[Oxidative stress parameter analysis in rat brains during long-term ethanol intoxication].

Maciej Barzdo; Ewa Gloc; Agnieszka P Jurczyk; Ewa Meissner; Beata Jankowska; Jarosław Berent; Stefan Szram

PubMed · 16080430

[Oxidative stress parameter analysis in rat brains during long-term ethanol intoxication].

Maciej Barzdo·Ewa Gloc·Agnieszka P Jurczyk·Ewa Meissner·Beata Jankowska·Jarosław Berent·Stefan Szram

Abstract

The aim of this research was to define the influence of long-term ethanol intoxication on the changes in end products of lipid peroxidation, reacting with thiobarbituric acid (TBA-reactive products) and free SH-groups concentrations in rat brains. The experiment was conducted on male Lewis rats. The experimental groups received a 1-molar ethanol solution and the control group received tap water. The animals were killed after 4, 8 and 12 weeks of intoxication and their brains were collected for further examination, encompassing measurement of the concentration of TBA-reactive products and free SH-groups. A statistically significant increase in the concentration of TBA-reactive products in 4th week of intoxication and decrease in the concentration of free SH-groups in 8th and 12th week of intoxication--compared to the control group--was noticed.

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Animals Blood-Brain Barrier Brain Brain Chemistry Dose-Response Relationship, Drug Ethanol Lipid Peroxidation Male Oxidative Stress Random Allocation Rats Rats, Inbred Lew Sulfhydryl Compounds Thiobarbituric Acid Reactive Substances Time Factors English Abstract Journal Article

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Maciej Barzdo, Ewa Gloc, Agnieszka P Jurczyk, Ewa Meissner, Beata Jankowska, Jarosław Berent, Stefan Szram. [Oxidative stress parameter analysis in rat brains during long-term ethanol intoxication].. https://pubmed.ncbi.nlm.nih.gov/16080430/

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