Biomedical subjects

Agnieszka P Jurczyk

Publications and source records attributed to Agnieszka P Jurczyk.

9 recordsLinked to original sources

PubMedDate not supplied

[Effect of ethylene glycol on antioxidative enzymes and lipid peroxidation activity in erythrocytes].

Investigations were aimed at demonstrating changes in the activity of enzymes forming an antioxidative barrier and oxidative stress parameters in erythrocytes of rats which were administrated ethylene glycol during 4 weeks. Superoxide dismutase activity (CuZn-SOD) was evaluated by the Misra and Fridovich method, catalase (EC1.11.1.6.) by the Beers and Sizer method and malonyl dialdehyde concentration (MDA) with Placer et all were assessed in the obtained material through the evaluation of TBARS compounds concentration. In the 4th week of the experiment a decrease in catalase (9.3 U/gHb to 5.7 U/gHb) and superoxide dismutase (2378 U/gHb to 1759 U/gHb) activity was observed. Malonyl dialdehyde concentration increased from the initial 0.14 mumol/gHb to 0.24 mumol/gHb. The investigations carried out have demonstrated that long-term intoxication with ethylene glycol leads to a constant generation of free radicals (increase of MDA concentration) and gradual exhaustion of the antioxidative system.

Animals↗

PubMedDate not supplied

[Analysis of selected changes in project the penal code].

In this paper the authors have analysed selected proposals of changes in the project of amendments in the penal code. Special attention has been placed on problem of the legality of the "comma" in art. 156 of the penal code. In this matter also a review of court jurisdiction has been made.

Crime↗

PubMedDate not supplied

[Myocardial infarction as a work accident in Polish Supreme Court decisions. Part I. Excessive stress at work].

This paper deals with Polish Supreme Court opinions on the acceptance of myocardial infarction as work accident. From them the principle emerges that excessive physical or mental work stress can be accepted as the external cause of myocardial infarction in an employee, whereby the excess strain should be judged in each case individually and with reference to the individual situation.

Accidents, Occupational↗

PubMedDate not supplied

[Myocardial infarction as a work accident in Polish Supreme Court decisions. Part II. Job contraindications due to an employee's state of health].

This paper presents the second part on opinions given by the Polish Supreme Court on the acceptance of myocardial infarction as work accident. This it can be seen that, in certain cases, the judgements of the Court are contradictory. For in some cases, an external cause is recognized in the act of permitting employees to work whose state of health would contraindicate the performance of their duties, while in others, the principle is accepted that work duties not considered harmful for healthy people cannot be deemed an external cause for people with health problems. An external cause according to the Supreme Court may also be the act of allowing an employee to work without a valid medical examination, or even by not conducting routine required work-related medical examinations on time.

Accidents, Occupational↗

PubMedDate not supplied

[Selected alcohols on the pro- and anti-oxidative processes in rat erythrocytes].

In forensic medicine practice poisonings are rather frequent, and among them, those caused by fatal "substitution" of ethyl alcohol. One of the most frequently encountered "substitutes" for ethyl alcohol is methanol. The purpose of our research was to determine the concentration of malonic dialdehyde as the expression of lipid peroxidation and antioxidant enzyme activity after dosed chronic ethyl and methyl alcohol intoxication. The experiment was conducted on approx. 6 month-old male inbred Lewis rats each weighing approx. 250 g. Ethanol and methanol solution was given in the concentration 1.0 M. The control group of rats received water. Each experimental group numbered 30 rats, this number was divided into three sub-groups, which were put-down at 4, 8 and 12 weeks. The activity of superoxide dismutase (CuZu-SOD) was determined by the Misra-Fridovich method, catalase (CAT) by the Beers-Sizer method. The concentration of malonic dialdehyde (MDA) was determined using the method of Placer et al. by assessing the concentration of TBARS compounds. Results are expressed as a mean +/- SD. The paired Student's test for small groups were used. Superoxide dismutase SOD1 activity decreased compared with the control group throughout the duration of the experiment from 2212 U/gHb to 1676 U/gHb for ethanol and from 2212 U/gHb to 945 U/gHb for methanol. Catalase activity for methanol decreased from 9.1 U/gHb to 5.1 U/gHb, for ethanol to 7.4 U/gHb. In the 4th week of the experiment increase of malonyl dialdehyde concentration for methanol group was observed--from 0.14 umol/gHb to 0.34 umol/Hb; after 8th weeks it decreased to 0.2 umol/gHb and in the 12th week increased to 0.23 umol/gHb. For ethanol these changes was less visible and reached the level of 0.24 umol/l. The statistical processing of the results was performed on the basis of parametric tests (the t-Student test for small experiments) and computer software Statistica. The statistical significance was set for p<0.05.

Animals↗

PubMedDate not supplied

[Long-term realistically life-threatening disease].

In this paper the authors discuss a legal code description of a wrongly included (as a result of a legislative error) "long-term really life-threatening disease" (dlugotrwala choroba realnie zagrazajaca zyciu) in the Criminal Code. This category of disease impossible to apply in practice since its terms "long-term" and "realistically life-threatening" are mutually exclusive--is nonetheless applicable to crimes committed from Sept. 1, 1998 to Dec. 8, 2003. In effect this causes a change in the qualification of certain acts in Art. 156 of the Criminal Code, to include those in Art. 157, Paragraph 1, and in some cases, even extending to acts named in Art. 157, Paragraph 2 of the Criminal Code.

Criminal Law↗

PubMedDate not supplied

[Changes of the concentration of lipid peroxidation products and thiol groups in rat brains with long-term intoxication with methanol].

The aim of this paper was to define the influence of long-term methanol intoxication on the changes of end products of lipid peroxidation, reacting with thiobarbituric acid (TBA-reactive products) and free SH-group concentration in rat brains. The experiment was conducted on male Lewis rats. The experimental groups received a 1-molar methanol solution and the control group received tap water. The animals were killed after 4, 8 and 12 weeks of intoxication and their brains were collected for further examination, which encompassed measurement of the concentration of TBA-reactive products and free SH-groups. The revealed changes of TBA-reactive products and free SH-group concentration were not statistically significant.

Animals↗

PubMedDate not supplied

[Oxidative stress parameter analysis in rat brains during long-term ethanol intoxication].

The aim of this research was to define the influence of long-term ethanol intoxication on the changes in end products of lipid peroxidation, reacting with thiobarbituric acid (TBA-reactive products) and free SH-groups concentrations in rat brains. The experiment was conducted on male Lewis rats. The experimental groups received a 1-molar ethanol solution and the control group received tap water. The animals were killed after 4, 8 and 12 weeks of intoxication and their brains were collected for further examination, encompassing measurement of the concentration of TBA-reactive products and free SH-groups. A statistically significant increase in the concentration of TBA-reactive products in 4th week of intoxication and decrease in the concentration of free SH-groups in 8th and 12th week of intoxication--compared to the control group--was noticed.

Animals↗

PubMedDate not supplied

[Myocarditis in two cases of HIV infection].

The authors present two cases of death in young persons infected with HIV virus and diagnosed with inflammatory changes of the heart muscle rarely seen in forensic medical practice. In one of the cases, only the findings revealed upon autopsy did prompt the examiner to suspect the infection, even though before death, the patient had been in several hospitals.

AIDS-Related Opportunistic Infections↗