Efficient large scale microwave assisted Mannich reactions using substituted acetophenones.

Fredrik Lehmann; Ake Pilotti; Kristina Luthman

doi:10.1023/b:modi.0000006809.48284.ed

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Efficient large scale microwave assisted Mannich reactions using substituted acetophenones.

Fredrik Lehmann·Ake Pilotti·Kristina Luthman

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Abstract

A series of substituted acetophenones, paraformaldehyde, and symmetrical dialkylamines were used in microwave enhanced Mannich reactions. Appropriate reaction conditions in terms of choice of solvent, reaction temperature, and reaction time were studied to allow a fast and reproducible production of Mannich bases. Both small (2 mmol) and large scale reactions (40 mmol) were performed successfully, providing a series of substituted Mannich bases in moderate to high yields and high purity.

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Acetophenones Amines Chemistry, Organic Combinatorial Chemistry Techniques Heating Magnetic Resonance Spectroscopy Microwaves Solvents Temperature Time Factors Journal Article Research Support, Non-U.S. Gov't

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Fredrik Lehmann, Ake Pilotti, Kristina Luthman. 2003. Efficient large scale microwave assisted Mannich reactions using substituted acetophenones.. https://doi.org/10.1023/b%3Amodi.0000006809.48284.ed

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