Biomedical subjects
Publications and source records attributed to A Stepień.
The saturated part of the isoquinoline moiety in the title compound, C17H19NO2, has a twist conformation and the phenyl ring substituent is in an equatorial position. The absolute configuration of the molecule is R and molecules form infinite chains by means of weak hydrogen bonds.
The synthesis and biological activity of new 10-13 membered oxygen-nitrogen heterocyclic systems condensed with two aromatic rings is reported. The structure-activity relationship of these new compounds in X-ray investigation has been studied. Pharmacological investigations have shown that the compounds exhibit weak neuroleptic activity.
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Concentrations of plasma triglycerides, cholesterol, total lipids and lipid peroxides in patients with atherosclerotic lesions of peripheral arteries, who were divided into groups according to the extent and intensity of the lesions, were estimated, as well as lipid peroxide levels in the arterial wall. Statistically highly significant increases of the estimated compounds were found in all groups in comparison with the controls. The existence of a positive correlation between the lipid peroxide concentration and other investigated components in plasma and between the lipid peroxide level in plasma and in the arterial wall was found. Possible mechanisms for lipid peroxide involvement in the process of originating atherosclerotic lesions are discussed.
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The aim of this work was to designate the place of the anus on the perineum with topometric method. The examinations were carried out on 100 healthy male newborns, born in time. Five basic diameters of perineum were determined: anal-symphyseal distance, anal-phallic, anal-scrotal distance, anal-coccygeal distance and transversal dimension of perineum. The material was examined taking into consideration body weight, body length and weight-growth index. Dimensions of perineum most useful to pointing out the location of the anus in case of impotency are: anal-coccygeal distance and anal-scrotal distance. The above dimensions show the greatest relation to male newborns weight.
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Crystals of human oxyhaemoglobin were obtained from poly(ethylene glycol) solutions. Spectroscopic and spectrophotometric measurements on the solutions during crystallization and on the dissolved crystals indicate that the method yields stable crystals of oxyhaemoglobin. Preliminary X-ray studies showed that the crystals obtained are isomorphous with those of deoxyhaemoglobin obtained from poly(ethylene glycol) solutions [Ward, Wishner, Lattman & Love (1975) J. Mol. Biol. 98, 161-177].
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