PubMed Health⌕ Search

Biomedical subjects

A Zezulka

Publications and source records attributed to A Zezulka.

8 recordsLinked to original sources
PubMed1992

Hypertension in aortic valve disease and its response to valve replacement.

We have investigated the prevalence of hypertension and the response of blood pressure to operation in 87 patients with lone aortic valve disease who underwent aortic valve replacement. In patients with aortic stenosis alone 26% were hypertensive pre-operatively (age and sex adjusted blood pressure greater than 160 systolic and or greater than 95 mmHg diastolic) and 24% were hypertensive post-operatively. In those with aortic regurgitation alone, hypertension was present in 65% before and 57% after valve replacement using the same criterion. For combined stenosis and regurgitation, the prevalence was 54% and 62%, respectively. The post-operative increase in systolic pressure in patients with aortic stenosis occurred mainly in those with a history of left ventricular failure. In those with aortic regurgitation or combined stenosis with regurgitation, diastolic pressure rose after valve replacement resulting in a prevalence of diastolic hypertension of 44% and 35%, respectively. Blood pressure changes were not predicted by the type of valve inserted nor its size. Our data show that despite severe symptomatic aortic valve disease, systolic hypertension was common in aortic stenosis and diastolic hypertension was found in aortic regurgitation. This underlines the importance of blood pressure monitoring in patients following aortic valve replacement.

Adult↗
PubMed1988

Clinical evaluation of the Pollenex BP-850 automatic sphygmomanometer.

Eighty subjects were assigned to two conditions in which readings of blood pressure were taken simultaneously by an observer using a Hawkesley Random Zero Sphygmomanometer and by a Pollenex BP-850 Automatic Sphygmomanometer either in its standard form or silenced to stop it bleeping whilst recording blood pressure. Forty subjects were assigned to a comparison group, where simultaneous readings by two observers were taken from one Hawkesley. Analyses performed included correlations, t-tests, and Bland and Altman's (Lancet, 1986, i: 307-310) differences against the mean method. Cues from observer behaviours or the bleeping Pollenex resulted in higher concordance between measures in the standard condition and the Hawkesley comparison condition. However, even in the silent condition the Pollenex proved to be as reliable a monitor of blood pressure as the Hawkesley.

Adult↗
PubMed1986

Human lymphocyte antigens in hypertrophic cardiomyopathy.

An increasing number of genetic studies in hypertrophic cardiomyopathy challenge conventional views on inheritance and suggest genetic heterogeneity or non-genetic disease. We have found changes in relative risk for some antigens with significantly increased frequency of HLA antigen DR4 in this condition. These findings are consistent with there being a genetic component in susceptibility to hypertrophic cardiomyopathy. No evidence was found for HLA linkage using either sib pair analysis or lod scores. This suggests that hypertrophic cardiomyopathy does not have a disease susceptibility gene related to the HLA region on the short arm of chromosome number six. Population HLA associations with hypertrophic cardiomyopathy must thus be explained by other influences of the genetic background on disease susceptibility.

Adult↗
PubMed1985

Longitudinal changes in left ventricular diastolic function in hypertrophic cardiomyopathy.

Digitised M-mode echocardiography was used to study the changes in left ventricular diastolic function over a 3-year period in 11 patients with hypertrophic cardiomyopathy an 14 normals. Compared to normal, in hypertrophic cardiomyopathy, isovolumic relaxation was prolonged (P less than 0.001) and mitral valve opening delayed relative to minimum dimension (P less than 0.001). There was a wide range of values for the peak rates of dimension increase and wall thinning, and although the means were normal, 6 and 8 patients respectively were outside the normal range. There were no significant mean changes in function during the 3.4 +/- 0.3 years of follow-up, but, in 3 patients, marked alterations in relaxation were observed. They showed a gross reduction in the delay in mitral valve opening (125 to 55 125 to 35 and 110 to 75 msec). There was little overall change in isovolumic relaxation in two, but in one patient it reduced from 95 to 50 msec. In most patients with hypertrophic cardiomyopathy, relaxation and diastolic function appear to remain stable over a period of 3 years, and none had an apparent deterioration. Some patients may have an apparently spontaneous "improvement" in function similar in extent to that described due to the therapeutic action of calcium antagonists.

Adult↗
PubMed1984

Standardized methods for comparison of sphygmomanometers.

Medical research in general and equipment comparisons in particular suffer from a deficiency and disparity of statistical analysis. We studied four semi-automatic sphygmomanometers in comparison with the Hawksley random zero mercury manometer. The Astropulse 80 showed marked deviation from the standard machine in average blood pressure recorded and greater variation of readings. The Infrasonde M3010, Bosomat II and Infrasonde D4000 were similar to the standard machine. To help comparability in future studies we suggest the following guidelines; blood pressures to be taken under standard conditions, data to be shown as scatterplots, analysis of variance to be performed and regression analysis to be used only to give an approximate overall view. Finally, we urge the manufacturing companies to conduct such studies and include the results in their brochures.

Blood Pressure Determination↗
PubMed1984

Chronic haemolytic anaemia in hypertrophic cardiomyopathy.

A patient with hypertrophic cardiomyopathy was found to have a chronic intravascular haemolytic anaemia. After investigation this was attributed to the abnormal haemodynamics of the cardiac disease. Treatment with propranolol was associated with an improvement in the anaemia. No further cases of haemolytic anaemia were found in 37 other patients with hypertrophic cardiomyopathy. It is concluded that haemolytic anaemia is a very rare feature of the condition.

Adult↗
PubMed1983

Hypertrophic cardiomyopathy: a common disease with a good prognosis. Five year experience of a district general hospital.

The manifestations and workload in a district general hospital cardiac unit of 39 unselected cases of hypertrophic cardiomyopathy over a five year period are reported. The "typical" form with asymmetrical septal hypertrophy and a gradient was found in only one third of patients, serious ventricular arrhythmias were probably no more common than in the general population, and no deaths occurred during a relatively short follow up (mean 3.1 years). It is concluded that although hypertrophic cardiomyopathy occupies a not insignificant proportion of cardiac workload, unselected cases presenting to a district general hospital represent a relatively mild disease without a grave prognosis.

Adolescent↗