Biomedical subjects

A Wolpowitz

Publications and source records attributed to A Wolpowitz.

32 records · Page 2Linked to original sources

PubMed1977

Heterotopic cardiac transplantation with a xenograft for assistance of the left heart in cardiogenic shock after cardiopulmonary bypass.

One of the indications for the use of the heterotopic cardiac transplant is temporarily to support a failing heart in the anticipation of its recovery when all other measures of support have been unsuccessful. Human donors are not always available when required and we decided to use a xenograft for this purpose when the need arose. This report details our experience with a baboon and a chimpanzee cardiac xenograft transplant in the heterotopic position. We have found (a) that the operation is technically feasible; (b) that the xenograft will support the failing circulation, but that the more support required, the bigger the xenograft should be and the species chosen accordingly; (c) that severe acute rejection will occur within 4 days and the procedure should therefore only be employed where there is evidence that the patient's own heart function will recover rapidly.

Adult↗

PubMed1977

[The heterotopic heart transplantation: first clinical experiences (author's transl)].

Ten patients, all men, have been operated of heterotopic heart transplantation since the end of 1974. Ages ranged from 59 to 24 years with an average of 38 years. Six of them suffered from ischaemic heart disease, two from cardiomiopathy and two from rheumatic heart disease. All of them presented end stage cardiac disease. The first two patients underwent to left ventricular bypass only, in the remaining eight a right and left bypass was performed. At the present time, June 1977, 6 of the original 10 patients are alive all of them in functional class I. Five of them have resumed a full time job, the sixth will be soon able to do so. Four patients died. There were no deaths from acute rejection, but three died from infection, and the fourth one from a pulmonary embolus, 4 months after transplantation. There has been only one episode of acute rejection which has responded well to the treatment. The advantages of the heterotopic versus the orthotopic cardiac transplantation are discussed.

Adult↗

PubMed1977

The advantage of heterotopic cardiac transplantation over orthotopic cardiac transplantation in the management of severe acute rejection.

The major problems with organ transplantation are rejection of the allograft and the side effects of antirejection therapy. This report describes the successful treatment of a patient in whom rejection of the donor heart developed 10 months after implantation. The recipient's own heart had been left intact and was able to support the circulation during the period of rejection. Indications are that the "rest" period of 10 months was beneficial to the myopathic left ventricle of the recipient's heart.

Adult↗

PubMed1976

Osseous manifestations of congenital syphilis.

The re-emergence of syphilis as a medical problem in most parts of the world makes it necessary to reinstate the congenital osseous manifestations as an important element in the differential diagnosis of the disease in infancy. The previously well-known snuffles, pseudoparalysis and bizarre radiological changes should now be brought to the attention of perhaps more than one generation of physicians who underwent their medical training at the time when the disease was a rarity.

Bone Diseases↗

PubMed1975

Cavitation of pulmonary metastases.

Although cavitation of pulmonary metastases is not as frequent as that of primary involvement, it should always be considered in the differential diagnosis of multiple cavitary lesions. The most frequent cause is squamous cell carcinoma, but it is by no means confined to this type of pathology.

Adult↗

PubMed1975