Biomedical subjects

Ake Pilotti

Publications and source records attributed to Ake Pilotti.

2 recordsLinked to original sources

PubMed2006

The impact of microwave-assisted organic synthesis in drug discovery.

Microwave-assisted organic synthesis has revolutionized organic synthesis. Small molecules can be built in a fraction of the time required by classical thermal methods. As a result, this technique has rapidly gained acceptance as a valuable tool for accelerating drug discovery and development processes. This article outlines the basic principles behind microwave technology and summarizes recent trends and areas in drug discovery where this technology has made an impact.

Chemistry, Organic↗

PubMed2003

Efficient large scale microwave assisted Mannich reactions using substituted acetophenones.

A series of substituted acetophenones, paraformaldehyde, and symmetrical dialkylamines were used in microwave enhanced Mannich reactions. Appropriate reaction conditions in terms of choice of solvent, reaction temperature, and reaction time were studied to allow a fast and reproducible production of Mannich bases. Both small (2 mmol) and large scale reactions (40 mmol) were performed successfully, providing a series of substituted Mannich bases in moderate to high yields and high purity.

Acetophenones↗