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A Zuckerman

Publications and source records attributed to A Zuckerman.

81 records · Page 5Linked to original sources
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Pathology of lymphoid organs in low-birth-weight human fetuses subjected to antigen-induced influences: a morphological and morphometric study.

To evaluate the pathology of lymphoid organs in low-birth-weight (LBW) human fetuses obtained after premature birth, morphological and morphometric features were studied. The ages of fetuses ranged from 22 to 32 weeks and their weights from 400 to 1180 g. In fetuses at 22-23 weeks without antigenic effects, the lymphoid organs were seen to be well developed and their differentiation was similar to that of full-term fetuses. In older unaffected fetuses (up to 32 weeks), a significant increase in size of the lymphoid organs and a rise in the rate of the differentiation of lymphoid cells were observed. Fetuses exposed to antigen-related diseases underwent morphological changes in lymphoid organs presumably as a consequence of the primary fetal immune reaction. These changes were characterized by a high increase in the number of lymphoblasts and partly of macrophages in the spleen and lymph nodes. Reactive centers in spleen follicles and in lymph nodes, and plasmocytes in all the lymphoid organs, were absent. The main reaction to severe antigenic influences was decompensation of the lymphoid organs manifested morphologically by their devastation as a result of a decrease in the number of small lymphocytes and, in severe cases, of lymphoblasts and macrophages. Exposure of fetuses to antigen-related diseases thus appears to cause marked changes in the normal ontogenesis of lymphoid organs.

Antigens↗
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Faculty practice and university hospital integration.

With a long history as unique providers of health care, academic medical centers have been exempt from many of the troubles plaguing less distinguished health care organizations. But with the increasing dominance of managed care, academic medical centers are facing fierce competition from aggressive and often better organized providers. Burdened with cumbersome and tradition-laden organization structures and volatile turf issues, many academic medical centers are still in the early stages of collaborating with physicians and other providers to develop the care continuums being demanded by payors. Few are operating as truly integrated delivery systems. As the stakes get higher, academic medical centers must accelerate development of health delivery systems by integrating faculty practice ambulatory services with university hospital patient services and those of network partners. Together these services can form the foundation of a system that ultimately provides a complete array of inpatient and outpatient services and is supportive of teaching, research and faculty and staff entrepreneurial activities.

Academic Medical Centers↗
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Revisiting divestiture.

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Decision Making, Organizational↗
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Tumor-promoting and tumor-protective effects of high-fat diets on chemically induced mammary cancer in rats.

We studied the effects of different dietary fats on experimental rat mammary lumorigenesis induced by 9,10-dimethyl-1, 2-benzanthracene (DMBA). Rats were randomly placed into four groups fed different diets: a chow diet, and high-fat (15%) diets derived from avocado, soybean or olive oils. The rats were killed 12 weeks after treatment with DMBA (a single dvse of 10 mg/rat) and maintenance on these diets. The olive diet was associated with a significant reduction in the tumorigenic effect of DMBA: tumor incidence decreased to 30%, as compared to 44%-55% in the other dietary groups studied (p < 0.05). The protective antitumor effect of the olive diet was found to be connected to its dietary content of monounsaturated fatty acids such as oleic and palmitic acids and with serum concentrations of stearic acid. The promotive tumorigenic effects of the other high-fat diets were associated with their high levels of some polyunsaturated fatty acids (linoleic and alinolenic). Malignant mammary tissue exhibited higher values than benign tissue for all the argyrophilic-nucleolar-organizer region parameters measured. The tumor-associated protein p53 was accumulated to high levels in the blood of tumor-bearing rats, but not in that of the non tumor-bearing rats.

9,10-Dimethyl-1,2-benzanthracene↗