arthritis of longer duration, and it showed great variations in immediate traumatic synovitis. Salicylates attained maximum concentration in joint fluid 100 to 155 minutes after intake. Similar factors as above probably accounted for the differences in these time intervals.

Administration, Oral↗
PubMedDate not supplied

The nature and designation of osteoarthritis determined by its histopathology.

Specimens of synovial tissue and articular cartilage removed at operations of patients with primary degenerative joint disease were scrutinized for defined histopathological parameters. The findings in the synovial membrane were subsequently compared as to frequency and intensity with identical parameters ascertained in specimens removed from patients with definite rheumatoid arthritis. These examinations disclosed the presence of synovial inflammatory features, although at lesser incidence and intensity than in rheumatoid arthritis; therefore the designation of arthritis is indicated. On the basis of the concurrently examined tissue specimens of the articular cartilage, and in consensus with the generally acknowledged start of the degenerative joint disease by disintegrating changes in the articular cartilage, the prefix of chondrosis is appropriate.

Aged↗
PubMedDate not supplied

The alterations of the synovial membrane in rheumatoid arthritis treated with corticosteroids.

Sections of synovial tissue removed from patients with rheumatoid arthritis treated, for a long period of time or a brief period of time or not at all, with corticosteroids were examined for the incidence of histopathologic changes. Comparison of the quantification of these changes in the differently treated groups revealed that prolonged administration of corticosteroids had an inhibiting effect on the occurrence of lymphocytes and histiocytes in inflammatory infiltrates as well as on the hypertrophy of synoviocytes, on the proliferation both of fibroblasts and fibrocytes, and on the formation of villi and collagen fibers.

Adrenal Cortex Hormones↗