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Biomedical subjects

A Spring

Publications and source records attributed to A Spring.

At least 55 records · Page 3Linked to original sources
PubMed1990

[Tethered cord syndrome in adults as a cause of disorders of bladder function].

The histories of two adults with tethered cord syndrome are presented. Slowly increasing bladder dysfunction, dysraphic disorder and increasing sensorimotor deficits gave rise to the suspicion of tethered cord syndrome. The release of the cauda equina by transsection of the thickened filum terminale and in one case removal of lipomatous tissue in addition improved the bladder function and the sensorimotor function substantially. Diagnostic procedures and aspects of the prognosis are discussed.

Adult↗
PubMed1989

Tethered cord syndrome: progressive symptomatology in adults. Case report: symptoms, diagnosis, treatment.

Medical history and symptoms of a 37 year old woman showing progressive conus syndrome for nine months after a symptomless interval of 20 years are reported. NMR, myelography, and computed tomographic myelography verify a filum terminale with a paramedian fixation at the level of the lumbosacral angel and a further fixation at the caudal end of the dural sac at the lower end of the sacrum. The operative findings and procedures are described. The importance of control by neuro-stimulation of the filum terminale during surgery is stressed. The post-operative remission of most of the symptoms proves the success of the treatment.

Adult↗
PubMed1988

Brain death and intraocular pressure.

The authors report on the behavior of the intraocular pressure of 20 patients who had sustained severe head injury. The 8 patients who retained normal intraocular pressure all survived. The 12 patients who developed intraocular hypotony all suffered brain death. Although optic disc edema was not noted in any brain-dead patients, we did find signs of fundus ischemia in most.

Adolescent↗
PubMed1988

[Brain death and intraocular pressure].

The article reports on the changing behaviour of the intraocular pressure of 20 patients who had a severe head injury. Eight patients survived; in this group intraocular pressure was always normal. Twelve patients developed brain death, and in contrast to the group of survivors all of them had intraocular hypotension. Papilloedema was never seen in funduscopic examinations; however, we found signs of fundus ischaemia in most patients who had died of brain death.

Adolescent↗
PubMed1984

[The effect of the central gray matter in cats on pain during electric stimulation of the aqueduct].

In 54 cats electrical stimulation of the periaqueductal grey matter was performed by electrodes which were placed in distinct regions of the aqueduct. The influence on pain was studied by the formalin test. Motor behaviour was observed. The results show an obvious inhibition of pain reactions, which was most effective in the upper of the aqueduct. The motor functions were disturbed only in some cats with lesions of the cerebellar vermis. The advantage of this method is that it is not necessary to place the stimulating electrode into the midbrain tissue. This procedure might be appropriate for patients with severe chronic pain in face and body, in whom other surgical methods have failed.

Animals↗
PubMed1983

[Barbiturate therapy in neurosurgery].

Thirty patients with an acute midbrain syndrome were treated by high dose barbiturate therapy. Of these patients 19 had a severe head injury. In 8 patients the symptoms of acute midbrain syndrome developed after subarachnoid haemorrhage. In three patients these symptoms were caused by postoperative swelling or ischaemia. The results of those patients, who were treated with barbiturates after head injury were much better than in 16 other patients, who had no barbiturates. The indications for high dose barbiturate therapy in neurosurgery are discussed with reference to other publications and to the pathophysiological effects of barbiturates.

Adolescent↗
PubMed1983

Thiopental monitoring by gas-chromatography.

A gaschromatographic method is presented for the determination of thiopental (and of its metabolite pentobarbital) in cases of severe head injuries treated by induction of therapeutic barbiturate coma. To 1 ml serum the internal standard and saturated ammonium sulphate solution are added. The mixture is extracted by chloroform and the concentrated organic phase is injected into the gaschromatograph (stationary phase: SP 2510 DA). Imprecision from day to day: Coefficient of variation 7.7%; recovery 97%. The specificity was checked by comparison with the retention time of more than 80 drugs. One determination is accomplished within 1 hour.

Barbiturates↗
PubMed1983

[Effect of thiopental anesthesia on plasma renin, adrenaline and noradrenaline in neurosurgical operations with induced hypotension].

Excessive postoperative blood pressure reactions following surgery of cerebral aneurysms using sodium nitroprusside--induced hypotension can be avoided, if barbiturate-fentanyl-anaesthesia is employed instead of neuroleptanalgesia. Plasma renin activity (PRA), plasma concentration of adrenaline and noradrenaline were determined in 13 patients, undergoing surgery of cerebral aneurysms with induced hypotension (group I) and in 15 patients, who were operated on for brain tumors without hypotension (group II). The PRA was not increased in group II. The blood pressure was normal. In group I the PRA was significantly higher during and after the operation. In both groups adrenaline was not increased significantly. The noradrenaline concentration showed a significant increase in both groups, indicating a peripheral sympathetic stimulation. It is supposed that thiopentone inhibits the depletion of adrenaline and reduces the effect of increased PRA.

Adult↗
PubMed1982

Evaluation of a Tay-Sachs screening program on a college campus.

A screening program for Tay-Sachs disease was done on a predominantly unmarried, university student population and later evaluated. Ten carriers were detected among a population of 390 screened. Voluntarily screened individuals were given a questionnaire at the time of screening and after their carrier status was revealed. In addition, individuals in a target population were queried as to why they did not attend the screening. Results of evaluation indicate that both the screened and unscreened students were able to answer approximately two thirds of a set of questions on Tay-Sachs correctly, but there was widespread lack of knowledge regarding the implications of carrier status and inheritance of the disease. In general, respondents to the questionnaires were not opposed to abortion. However, when asked about the family planning alternatives that they would consider if they were carriers, more subjects preferred adoption, artificial insemination, or avoidance of pregnancy to abortion.

Abortion, Eugenic↗
PubMed1980

[Blood-level changes of lactate and pyruvate after osmotherapy with mannitol and sorbitol (author's transl)].

In 43 patients osmotherapy with Mannitol 20% and Sorbitol 40% was applied and the changes of the concentrations of lactate and pyruvate were tested in blood. The lactate level of both substances was increased. Sorbitol had the greater effect, and showed its maximum after one hour. For Mannitol the point effect was after four hours. Meanwhile Sorbitol produces an acidosis, the acid-base metabolism is unaffected after Mannitol. The pyruvate-level is not increased significantly, compared with the control group. Therefore the coefficient of lactate to pyruvate is significantly raised. These results highlight the problems of osmotherapy, if the changes of metabolism, induced by the therapy, are not considered. Lactid acidosis, previously existing or a general acidosis, shock, diabetes mellitus and hepatic dysfunctions enhance the risk of osmotherapy especially with Sorbitol.

Acidosis↗
PubMed1980

[Postoperative reactions of blood pressure after neurosurgical operations in deliberate hypotension (author's transl)].

29 patients were operated on cerebral aneurysms and arterio-venous malformations in hypotension induced by sodium nitroprusside, nitroglycerin or a combination of the two substances. The postoperative blood pressure levels were increased to 20--40% compared to the preoperative values. This obvious rebound-effect persisted for several hours. The dangers of postoperative hypertension are demonstrated. The possible pathogenetic factors are discussed.

Adolescent↗
PubMed1977

[Concerfing the E.E.G. changes after the Spiller-Frazer operation for the treatment of trigeminal neuralgia (author's transl)].

A follow-up of 28 patients with trigeminal neuralgia, with E.E.G. examinations was carried out at periods of 6 months to 4 years, after they had been operated on by the Spiller-Frazier method. Acturally in 14 out of the 28, discrete focal changes were observed but they were however, not so marked that one could speak of an actural focus. In comparison with the findings of other authors, the trivial nature of the changes is emphasized and it attributed to the pre-operative preparation, the position of the patients and to particular features of the operative technique.

Adult↗
PubMed1975

Ventral midbrain stimulation, blood pressure responses and their relation to the dopaminergic nigro-striatal pathways.

In 40 cats systematic, electrical stimulation of ventral midbrain structures was performed. In the lightly anaesthetised animals, fixed in a stereotaxic frame, ECoG and arterial blood pressure were registrated. As a result stimulation-induced phasic blood pressure increases have been found within a distinct area including substantia nigra and ventral tegmentum. From the same region nonspecific responses in the ECoG (spindling, recruiting and desynchronisation by low and middle frequent stimulation) could be obtained. The blood pressure responses were enhanced after hemisection at the level of the posterior hypothalamus ipsilateral to the stimulation side. Drugs (Haloperidol, alpha-methyltyrosin and 6-hydroxydopamine), affecting the dopamine metabolism in different ways, abolished the stimulation-induced blood pressure responses. In agreement with previous findings it is concluded that motor and autonomic activation, elicited in ventral midbrain structures are mediated by catecholaminergic transmission.

Animals↗